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| 1 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 2 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 3 | Plant Productivity in the Arid and Semiarid Zones显示文摘 | R A Fischer N C Turner | 1978 | Annual Review of Plant Physiology1978，，： | 3 |
| 4 | Environmental and technology policies for climate mitigation 显示文摘 | Fischer C Newell R G | 2008 | Journal of Environmental Economics and Management2008，55，： | 1 |
| 5 | Plant productivity in the arid and semiarid zones显示文摘 | Fischer R A Turner N C | 1978 | Annual Review of Plant Physiology1978，29，： | 1 |
| 6 | Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death inpolyglutamine diseases显示文摘 | de Pril R Fischer D F Roos R A C | 2007 | Mol Cell Neurosci2007，34，： | 1 |
| 7 | Late recurrent saphenofemoral junction reflux after ligation and stripping of the greater saphenous vein显示文摘 | FISCHER R LINDE N DUFF C | 2001 | J Vasc Surg2001，34，2： | 1 |
| 8 | Lattice-re- duction-aided broadcast precoding 显示文摘 | Windapssinger C Fischer R Huber J | 2004 | IEEE Trans- actions on Communications2004，52，12： | 1 |
| 9 | 显示文摘 | Saliger R Fischer U Herta C Fricke J | 1998 | Journal of Non- Crystalline Solids1998，225，： | 1 |
| 10 | Plant production in the arid and semiarid zones 显示文摘 | Fischer R A Turner N C | 1978 | Annual Review of Plant Physiology1978，29，： | 1 |
| 11 | Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE) 显示文摘 | Raaschou-Nielsen 0 Andersen ZJ Beelen R Samoli E Stafoggia M Weinmayr G Hoffmann B Fischer P Nieuwenhuijsen MJ Brunekreef B Xun WW Katsouyanni K Dimakopoulou K Sommar J Forsberg B Modig L Oudin A Oftedal B Schwarze PE Nafstad p De Faire U Pedersen NL Ostenson CG Fratiglioni L Penell J Korek M Pershagen G Eriksen KT Serensen M Tjenneland A Ellermann T Eeftens M Peeters PH Meliefste K Wang M Bueno-de-Mesquita B Key TJ de Hoogh K Concin H Nagel G Yilier A Grioni S Krogh y Tsai MY Ricceri F Sacerdote C Galassi C Migliore E Ranzi A Cesaroni G Badaloni C Forastiere F Tamayo I Amiano P Dorronsoro M Trichopoulou A Bamia C Yineis p Hoek G | 2013 | Lancet Oncol2013，14，9： | 1 |
| 12 | Simultaneous bidirectional message transmission in a chaos-based communication scheme显示文摘 | Vicente R Mirasso C R Fischer I | 2007 | Opt Lett2007，32，40： | 1 |
| 13 | Plant production in the arid and semiarid zones显示文摘 | Turner N C | 1978 | Annu Rev Plant Phys1978，29，： | 1 |
| 14 | Plant production in the arid and semiarid zones显示文摘 | Fischer R A Turner N C | 1978 | Annu Rev Plant Phys1978，29，： | 1 |
| 15 | Plant production in the arid and semiardzones显示文摘 | Fischer R A Turner N C | 1978 | Annu Rev Plant Phys1978，29，： | 1 |
| 16 | A sustainable template for mesoporous zeolite synthesis显示文摘 | White R J Fischer A Goebel C | 2014 | J Am Chem Soc2014，136，7： | 1 |
| 17 | Impact of anti-interleukin-6 re- ceptor blockade on circulating T and B cell subsets in patients with systemic lupus erythematosus 显示文摘 | Shirota Y Yarboro C Fischer R | 2013 | Ann Rheum Dis2013，72，1： | 1 |
| 18 | Plant production in the arid and semiarid zones显示文摘 | Fischer R A Turner N C | 1978 | Annual Review of Plant Physiology1978，29，： | 1 |
| 19 | Plant productivity in the arid and semiarid zones 显示文摘 | Fischer R A Turner N C | 1975 | Annual Review of Plant Physiology1975，29，： | 1 |
| 20 | Plant productivity in the arid and semiarid zones显示文摘 | Fischer R A Turner N C | 1978 | Annal Review of Plant Physiology1978，29，： | 1 |
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