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| 1 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 2 | Blockade of irradiation-induced autophagosome forma-tion impairs proliferation but does not enhance cell deathin HCT-116 human colorectal carcinoma cells显示文摘 | de Albuquerque-Xavier AC Bastos LG de Freitas JC Jr etal | 2012 | Int J On-col2012，40，4： | 1 |
| 3 | Decrease of the occurrence of pneumothorax in newborns with respiratory distress syndrome through reduction of ventilatory parameters显示文摘 | Brunherotti MA Freitas Vianna JR Silveira CS | 2003 | J pediatr2003，79，1： | 1 |
| 4 | Straight and angulated abutments in platform switching:influence of loading on bone stress by three-dimensional finite element analysis显示文摘 | Martini AP Freitas AC Jr Rocha EP | | 0，，02： | 1 |
| 5 | Finite element stress analysis of edentulous mandibles with different bone types supporting multiple-implant super-structures显示文摘 | de Almeida EO Rocha EP Freitas AC JR | 2010 | Int J Oral Maxil- lofac Implants2010，25，6： | 1 |
| 6 | Nanodentistry显示文摘 | Freitas Jr RA | 2000 | Am Dent Assoc2000，131，11： | 1 |
| 7 | The effect of imme- diate dentin sealing on the marginal adaptation and bond strengths of total-etch and self-etch adhesives 显示文摘 | Duarte SJ de Freitas CR Saad JR | 2009 | J Prosthet Dent2009，102，1： | 1 |
| 8 | The effect of implant design on insertion torque and immediate micromotion显示文摘 | Freitas AC Jr Bonfante EA Giro G | 2012 | Clin Oral Implants Res2012，23，1： | 1 |
| 9 | Cyclooxygenase -2 expres- sion in endometrial polyps during menopause 显示文摘 | Maia H Jr Correia T Freitas LA | 2005 | Gynecol Endocrinol2005，21，6： | 1 |
| 10 | A Boost PWM soft-single-switched Converter with Low Voltage and Current Stresses 显示文摘 | Lambert J A Vieira J B Jr Carlos de Freitas L | 1998 | IEEE trans on Power Electronics1998，13，1： | 1 |
| 11 | Exploratory design in medical nanotechnology: a mechanical artificial red cell 显示文摘 | Freitas RA Jr | 1998 | Artif Cell Blood Substit Immobil Biotechnol1998，26，4： | 1 |
| 12 | Hybrid transceiver schemes for spatial multiplexing and diversity in MIMO systems 显示文摘 | Freitas Jr W C Cavalcanti F R P Lopes R R | 2005 | Journal Of Communication and Information Systems2005，20，3： | 1 |
| 13 | Tridimensional analysis of maxillary sinus anatomy related to sinus lift procedure显示文摘 | Velloso GR Vidigal GM Jr de Freitas MM | 2006 | Implant Dent2006，15，2： | 1 |
| 14 | Masticato-ry efficiency in class II and class III dentofacial deformities显示文摘 | Picinato-Pirola MN Mestriner W Jr Freitas 0 | 2012 | Int J Oral Maxillofac Surg2012，41，7： | 1 |
| 15 | Ultrasound energy and endothelim cell loss with stop-and-chop and nuclear preslice phacoemulsi- fication 显示文摘 | Pereim A C Porfirio F Jr Freitas L L | 2007 | Cataract Refract Surg2007，32，4： | 1 |
| 16 | Finite element stress analysis of edentulous mandible with different bone types supporting multiple-implant superstructures 显示文摘 | de-Almeida E O Rocha P R Freitas A C Jr | 2010 | Int J Oral Maxillofac Implants2010，25，6： | 1 |
| 17 | Avian anticoccidial activity of a novel membrane-interactive peptide selected from phage display libraries显示文摘 | da Silva A Jr Kawazoe U Freitas FF | 2002 | Mol Biochem parasitol2002，120，1： | 1 |
| 18 | A survey of hierarchical classifica- tion across different application domains显示文摘 | Silla Jr C N Freitas A A | 2011 | Data Mining and Knowledge Discovery2011，22，12： | 1 |
| 19 | Lead in saliva from lead-exposed and unexposed children 显示文摘 | Costa de Almeida GR Umbelino de Freitas C Barbosa F Jr etal | 2009 | Sci Total Environ2009，407，5： | 1 |
| 20 | Mechanical behavior of ceramic veneer in zirconia-based restorations: a 3- dimensional finite element analysis using microeomputed tornography data 显示文摘 | Rocha EP Anehieta RB Freitas AC Jr | 2011 | J Prosthet Dent2011，105，1： | 1 |
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