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| 1 | Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy显示文摘AIM:To investigate whether tumor marker staining can improve the sensitivity of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)to diagnose pancreatic malignancy. METHODS:Patients who underwent EUS-FNA were retrospectively identified.Each EUS-FNA specimen was evaluated by routine cytology and stained for tumor markers p53,Ki-67,carcinoembryonic antigen(CEA) and CA19-9.Sensitivity,specificity,positive and negative predictive values(PPV and NPV),and positive and negative likelihood ratios(PLR and NLR)were calculated in order to evaluate the performance of each test to detect malignancy. RESULTS:Sixty-one specimens had complete sets of stains,yielding 49 and 12 specimens from pancreatic adenocarcinomas and benign pancreatic lesions due to pancreatitis,respectively.Cytology alone had sensitivity and specificity of 41%and 100%to detect malignancy, respectively.In 46%of the specimens,routine cytology alone was deemed indeterminate.The addition of either p53 or Ki-67 increased the sensitivity to 51%and 53%,respectively,with perfect specificity,PPV and PLR (100%,100%and infinite).Both stains in combination increased the sensitivity to 57%.While additional staining with CEA and CA19-9 further increased the sensitivity to 86%,the specificity,PPV and PLR were significantly reduced(at minimum 42%,84%and 1,respectively).Markers in all combinations performed poorly as a negative test(NPV 26%to 47%,and NLR 0.27 and 0.70).CONCLUSION:Immunohistochemical staining for p53 and Ki-67 can improve the sensitivity of EUS-FNA to diagnose pancreatic adenocarcinoma. | Alexander W Jahng Sonya Reicher David Chung Donna Varela Rahul Chhablani Anil Dev Binh Pham Jose Nieto Rose J Venegas Samuel W French Bruce E Stabile Viktor E Eysselein | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 3 |
| 2 | Impaired CTLA-4 responses in COPD are associated with systemic inflammation显示文摘 | Dino BA Tan Sonia Fernandez PatriciaPrice Martyn A French Philip J Thompson Yuben P Moodley | 2014 | Cellular & Molecular Immunology2014，11，6： | 3 |
| 3 | Primary angioplasty and selection bias inpatients presention late (>12 h) after onset of chest pain and ST elevation myocardial infarction显示文摘 | ELAD Y FRENCH W J SHAVELLE D M | 2002 | J Am Coll Cardiol2002，39，5： | 2 |
| 4 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 5 | Polycrystalline silicon strain sensors 显示文摘 | French P J Evans A G R | 1985 | Sensors and Actuators A1985，7，： | 2 |
| 6 | Hyperbaric oxygen therapy for acute ischemic stroke显示文摘 | Bennett MH Wasiak J French C | 2006 | Stroke2006，37，： | 1 |
| 7 | Development of new antiepileptic drugs:challenges,incentives,and recent advances显示文摘 | Perucca E French J Bialer M | 2007 | Lancet Neurol2007，6，9： | 1 |
| 8 | Abnormal vaginal discharge:what does and does not work in treating underlying causes显示文摘 | French L Horton J Matousek M | 2004 | J Fam Pract2004，53，： | 1 |
| 9 | Galvanic porous silicon formation without external contacts显示文摘 | ASHRUF C M A FRENCH P J BRESSERS P M M C | 1999 | Sensors and Actuators A1999，74，13： | 1 |
| 10 | Physicochemical aspects of controlled release of substituted benzoic and naphthoic acids from Carbopol gels显示文摘 | French D L Himmelstein K J Manger J M | 1995 | J Controlled Release1995，37，： | 1 |
| 11 | Nonlinear mechanisms for gain adaptation in locust photoreceptors显示文摘 | / Pece A E C French A S Korenberg M J | 1990 | Biophys J1990，57，11： | 1 |
| 12 | Chronic cough - the spectrum and frequency of cause, key components of the diagnostic evaluation, and outcome of specific therapy 显示文摘 | IRWIN R S CURLEY F J FRENCH C L | 1990 | Am Rev Respir Dis1990，141，3： | 1 |
| 13 | Cryoprecipitate for the correction of co- agulopathy associated with liver disease 显示文摘 | French C J Bellomo R Angus P | 2003 | Anaesth Intensive Care2003，31，4： | 1 |
| 14 | The role of information inepilepsy显示文摘 | Vezzani A French J Bartfai T | 2011 | Nat Rev Neurol2011，7，1： | 1 |
| 15 | Sirt1 is involved in energy metabolism:the role of chronic ethanol feeding and resveratrol显示文摘 | Oliva J French BA Li J | 2008 | Exp Mol Pathol2008，85，3： | 1 |
| 16 | Adjunctive perampanel forrefractory partial-onset seizures : randomized phase III study 304显示文摘 | French J A Krauss G L Biton V | 2012 | Neurology2012，79，6： | 1 |
| 17 | Behavioral correlates of individual differences in road traffic rash risk: an examination of methods and findings 显示文摘 | ELANDER J WEST R FRENCH D | 1993 | Psychology Bull1993，113，： | 1 |
| 18 | Comparision of pentastarch and Hartmann's solution for volume preloading in spinal anesthesia for elective caesarean section显示文摘 | French GWG White JB Howell S J | 1999 | Br J Anesth1999，83，： | 1 |
| 19 | The association between HIV and antituberculosis drug resistance 显示文摘 | FRENCH C E GLYNN J R KRUIJSHAAR M E | 2008 | Eur Respir J2008，32，6： | 1 |
| 20 | Protein--based therapeutic approaches targeting death receptors显示文摘 | French L E Tschopp J | 2003 | J Cell Death Differ2003，10，1： | 1 |
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