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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Mice with a null mutation of the TGF-alpha gene have abnormal skin architecture,wavy hair,and curly whiskers and often develop corneal inflammation显示文摘 | MANN G B FOWLER K J GABRIEL A | 1993 | Cell1993，73，2： | 1 |
| 3 | US for detecting renal calculi with nonenhanced CT as a reference standard 显示文摘 | Fowler K A B Locken J A Duchesne J H | 2002 | Radiology2002，222，1： | 1 |
| 4 | Accumulation of an acidic dehydrin in the vicinity of the plasma membrane during cold acclimation of wheat显示文摘 | Danyluk J Perron A Houde M Limin A Fowler B Benhamou N Sarhan F | 1998 | Plant Cell1998，10，4： | 1 |
| 5 | A third generation water bath based black- body source显示文摘 | FOWLER J B | 1995 | Journal of Research-National Institute of Standards and Technology1995，100，： | 1 |
| 6 | Antagonistic cross-talk between Rac and Cdc42 GTPases regulates generation of reactive oxygen species 显示文摘 | Diebold B A Fowler B Lu J | 2004 | J Biol Chem2004，279，28： | 1 |
| 7 | Effect of carvedilol on survival in severe chromic heart failure显示文摘 | PACKER M COATS A J FOWLER M B | 2001 | N Engl J Med2001，344，： | 1 |
| 8 | An oil-bath-based 293 k to 473 k black- body source显示文摘 | FOWLER J B | 1996 | Journal of Research-National Institute of Standards and Technology1996，101，： | 1 |
| 9 | The effect of carvedilol on morbidity and mortality in severe chronic heart failure显示文摘 | PARCKER M COATS A J S FOWLER M B | 2001 | N Eng J Med2001，344，： | 1 |
| 10 | Barriers to Swift, Even Flow in the Internal Supply Chain of Perioperative Surgical Services De- partment: A Case Study显示文摘 | FREDENDALL L D CRAIG J B FOWLER P J etal | 2009 | Decision Sciences2009，40，2： | 1 |
| 11 | Regulatory role of nitric oxide over hippocampal 5-HT release in vivo 显示文摘 | Pearce B Fowler L Whitton PS | 2001 | Naunyn-Schmiedebergs-Arch-Pharmacol2001，363，3： | 1 |
| 12 | Correlates of amylase and lipase levels in chronic dialysis patients 显示文摘 | Caruana B J Altman R Fowler B | 1998 | Int J Artif Organs1998，11，： | 1 |
| 13 | Effect of carvedilol on survival in severe chronic heart failure 显示文摘 | PACKER M COATS A J FOWLER M B | 2001 | N Engl J Med2001，344，22： | 1 |
| 14 | mixed Caledonian appinite magmas : implication for lamprophyre fractionation and high Ba-Sr granite genesis显示文摘 | Fowler M B Henney P J | 1996 | Contrib Mineral Petrol1996，126，： | 1 |
| 15 | The cytotoxic T lympho cyte response to multiple hepatitis B virus Polymerase epitopes during and after acute viral hepatitis显示文摘 | Rehermann B Fowler P Sidney J | 1995 | J Exp Med1995，181，： | 1 |
| 16 | Compact 810 kA linear transformer driver cavity显示文摘 | Woodworth J R Fowler W E Stoltzfus B S | 2011 | Phys Rev ST Accel Beams2011，14，04： | 1 |
| 17 | The effect of carvedilol on survival in severe chronic heart failure (COPERNICUS)显示文摘 | Parcker M Coats A J S Fowler M B | 2001 | N Engl J Med2001，344，： | 1 |
| 18 | CblE type of homocystinuria due to methionine synthase reductase deficiency: clinical and molecular studies and prenatal diagnosis in two families显示文摘 | Zavadakova P FoWler B Zeman J | 2002 | J Inherit Metab Dis2002，25，6： | 1 |
| 19 | Compact 810 kA linear transformer driver cavity显示文摘 | Woodworth J R Fowler W E Stoltzfus B S | 2011 | Phys Rev Spec Top Accel and Beams2011，14，04： | 1 |
| 20 | Regulatory role of nitricoxide over hippocampal 5 HT release in vivo显示文摘 | SEG1ETH j PEARCE B FOWLER L el al | 2001 | Naunyn SchmiedebergsArch Pharmacol2001，363，3： | 1 |
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