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| 1 | Multicenter evaluation of recurrence in endoscopic submucosal dissection and endoscopic mucosal resection in the colon:A Western perspective显示文摘BACKGROUND While colon endoscopic mucosal resection(EMR)is an effective technique,removal of larger polyps often requires piecemeal resection,which can increase recurrence rates.Endoscopic submucosal dissection(ESD)in the colon offers the ability for en bloc resection and is well-described in Asia,but there are limited studies comparing ESD vs EMR in the West.AIM To evaluate different techniques in endoscopic resection of large polyps in the colon and to identify factors for recurrence.METHODS The study is a retrospective comparison of ESD,EMR and knife-assisted endoscopic resection performed at Stanford University Medical Center and Veterans Affairs Palo Alto Health Care System between 2016 and 2020.Knife-assisted endoscopic resection was defined as use of electrosurgical knife to facilitate snare resection,such as for circumferential incision.Patients≥18 years of age undergoing colonoscopy with removal of polyp(s)≥20 mm were included.The primary outcome was recurrence on follow-up.RESULTS A total of 376 patients and 428 polyps were included.Mean polyp size was greatest in the ESD group(35.8 mm),followed by knife-assisted endoscopic resection(33.3 mm)and EMR(30.5 mm)(P<0.001).ESD achieved highest en bloc resection(90.4%)followed by knife-assisted endoscopic resection(31.1%)and EMR(20.2%)(P<0.001).A total of 287 polyps had follow-up(67.1%).On follow-up analysis,recurrence rate was lowest in knife-assisted endoscopic resection(0.0%)and ESD(1.3%)and highest in EMR(12.9%)(P=0.0017).En bloc polyp resection had significantly lower rate of recurrence(1.9%)compared to non-en bloc(12.0%,P=0.003).On multivariate analysis,ESD(in comparison to EMR)adjusted for polyp size was found to significantly reduce risk of recurrence[adjusted hazard ratio 0.06(95%CI:0.01-0.57,P=0.014)].CONCLUSION In our study,EMR had significantly higher recurrence compared to ESD and knife-assisted endoscopic resection.We found factors including resection by ESD,en bloc removal,and use of circumferential incision were associated with significantly decreased recurrence.While further studies are needed,we have demonstrated the efficacy of ESD in a Western population. | Mike T Wei Margaret J Zhou Andrew A Li Andrew Ofosu Joo Ha Hwang Shai Friedland | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，6： | 2 |
| 2 | Water-aided colonoscopy: a systematic review显示文摘 | Felix W. Leung Arnaldo Amato Christian Ell Shai Friedland Judith O. Harker Yu-Hsi Hsieh Joseph W. Leung Surinder K. Mann Silvia Paggi Jürgen Pohl Franco Radaelli Francisco C. Ramirez Rodelei Siao-Salera Vittorio Terruzzi | 2012 | Gastrointestinal Endoscopy2012，，3： | 2 |
| 3 | Myeloid cells in infantile hemangioma显示文摘 | Ritter MR Reinisch J Friedlander SF | 2006 | Am J Pathol2006，168，： | 1 |
| 4 | Tenascin-C expression by angiogenic vessels in human astrocytomas and by human brain endothelial cells in vitro显示文摘 | Friedlander DR Dosik J | 1996 | Cancer Res1996，56，2： | 1 |
| 5 | Local and systemic radiation for palliation of metastatic disease显示文摘 | Friedland J | 1999 | Urol Clin North Am1999，26，2： | 1 |
| 6 | Direction finding using spatial smoothing with interpolated arrays 显示文摘 | FRIEDLANDER B WEISS A J | 1993 | IEEE Transaction on Signal Processing1993，41，4： | 1 |
| 7 | Eigenstructure methods for direction finding with sensor gain and phase uncertainties 显示文摘 | Weiss A J Friedlander B | 1990 | Circutis Systems Signal Process1990，9，3： | 1 |
| 8 | Meta - analysis of randomized controlled trials of intracoronary versus intravenous adminis- tration of glycoprotein Ilb/IIIa inhibitors during percutaneous coronary intervention for acute coronary syndrome 显示文摘 | Friedland S Eisenberg M J Shimony A | 2011 | Am J Cardiol2011，108，9： | 1 |
| 9 | EAP actions and options显示文摘 | Masi D A Friedland S J | 1988 | Personnel Journal1988，67，6： | 1 |
| 10 | Eigenstructure methods for direction finding with sensor gain and phase uncertainties显示文摘 | WEISS A J FRIEDLANDER B | 1990 | Circuits Syst Signal Processing1990，9，2： | 1 |
| 11 | Eigenstructure methods for direc- tion finding with sensor gain and phase uncertainties显示文摘 | Weiss A J Friedlander B | 1993 | Cir- cuits Syst Signal Processing1993，12，1： | 1 |
| 12 | Direction finding in the presence of mutual coupling显示文摘 | Friedlander B Weiss A J | 1991 | IEEE Trans on AP1991，39，3： | 1 |
| 13 | Effects of modeling errors on the resolution threshold of the MUSIC algorithm 显示文摘 | WEISS A J Friedlander B | 1994 | IEEE Transactions on Signal Processing1994，42，6： | 1 |
| 14 | Direction Finding Using Spatial Smoothing with Interpolated Array显示文摘 | Friedlander B Weiss A J | 1992 | IEEE Transactions on Aerospace and Electronic Systems1992，28，2： | 1 |
| 15 | A study evaluating the efficacy,safety,and tolerability of ertapenem versus ceftriaxone for the treatment of community-acquired pneumonia in adults显示文摘 | Ortiz-Ruiz G Caballero-Lopez J Friedland I | | 0，，08： | 1 |
| 16 | Direction finding in the presence of mutual coupling显示文摘 | FRIEDLANDER B WEISS A J | 1991 | IEEE Transactions on Antennas and Propagation1991，39，3： | 1 |
| 17 | Range and bearing estimation using polynomial rooting显示文摘 | Weiss A J Friedlander B | 1993 | IEEE J Ocean Engr1993，18，2： | 1 |
| 18 | Student Perception on the Effectiveness ofMidterm Feedback to Modify College Instruction 显示文摘 | Friedlander J | 1978 | Journal of Educational Research1978，71，3： | 1 |
| 19 | Endoscopy mastectomy and breast reconstruction: endoscopic breast surgery显示文摘 | Sundin J Bakshandeh N | 1995 | Aesth Plast Surg1995，19，1： | 1 |
| 20 | A study eval uating the efficacy, safety, and tolerability of ertapenem versus cef triaxone for the treatment of community-acquired pneumonia in adults显示文摘 | Caballero-Lopez J Friedland IR | 2002 | Clin Infect Dis2002，34，8： | 1 |
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