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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 3 | Coating characteristics and tribological properties of sputterdeposited MoS2/metal composite coatings deposited by closed field unbalanced magnetron sputter ion plating显示文摘 | Renevier N M Fox V C Teer D G | 2000 | Surface and Coatings Technology2000，127，： | 2 |
| 4 | Efficacy of me-mantine on behavioral and psychological symptoms related to dementia:a systematic meta-analysis显示文摘 | MAIDMENT I D FOX C G BOUSTANI M | 2008 | Ann Pharmacother2008，42，1： | 1 |
| 5 | Mice lacking inducible nitric oxide synthase develop spontaneous hypercholestemlaemia and aortic atheromas显示文摘 | Ihrig M Dangler C A Fox J G | 2001 | Atherosclerosis2001，156，1： | 1 |
| 6 | High-salt diet induces Helicobacter pylori colonization in epithelial hyperplasia and parietal cell loss, and enhances helicobacter pylori colonization in C57BL/6 mice显示文摘 | Fox J G Dangler C A Taylor N S | 1999 | Cancer Res1999，59，9： | 1 |
| 7 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 8 | Phylogenetic structure of the prokaryotic domain,the primary kingdoms显示文摘 | Woese C R and Fox G E | 1977 | Proceeding of the National Academy of Science USA1977，74，11： | 1 |
| 9 | Red-pigmented micrococci:a basis for taxonomy显示文摘 | Brooks B W Murray R G Johnson J L Stackebrandt E Woese C R Fox G E | | 0，，： | 1 |
| 10 | Application of the Cornell net carbohydrate and protein model for cattle consuming forage 显示文摘 | Fox D G Barry M C Pitt R E | 1995 | Journal of Animal Science1995，73，： | 1 |
| 11 | Molecular pathogenesis of iron overload 显示文摘 | TRINDER D FOX C VAUTIER G | 2002 | Gut2002，51，： | 1 |
| 12 | Prediction of ruminal volatile fatty acids and pH within thd net carbohydrate and protein system显示文摘 | Pitt R E Van Kessel J S Fox D G Pell A N Barry M C Van Soest P J | 1996 | Journal of Animal Science1996，74，： | 1 |
| 13 | Brazing of ceramics显示文摘 | Fox C W Slaughter G M | 1964 | Welding Journal1964，43，7： | 1 |
| 14 | Inflammation, atrophy, and gastric cancer 显示文摘 | Fox J G Wang T C | 2007 | J Clin Invest2007，117，1： | 1 |
| 15 | Quantification of reg- ulatory T ceils enables the identification of high-risk breast cancer patients and those at risk of late relapse 显示文摘 | Bates G J Fox S B Han C | 2006 | J Clin Oncol2006，24，34： | 1 |
| 16 | Conservation of Primary Structure in 16S Ribosomal RNA显示文摘 | WOESE C R FOX G E ZABLEN L | 1975 | Nature1975，254，： | 1 |
| 17 | Adjusting nutrient requirements of beef cattle for animal and environmental variations显示文摘 | FOX D G SNIFFEN C J O'CONNOR J D | 1988 | J Anim Sci1988，66，： | 1 |
| 18 | Coating characteristics and tribological properties of sputter-deposited MoSJmetal composite coatings deposited by closed field unbalanced mag- netron sputter ion plating 显示文摘 | Renevier N M Fox V C Teer D G | 2000 | Surface and Coatings Technolo- gy2000，127，： | 1 |
| 19 | The structure of Tfibological improved MoS2-metal composite coatings and their industrial applications 显示文摘 | Fox V C Renevier N Teer D G | 1999 | Surface and Coatings Technology1999，，： | 1 |
| 20 | A prospective evaluation of lipoprotein associated-phospholipaseA(2) levels and the risk of future cardiovascular events in women显示文摘 | Blake G J Dada N Fox J C | | 0，，05： | 1 |
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