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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | China Patient-centered Evaluative Assessment of Cardiac Events Prospective Study of Acute Myocardial Infarction: Study Design显示文摘 | Rachel P Dreyer Xi Li Xue Du Nicholas S Downing Li Li Hai-Bo Zhang Fang Feng Wen-Chi Guan Xiao Xu Shu-Xia Li Zhen-Qiu Lin Frederick A Masoudi John A Spertus Harlan M Krumholz Li-Xin Jiang | 2016 | Chinese Medical Journal2016，，1： | 13 |
| 3 | Bilateral vs unilateral placement of metal stents for inoperable highgrade hilar biliary strictures: A systemic review and meta-analysis显示文摘BACKGROUND Bilateral vs unilateral biliary stenting is used for palliation in malignant biliary obstruction.No clear data is available to compare the efficacy and safety of bilateral biliary stenting over unilateral stenting.AIM To assess the efficacy and safety of bilateral vs unilateral biliary drainage in inoperable malignant hilar obstruction.METHODS PubMed,Embase,Scopus,and Cochrane databases,as well as secondary sources(bibliographic review of selected articles and major GI proceedings),were searched through January 2019.The primary outcome was the re-intervention rate.Secondary outcomes were a technical success,early and late complications,and stent malfunction rate.Pooled odds ratio(OR)and 95%confidence interval(CI)were calculated for each outcome.RESULTS A total of 9 studies were included(2 prospective Randomized Controlled Study,5 retrospective studies,and 2 abstracts),involving 782 patients with malignant hilar obstruction.Bilateral stenting had significantly lower re-intervention rate compared with unilateral drainage(OR=0.59,95%CI:0.40-0.87,P=0.009).There was no difference in the technical success rate(OR=0.7,CI:0.42-1.17,P=0.17),early complication rate(OR=1.56,CI:0.31-7.75,P=0.59),late complication rate(OR=0.91,CI:0.58-1.41,P=0.56)and stent malfunction(OR=0.69,CI:0.42-1.12,P=0.14)between bilateral and unilateral stenting for malignant hilar biliary strictures.CONCLUSION Bilateral biliary drainage had a lower re-intervention rate as compared to unilateral drainage for high grade inoperable malignant biliary strictures,with no significant difference in technical success,and early or late complication rates. | Munish Ashat Sumant Arora Jagpal S Klair Christopher A Childs Arvind R Murali Frederick C Johlin | 2019 | World Journal of Gastroenterology2019，25，34： | 5 |
| 4 | Update on Cardiovascular Implantable Electronic Device Infections and Their Management: A Scientific Statement From the American Heart Association显示文摘 | Larry M. Baddour Andrew E. Epstein Christopher C. Erickson Bradley P. Knight Matthew E. Levison Peter B. Lockhart Frederick A. Masoudi Eric J. Okum Walter R. Wilson Lee B. Beerman Ann F. Bolger N A. Mark Estes Michael Gewitz Jane W. Newburger Eleanor B. S | 2010 | Circulation2010，，3： | 4 |
| 5 | Quantitative aspects of reversible osmotic opening of the blood-brain barrier显示文摘 | Rapoport S I Fredericks W R Ohno K | 1980 | Am J Physiol1980，238，5： | 2 |
| 6 | Cough-associated headache in patients with Chiari I malformation: CSF flow analysis by means of cine phase-contrast MR imaging显示文摘 | Bhadelia RA Frederick E Patz S | 2011 | AJNR Am J Neuroradiol2011，32，4： | 1 |
| 7 | Body image as a leisure con straint :Examining the experience of aerobic exercise classes for young women显示文摘 | FREDERICK C SHAW S M | 1995 | leisure Sci1995，17，2： | 1 |
| 8 | Detection of PR vi- ral DNA in tonsillar cells of latently infected pigs 显示文摘 | Talmage T B Kwang O S Frederick J F | 1995 | Am J Vet Res1995，56，5： | 1 |
| 9 | Components of plastic: experimental studies in animals and relevance for human health显示文摘 | Talsness Chris E. Andrade Anderson J. M. Kuriyama Sergio N. Taylor Julia A. vom Saal Frederick S | 2009 | Philosophical Transactions of the Royal Society B2009，，1526： | 1 |
| 10 | Safety and immunogenicity of a baculovims-expressed hemagglutinin influenza vaccine: a randomized controlled trial显示文摘 | John J T Gillbert M S Frederick G H | 2007 | JAMA2007，297，14： | 1 |
| 11 | Tacrolimus pharmacogenetics: the CYP3A5*1 allele predicts low dose-normalized tacrolimus blood concentrations in whites and South Asians显示文摘 | MACPHEE IA FREDERICKS S MOHAMED M | 2005 | Transplantation2005，79，： | 1 |
| 12 | 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-- Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percu- taneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update) : A Report of the American College of Cardi- ology Foundation/American Heart Association Task Force on Prac- tice Guidelines显示文摘 | Frederick G K Mary H Sidney C S | 2009 | JACC2009，54，23： | 1 |
| 13 | Pregnancy-associated plasma protein-A(PAPP-A)and cardiovascularrisk显示文摘 | Consuegra-Sanchez L Fredericks S Kaski JC | 2009 | Atherosclerosis2009，203，2： | 1 |
| 14 | Remotely atte- nded home monitoring of sleep disorders 显示文摘 | Kayyali HA Weimer S Frederick C | 2008 | Telemed e-Health2008，14，4： | 1 |
| 15 | Full scale self-propulsion computations using discretized propeller for the kriso eontainer ship KCS 显示文摘 | ALEJANDRO M C PABLO M C FREDERICK S | 2011 | Computers & Fluids2011，51，： | 1 |
| 16 | Pollen-mediated gene flow in California cotton depends on pollinator activity显示文摘 | ALLEN E V D Frederick J S Kent J B | 2005 | Crop Science2005，45，4： | 1 |
| 17 | The effects of global climate change on seagrasses 显示文摘 | Frederick T S Hilary A N | 1999 | Aquatic Botany1999，63，： | 1 |
| 18 | Acoustic emis- sion based tension characteristics of sandwich compos- ites显示文摘 | Amilcar Q Basir S Frederick J | 2004 | Composites Part B: Engineering2004，355，1： | 1 |
| 19 | A computerized method of visual acuity testing显示文摘 | Roy W Beck Pamela S Moke Andrew H Turpin Frederick L Ferris John Paul SanGiovanni Chris A Johnson Eileen E Birch Danielle L Chandler Terry A Cox R.Clifford Blair Raymond T Kraker | 2003 | American Journal of Ophthalmology2003，，2： | 1 |
| 20 | Elaborating a Simpler theory of anchoring显示文摘 | Frederick S Kahneman D Mochon D | | 0，，01： | 1 |
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