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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Kidney disease outcome quality initiative 显示文摘 | K/DOQI clinical practice guidelines for chronic kidney disease:evaluation classification and stratification | 2002 | Am J Kidney Dis2002，，： | 1 |
| 3 | Updated guidelines for using interferon gamma release assays to detect Mycobacterium turculosis infectiorUnited States, 2010 显示文摘 | Mazurek GH Jereb J Vernon A LoBue P Goldberg S Castro K IGRA Expert Committee Centers for Disease Control and Prevention (CDC) | 2010 | MMWR Recomm Rep2010，59，5： | 1 |
| 4 | Volumetric modulated arc radiotherapy : comparison with intensity- modulated radiotherapy and three- dimensional conformal radiotherapy 显示文摘 | Palma D Vollans E James K therapy for delivery of prostate | 2008 | Int J Radiat Oncol Biol Phys2008，72，： | 1 |
| 5 | Kidney Disease Outcome Quality Initiative显示文摘 | K/DOQI clinical practice guidelines for chronic kidney disease:evaluation classification and stratification | 2002 | Am J Kidney Dis2002，39，2： | 1 |
| 6 | Alternative plate finite of thick plates on elastic foundations 显示文摘 | Ozgan K Daloglu Ayse elements for the analysis T | 2007 | Structural Engineering and Mechanics2007，26，1： | 1 |
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| 9 | Kidney Disease Outcome Quality Initiative 显示文摘 | K / DOQI chronic clinical practice guidelines for kidney disease: evaluation classification and stratification | 2002 | Am J Kidney Dis2002，39，2： | 1 |
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| 12 | Producing gram-negative bacteria by using thiol compounds 显示文摘 | Arakawa Y Shibala N Shibayama K et ah Convenient test for screening metallo-β-lactamase | 2000 | Clin Mierobiol2000，38，1： | 1 |
| 13 | Temporary amniotic membrane treatment of primary pterygium: mechanisms ot recurrence rate 显示文摘 | Ye J Kook patch for the reducing the Ophthalmol KH Yao K | 2006 | Graefes Arch Clin Exp2006，244，5： | 1 |
| 14 | EASL clinical practice guidelines on the management of ascites,spontaneous bacterial peritonitis,and hepatorenal syndrome in cirrhosis显示文摘 | European Association for the Study of the Liver Ginès P Lenz K | 2010 | J Hepatol2010，53，3： | 1 |
| 15 | Effects of losartan and captopril on mortality and mordility in higfh-risk patients after acute my ocardial infarction:the OPTIMAAL randomized trial显示文摘 | Dickstein K Kjekshus J and the OPTIMAAL Steering Committee for the OPTIMAAL Study Group | 2002 | Lancet2002，360，： | 1 |
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| 17 | Genetic variation in PSCA is associated with susceptibility to diffuse- type gastric cancer显示文摘 | Study Group of Millennium Genome project for cancer Sakamoto H Yoshimura K | 2008 | Nat Genet2008，40，6： | 1 |
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| 19 | Evaluation, classification and stratification显示文摘 | National Kidney Foundation: K/DOQI clinical practice guidelines for chronic kidney disease | 2002 | AM J Kidney Dis2002，39，1： | 1 |
| 20 | Kidney Disease Outcome Quality Initiative显示文摘 | K/DOQI clinical practice guidelines for chronic kidney disease:evaluation classification and stratification | 2002 | Am J Kidney Dis2002，39，2： | 1 |
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