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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 3 | Nuclear locali- zation of Myomesin-l: Possible functions显示文摘 | Reddy K B Fox J E Priee M G | 2008 | Muscle Res Cell Motil2008，29，1： | 1 |
| 4 | Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events(TRA 2°P)-TIMI 50 trial 显示文摘 | MORROW D A SCIRICA B M FOX K A | 2009 | Am Heart J2009，158，3： | 1 |
| 5 | Synthesis of New Indeno iso- quinolines: Cytotoxic Non-Camptothecin Topoi- somerase I Inhibitors 显示文摘 | JAYARAMAN M FOX B M HOLLINGSHEAD M etal | 2010 | J Med Chem2010，43，4： | 1 |
| 6 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 7 | The role of soil surface crusting in desertification and strategies to reduce crusting显示文摘 | Fox D M Bryan R B Price A G | 2004 | Environmental Monitoring and Assessment2004，99，13： | 1 |
| 8 | Abyssal anti-dunes显示文摘 | Fox P J Heezen B C Harian A M | 1968 | Nature1968，220，： | 1 |
| 9 | The relationship of soil loss by interrill erosion to slope gradient显示文摘 | Fox D M Bryan R B | 1999 | Catena1999，38，3： | 1 |
| 10 | Glucosamine hydrochloride for the treat- ment of osteoarthritis symptoms 显示文摘 | Fox B A Stephens M M | 2007 | Clin Interv Aging2007，2，4： | 1 |
| 11 | Quantification and localization of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection显示文摘 | Ward S M Fox B C Brown P J | 2007 | J Heptol2007，47，： | 1 |
| 12 | The influence of slope angle on final infiltration rate for interrill conditions显示文摘 | Fox D M Bryan R B Price A G | 1997 | Geoderma1997，80，12： | 1 |
| 13 | Recent advances into the understanding of mesenchymal stem cell trafficking显示文摘 | FOX J M CHAMBERLAIN G ASHTON B A | 2007 | Br J Haematol2007，137，： | 1 |
| 14 | Medication, aller-gy, and adverse drug event discrepancies in ambulatorycare显示文摘 | Stephens M Fox B Kukulka G | 2008 | iraw2008，40，2： | 1 |
| 15 | Microbiology and biochemistry of fossa (pit) cheese 显示文摘 | GOBBETTI M FOLKERTSMA B FOX P F | 1999 | Int Dairy J1999，9，： | 1 |
| 16 | Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study 显示文摘 | MEIGS J B LARSON M G FOX C S | 2007 | Diabetes Care2007，30，10： | 1 |
| 17 | Diamond devices and electrical properties 显示文摘 | Fox B A Hartsell M L | 1995 | Diamond Related Mater1995，4，56： | 1 |
| 18 | Investigation of high temperature blackbody BB3200显示文摘 | Metzdorf J Harrison N J Fox N P Khlevnoy B B Khromtchenko V B Mekhontsev S N Shapoval V I Zelener M F Sapritsky V I | 1998 | Metrologia1998，35，： | 1 |
| 19 | The natural history and management of symptomatic and asymptomatic vertebral hemangiomas显示文摘 | Fox M W Onofrio B M | 1993 | J Neurosurg1993，78，1： | 1 |
| 20 | The influence of slope an- gle on final infiltration rate for interrill conditions 显示文摘 | Fox D M Bryan R B Price A G | 1997 | Geoderma1997，80，12： | 1 |
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