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| 1 | BCL2 inhibits cell adhesion, spreading, and motility by enhancing actin polymerization显示文摘BCL2 最好作为多功能的 anti-apoptotic 蛋白质被知道。然而,很少在房间粘合剂和活动性事件对它的角色被知道。这里,我们证明 BCL2 可以在房间粘附的规定起一个作用,传播,并且活动性。BCL2 什么时候是在有教养的鼠科、人的房间线,传播的房间,粘附,和活动性的 overexpressed,被损害。与这些结果一致, Bcl2 的损失导致了在 Bcl2 空的老鼠观察的更高的活动性与野类型相比的胚胎的成纤维细胞(MEF ) 房间。房间粘附和活动性的 BCL2 规定的机制可以包含包含 BCL2,肌动朊,和 gelsolin 的建筑群的形成,它看起来机能上地减少 gelsolin 的切断的活动。我们观察到从 overexpressed BCL2 提高了的 MCF-7 和 NIH3T3 房间的 lysate 肌动朊聚合在在 vitro 试金没有房间。BCL2 和 F 肌动朊的共焦的 immunofluorescent 本地化在一致地传播期间证明 BCL2 的那增加的表情导致了增加的 F 肌动朊聚合。因此, BCL2 和 gelsolin 建筑群的形成(它可能包含另外的蛋白质) 看起来在房间粘附和移植的规定起一个关键作用。与癌症转移给房间活动性的确定的关联,这结果可以解释在一些肿瘤房间类型的 BCL2 的表示为什么为转移减少潜力并且与改进耐心的预后被联系。 | Hengning Ke Vandy I Parron Jeff Reece Jennifer Y Zhang Steven K Akiyama John E French | 2010 | Cell Research2010，20，4： | 3 |
| 2 | Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy显示文摘AIM:To investigate whether tumor marker staining can improve the sensitivity of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)to diagnose pancreatic malignancy. METHODS:Patients who underwent EUS-FNA were retrospectively identified.Each EUS-FNA specimen was evaluated by routine cytology and stained for tumor markers p53,Ki-67,carcinoembryonic antigen(CEA) and CA19-9.Sensitivity,specificity,positive and negative predictive values(PPV and NPV),and positive and negative likelihood ratios(PLR and NLR)were calculated in order to evaluate the performance of each test to detect malignancy. RESULTS:Sixty-one specimens had complete sets of stains,yielding 49 and 12 specimens from pancreatic adenocarcinomas and benign pancreatic lesions due to pancreatitis,respectively.Cytology alone had sensitivity and specificity of 41%and 100%to detect malignancy, respectively.In 46%of the specimens,routine cytology alone was deemed indeterminate.The addition of either p53 or Ki-67 increased the sensitivity to 51%and 53%,respectively,with perfect specificity,PPV and PLR (100%,100%and infinite).Both stains in combination increased the sensitivity to 57%.While additional staining with CEA and CA19-9 further increased the sensitivity to 86%,the specificity,PPV and PLR were significantly reduced(at minimum 42%,84%and 1,respectively).Markers in all combinations performed poorly as a negative test(NPV 26%to 47%,and NLR 0.27 and 0.70).CONCLUSION:Immunohistochemical staining for p53 and Ki-67 can improve the sensitivity of EUS-FNA to diagnose pancreatic adenocarcinoma. | Alexander W Jahng Sonya Reicher David Chung Donna Varela Rahul Chhablani Anil Dev Binh Pham Jose Nieto Rose J Venegas Samuel W French Bruce E Stabile Viktor E Eysselein | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 3 |
| 3 | Common risk factors in the returns on stocks and bonds显示文摘 | Fama E French K | 1993 | Journal of Financial Economics1993，339，1： | 2 |
| 4 | The Cross Section of Expected Stock Returns显示文摘 | Farm E F French K R | 1992 | Journal of Finance1992，47，： | 1 |
| 5 | Early Exercise of American Index Options 显示文摘 | Maberly E D | 1992 | Journal of Financial Research1992，15，： | 1 |
| 6 | The cross-section of expected stock returns显示文摘 | Fama E F French K R | 1992 | Journal of Finance1992，47，2： | 1 |
| 7 | Industry costs of equity 显示文摘 | Fama E F French K R | 1997 | Journal of Financial Economics1997，43，2： | 1 |
| 8 | Development of new antiepileptic drugs:challenges,incentives,and recent advances显示文摘 | Perucca E French J Bialer M | 2007 | Lancet Neurol2007，6，9： | 1 |
| 9 | Portfolio performance and the interaction between systematic risk, firm size and price -earnings ratio 显示文摘 | Fama E F French S | 1992 | Journal of Finance1992，，： | 1 |
| 10 | Size and book-to-market factors in earnings and returns显示文摘 | Fama E French K | 1995 | Journal of Finance1995，50，1： | 1 |
| 11 | Fas and Fas ligand in embryos and adult mice:ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover显示文摘 | FRENCH L E HAHNE M VIARD I | 1996 | J Cell Biol1996，133，2： | 1 |
| 12 | Nonlinear mechanisms for gain adaptation in locust photoreceptors显示文摘 | / Pece A E C French A S Korenberg M J | 1990 | Biophys J1990，57，11： | 1 |
| 13 | Vibra-tional spectroscopy of aluminum nitride显示文摘 | McNeil L E Grimsditch M French R H | 1993 | J AmCeram Soc1993，76，： | 1 |
| 14 | The cross-section of expected stock returns显示文摘 | Fama E F French K R | 1992 | Journal of Finance1992，47，2： | 1 |
| 15 | Meat quality of steers finished on autumn grass, grass silage or concen trate-based diets显示文摘 | French P O'Riordan E G Monahan F Letal | 2000 | Meat Science2000，56，： | 1 |
| 16 | Common Risk Factors In the Re- turns on Stocks and Bonds 显示文摘 | Fama E F K R French | 1993 | Journal of Financial Eco- nomics1993，33，1： | 1 |
| 17 | Value versus growth: The international evidence 显示文摘 | FAMA E F FRENCH K | 1998 | Journal of Finance1998，53，6： | 1 |
| 18 | The cross section of expected stock returns 显示文摘 | FAMA E F FRENCH K R | 1992 | Journal of Finance1992，47，2： | 1 |
| 19 | The association between HIV and antituberculosis drug resistance 显示文摘 | FRENCH C E GLYNN J R KRUIJSHAAR M E | 2008 | Eur Respir J2008，32，6： | 1 |
| 20 | A compar-ison of instruments and laboratories used to measure milk urea nitrogen in bulk-tank samples显示文摘 | KOHN R A FRENCH K R RUSSEK-COHEN E | 2004 | J Dairy Sci2004，87，6： | 1 |
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