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| 1 | Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: Is there still a role for these drugs?显示文摘四乙秋兰姆化二硫和钙 carbimide 是二白酒威慑然而,广泛地在那里在酒精中毒治疗使用的狂言存在对他们的安全的大担心。hepatotoxicity 上的报告主要与四乙秋兰姆化二硫治疗有关,被出版了。钙 carbimide 的肝毒素的潜力是很好描绘的更少。这里,我们描述与被提交到 hepatotoxicity 的一张注册表并且当规定这些混合物时,指出我们面对的限制的这个治疗学的组有关的肝损坏的四个案例。对在白酒依赖的管理的这些混合物的角色的重估清楚地被需要。 | Carmen Verge M Isabel Lucena Enrique López-Torres M José Puche-García Enrique Fraga Manuel Romero-Gomez Raúl J Andrade | 2006 | World Journal of Gastroenterology2006，12，31： | 2 |
| 2 | Estimation of visceral fat is useful for the diagnosis of significant fibrosis in patients with non-alcoholic fatty liver disease显示文摘BACKGROUND Obesity is a risk factor for non-alcoholic fatty liver disease(NAFLD),although obese patients with NAFLD do not always develop significant fibrosis.The distribution of body fat could predict the risk of NAFLD progression.AIM To investigate the role of bioelectrical impedance-estimated visceral fat(VF)in assessing NAFLD severity.METHODS In this cross-sectional study,patients with biopsy-proven NAFLD were prospectively included.All patients underwent anthropometric evaluation,blood tests and bioelectrical impedance analysis.RESULTS Between 2017 and 2020,119 patients were included[66.4%male,56 years(SD 10.7),62.2%obese,61.3%with metabolic syndrome].Sixty of them(50.4%)showed significant fibrosis(≥F2)in liver biopsy.Age,VF and metabolic syndrome were associated with significant fibrosis(61 years vs 52 years,16.4 vs 13.1,73.3%vs 49.2%,respectively;P<0.001 for all).In the multivariate analysis,VF and age were independently associated with significant fibrosis(VF,OR:1.11,95%CI:1.02-1.22,P=0.02;age,OR:1.08,95%CI:1.03-1.12,P<0.01).A model including these variables showed and area under the receiver operating characteristic curve(AUROC)of 0.75,which was not inferior to transient elastography or NAFLD fibrosis score AUROCs.We developed a nomogram including age and VF for assessing significant fibrosis in routine practice.CONCLUSION VF is a surrogate marker of liver fibrosis in patients with NAFLD.Bioelectrical impedance analysis is an inexpensive and simple method that can be combined with age to guide patient referral when other resources may be unavailable. | Marta Hernández-Conde Elba Llop Carlos Fernández Carrillo Beatriz Tormo Javier Abad Luis Rodriguez Christie Perelló Marta López Gomez JoséLuis Martínez-Porras Natalia Fernández Puga Maria Trapero-Marugan Enrique Fraga Carlos Ferre Aracil JoséLuis Calleja Panero | 2020 | World Journal of Gastroenterology2020，26，42： | 2 |
| 3 | Kinetic and thermodynamic studies of an epoxy system diglycidyl ether of bisphenol K/1, 2 diamine cyelohexane/calcium carbonate filler显示文摘 | Nunez L Fraga F Castro A | 2000 | Journal of Applied Polymer Science2000，75，： | 1 |
| 4 | Biotransformation of the diterpenes epicandicandiol and candicandiol by Mucor plumbeus 显示文摘 | Fraga B M Alvarez L Su6rez S | 2003 | J Nat Prod2003，66，3： | 1 |
| 5 | Behavioral changes andmitochondrial dysfunction in a rat model of schizophrenia induced byketamine 显示文摘 | de Oliveira L Fraga DB De Luca RD | 2011 | Metab Brain Dis2011，26，1： | 1 |
| 6 | Fracture resistance of endodontically treated teeth restored with glass fiber posts of different lengths显示文摘 | Franco I B Lins do Valle A Pomp6ia Fraga de Almeida A L | 2014 | The Journal of prosthetic dentistry2014，111，1： | 1 |
| 7 | High-performance capillary electrophoretic method for the quantification of 5-methyl 2′-deoxycytidine in genomic DNA:Application to plant,animal and human cancer tissues显示文摘 | Fraga M F Uriol E Borja Diego L | 2002 | Electrophoresis2002，23，11： | 1 |
| 8 | Synthesis and pharmacological evaluation of novel heterotricyclic aeylhydrazone derivatives, designed as PAF antagonists显示文摘 | FRAGA A G M RODRIGUES C R MIRANDA A L P | 2000 | European Journal of Pharmaceutical Sciences2000，11，： | 1 |
| 9 | Humics as an electron donor for anaerobic respiration显示文摘 | Lovley D R Fraga J L Coates J D | 1999 | Environ Microbiol1999，1，1： | 1 |
| 10 | Inhibition of angiotensin converting enzyme activity by flavanol-rich foods 显示文摘 | Actis-Goretta L Ottaviani J Fraga C | 2006 | Journal of Agricultural and- Food Chemistry2006，54，： | 1 |
| 11 | TIT cure diagram for an epoxy system diglycidyl ether of bisphenol A/1,2diamine cyclphexane/cal- cium carbonate filler 显示文摘 | Nunez L Fraga F Castro A | 2001 | Polymer2001，42，8： | 1 |
| 12 | Elevation of plasmatic endothelin in patients with heart failure 显示文摘 | Galindo - Fraga A Arfieta O Castillo - Martinez L | 2003 | Arch Med Res2003，34，5： | 1 |
| 13 | Inhibition of angiotensin converting enzyme activity by flavanol-rich foods 显示文摘 | Actis-Goretta L Ottaviani JI Fraga CG | 2006 | Journal of agricultural and Food Chemistry2006，54，1： | 1 |
| 14 | Inhibition of anglotensin converting enzyme activity by flavanol-rich foods 显示文摘 | Actis-Goretta L Ottavlanl J I Fraga C G | 2006 | Journal of Agricultural and Food Chemistry2006，54，： | 1 |
| 15 | TTT cure diagram for an epoxy system diglycidyl ether of bisphenol A/l, 2 diamine cyclohexane/calcium carbonate filler显示文摘 | NUNEZ L FRAGA F CASTRO A | 2001 | Polymer2001，42，8： | 1 |
| 16 | T-cell/histiocyte-rich large B-cell lymphoma is a disseminated aggressive neoplasm:differential diagnosis from Hodgkin's lymphoma显示文摘 | Fraga M Sanchez-Verde L Forteza J | 2002 | Histopathology2002，41，3： | 1 |
| 17 | Zinc deficiency causes oxidative damage to proteins, lipids and DNA in rat testes显示文摘 | Oteiza P l Olin K L Fraga C G Keen CL | 1995 | Journal of Nutrition1995，，125： | 1 |
| 18 | Behavioral changes and mitochondrial dysfunction in a rat model of schizophrenia induced by ketamine显示文摘 | de Oliveira L Fraga DB De Luca RD | 2011 | Metab Brain Dis2011，26，： | 1 |
| 19 | Biotransformation of the diterpenes epicandicandiol and candicandiol by Mucor plumbeus显示文摘 | Fraga B M Alvarez L Suárez S | 2003 | J Nat Prod2003，66，： | 1 |
| 20 | Droplets in the cold and dense linear sigma model with quarks显示文摘 | PALHARES L F FRAGA E S | 2010 | Phys Rev D2010，，： | 1 |
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