|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study显示文摘AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with LAM.METHODS This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were analysed.RESULTS Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001).CONCLUSION TDF monotherapy proved to be safe and not inferior to the LAM+ADV combination therapy in maintaining virologic response in patients with CHB and previous LAM failure. In addition, the use of TDF generated a significant savings in hospital costs. | Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 | 2017 | World Journal of Gastroenterology2017，23，41： | 16 |
| 3 | Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: Is there still a role for these drugs?显示文摘四乙秋兰姆化二硫和钙 carbimide 是二白酒威慑然而,广泛地在那里在酒精中毒治疗使用的狂言存在对他们的安全的大担心。hepatotoxicity 上的报告主要与四乙秋兰姆化二硫治疗有关,被出版了。钙 carbimide 的肝毒素的潜力是很好描绘的更少。这里,我们描述与被提交到 hepatotoxicity 的一张注册表并且当规定这些混合物时,指出我们面对的限制的这个治疗学的组有关的肝损坏的四个案例。对在白酒依赖的管理的这些混合物的角色的重估清楚地被需要。 | Carmen Verge M Isabel Lucena Enrique López-Torres M José Puche-García Enrique Fraga Manuel Romero-Gomez Raúl J Andrade | 2006 | World Journal of Gastroenterology2006，12，31： | 2 |
| 4 | Evaluation of different media in the reprodution of Paecilomyces lilacinus显示文摘 | LOPEZ M Z AYAS M A FRAGA M | 1992 | Revista de Protection Vegetal1992，7，： | 1 |
| 5 | Kinetic and thermodynamic studies of an epoxy system diglycidyl ether of bisphenol K/1, 2 diamine cyelohexane/calcium carbonate filler显示文摘 | Nunez L Fraga F Castro A | 2000 | Journal of Applied Polymer Science2000，75，： | 1 |
| 6 | Crystal structure of orthosphenic acid显示文摘 | GONZLEZ A FRAGA B M GONZALEA P | 1983 | J Org Chem1983，48，： | 1 |
| 7 | Fracture resistance of endodontically treated teeth restored with glass fiber posts of different lengths显示文摘 | Franco I B Lins do Valle A Pomp6ia Fraga de Almeida A L | 2014 | The Journal of prosthetic dentistry2014，111，1： | 1 |
| 8 | Primary extramedullary myeloid tumor of the breast:a case report and review of the literature显示文摘 | Quintas Cardama A Fraga M A ntunez J | 2003 | Ann Hemato l2003，82，7： | 1 |
| 9 | Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer显示文摘 | Fraga MF Ballestar E Villar-Garea A | 2005 | Nat Genet2005，37，4： | 1 |
| 10 | Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis显示文摘 | CRUZ A FRAGA A G FOUNTAIN J J | | 0，，8： | 1 |
| 11 | Synthesis and pharmacological evaluation of novel heterotricyclic aeylhydrazone derivatives, designed as PAF antagonists显示文摘 | FRAGA A G M RODRIGUES C R MIRANDA A L P | 2000 | European Journal of Pharmaceutical Sciences2000，11，： | 1 |
| 12 | The ADAMTS12 metal- loprotease gene is epigenetically silenced in tumor cells and transcrip- tionally activated in the stroma during progression of colon cancer 显示文摘 | Moneada-Pazos A Obaya A J Fraga ME | 2009 | J Cell Sei2009，122，16： | 1 |
| 13 | Smoking and low antioxidant levels increase oxidative damage to sperm DNA 显示文摘 | Fraga CG Motchnik PA Wyrobek A J | 1996 | Mutat Res1996，351，2： | 1 |
| 14 | Bronchoscope and tracheotomy removal of bronchial foreign body显示文摘 | Fraga J C Neto A M Seitz E | 2002 | J Pediatr Surg2002，37，8： | 1 |
| 15 | Loss of acetylation at Lysl6 and trimethylation at Lys 20 of histone H4 is a common hallmark of human cancer 显示文摘 | Fraga MF Ballestar E Villar-Garea A | 2005 | Nat Genet2005，37，4： | 1 |
| 16 | TIT cure diagram for an epoxy system diglycidyl ether of bisphenol A/1,2diamine cyclphexane/cal- cium carbonate filler 显示文摘 | Nunez L Fraga F Castro A | 2001 | Polymer2001，42，8： | 1 |
| 17 | Effects of continuous light exposure on antioxidant enzymes, porphyric enzymes and cellular damage in the Harderian gland of the Syrian hamster显示文摘 | Tomas Zapico C Coto Montes A Martinez Fraga J | 2003 | J Pineal Res2003，34，1： | 1 |
| 18 | Quercetin prevents oxidative stress and NF-κB activation in gastric mucosa of portal hypertensive rats显示文摘 | Andrea J. Moreira Christina Fraga María Alonso Pilar S. Collado Claudio Zetller Claudio Marroni Norma Marroni Javier González-Gallego | 2004 | Biochemical Pharmacology2004，，10： | 1 |
| 19 | Loss of acetylation at Lys16and trimethylation at Lys20of histone H4is a common hallmark of human cancer显示文摘 | Fraga MF Ballestar E Villar-Garea A | 2005 | Nat Genet2005，37，4： | 1 |
| 20 | Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer显示文摘 | Fraga MF Ballestar E Villar-Garea A | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员