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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression显示文摘 | Victoria G Weis Josane F Sousa Bonnie J LaFleur Ki Taek Nam Jared A Weis Paul E Finke Nadia A Ameen James G Fox James R Goldenring | 2013 | Gut2013，，9： | 3 |
| 3 | Synthesis,characterization and ctalytic applications of a palladlum-nanoparticle-cored dendrlmer显示文摘 | Gopidas K R Whitesell J K Fox M A | 2003 | Nano Lett2003，3，12： | 1 |
| 4 | Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans显示文摘 | Fox D S Cruz M C Sia R A L | 2001 | Molecular Microbiology2001，39，： | 1 |
| 5 | Detection and quantification of intraperitonealfluid using electrical impedance tomography显示文摘 | Sadleir R J Fox R A | 2001 | IEEE Trans BiomedEng2001，48，4： | 1 |
| 6 | A view of cloud computing显示文摘 | ARMBRUST M FOX A GRIFFITH R | 2010 | Communications of the ACM2010，53，4： | 1 |
| 7 | A view of cloud computing显示文摘 | Armbrust M Fox A Griffith R | 2010 | Communications of the ACM2010，53，4： | 1 |
| 8 | Cerebellum and auditory function:an ALE meta-analysis of functional neuroimaging studies显示文摘 | PETACCHI A LAIRD A R FOX P T | 2005 | Hum Brain Mapp2005，25，： | 1 |
| 9 | The values of ternary quadratic forms at prime arguments显示文摘 | Cook R J Fox A | 2001 | Mathematika2001，48，： | 1 |
| 10 | Photoactivation of metal oxide surfaces:photocatalyzed oxidation of alcohols by heteropolytungstates显示文摘 | Fox M A Cardona R Gaillard E | 1987 | J Am Chem Soc1987，109，21： | 1 |
| 11 | Cutting balloon-as sisted angioplasty of an anastomouc carotid-brachial bypass graft stenosis显示文摘 | PRABHUDESAI V ORME R FOX A D | 2004 | Cardiovasc Intervent Radionl2004，27，4： | 1 |
| 12 | When should we rec- ommend catheter ablation for patients with the Wolff- Parkinson-White syndrome? 显示文摘 | Tischenko A Fox DJ Yee R | 2008 | Curr Opin Cardiol2008，23，1： | 1 |
| 13 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 14 | Biocompatible, high precision, wideband, improved Howland current source with lead-lag compensation显示文摘 | TUCKER A S FOX R M SADLEIR R J | 2013 | IEEE Trans Biomed Circuits Syst2013，7，1： | 1 |
| 15 | A view of cloud compu- ting显示文摘 | Armbrust M Fox A Gfit~th R | 2009 | Communications of the ACM2009，53，4： | 1 |
| 16 | Principal mechanisms of damping in cast iron 显示文摘 | Adams R D Fox M A O | 1973 | Journal of the Iron and Steel Institute1973，，7： | 1 |
| 17 | G protein - coupled receptors in Anopheles gambiae显示文摘 | HILL C A FOX A N PlqqS R J | 2002 | Science2002，298，5591： | 1 |
| 18 | Effects of aspirin dose when used alone or in combination with clopidogrel inpatients with acute coronary syndromes:observations from the Clopidogrel in Unstable angina to prevent Recurrent Events(CURE)study显示文摘 | Peters R J Mehta S R Fox K A | 2003 | Circulation2003，108，14： | 1 |
| 19 | The role of soil surface crusting in desertification and strategies to reduce crusting显示文摘 | Fox D M Bryan R B Price A G | 2004 | Environmental Monitoring and Assessment2004，99，13： | 1 |
| 20 | The venous pump of the human for preliminary report 显示文摘 | Cardner A M Fox R H | 1983 | Bristol Medico Med Chir1983，，98： | 1 |
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