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| 1 | Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome显示文摘The use of small interfering RNAs(si RNAs)has been under investigation for the treatment of several unmet medical needs,including acute lung injury/acute respiratory distress syndrome(ALI/ARDS)wherein si RNA may be implemented to modify the expression of pro-inflammatory cytokines and chemokines at the m RNA level.The properties such as clear anatomy,accessibility,and relatively low enzyme activity make the lung a good target for local si RNA therapy.However,the translation of si RNA is restricted by the inefficient delivery of si RNA therapeutics to the target cells due to the properties of naked si RNA.Thus,this review will focus on the various delivery systems that can be used and the different barriers that need to be surmounted for the development of stable inhalable si RNA formulations for human use before si RNA therapeutics for ALI/ARDS become available in the clinic. | Makhloufi Zoulikha Qingqing Xiao George Frimpong Boafo Marwa A.Sallam Zhongjian Chen Wei He | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 7 |
| 2 | Neurocysticercosis:A case report and brief review显示文摘Neurocysticercosis(NCC) is one of the seven neglected endemic zoonoses targeted by the World Health Organization.It is considered a common infection of the nervous system caused by the Tanenia solium and is known to be the primary cause of preventable epilepsy in many developing countries.NCC is commonly resulted by the ingestion of Tanenia solium eggs after consuming undercooked pork,or contaminated water.The parasite can grow in the brain and spinal cord within the nervous system,causing severe headache and seizures beside other pathological manifestations.Immigration and international travel to endemic countries has made this disease common in the United States.NCC can be diagnosed with computed tomography and magnetic resonance imaging of the brain.The treatment of the NCC including cysticidal drugs(eg.,albendazole and praziquantel),and neurosurgical procedure,depending upon a the situation.A patient of Asian origin came to our clinic with complaints of dizziness,headaches and episodes seizures for the past twelve years without proper diagnosis.The computed tomography and magnetic resonance imaging scans indicated multilobulated cystic mass in the brain with the suspicion of neurocysticercosis. | Syed A.A.Rizvi Ayman M.Saleh Hanns Frimpong Hussain M.Al Mohiy Jasmin Ahmed Ronda D.Edwards Sultan S.Ahmed | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，1： | 7 |
| 3 | 用植物油作为绝缘液降低变压器失火风险显示文摘每年,总有一些变压器发生故障导致火灾。由于变压器的绝缘液是可燃物,火灾可以持续数小时或数天。火、烟以及可能发生的液体泄漏,不仅会危及人体和动物健康,破坏环境,也会损毁邻近的设备。而且,此类事故会影响相关方的声誉和资产负债情况。因此,业内长期高度重视失火风险较低的变压器。ABB引进了高油酸、高燃点的天然酯绝缘液BIOTEMP,相比于传统使用的矿物油,BIOTEMP可极大地降低起火和火灾蔓延的风险。作为市场上最安全的变压器绝缘液之一,使用BIOTEMP的变压器究竟有何与众不同呢? | George Frimpong Stephane Page Kjell Carrander Don Cherry | 2014 | 电气制造2014，0，5： | 2 |
| 4 | Metal phenolic network-stabilized nanocrystals of andrographolide to alleviate macrophage-mediated inflammation in-vitro显示文摘Macrophages play a crucial role in initiating,maintaining,and resolving inflammation through the phenotypic shift,inducing or inhibiting the production of inflammatory cytokines.Therefore,macrophages are potential targets for treating inflammatory diseases.Andrographolide(AND)is a potent anti-inflammatory drug that can reduce pro-inflammatory cytokines and suppress NF-κB/MAPK pathway in activated macrophages.Although AND has many medicinal properties,its lower water solubility and first-pass effect in the liver have hindered its clinical application.In this context,by using a metal phenolic network as a stabilizer,we designed and prepared highly stabilized AND nanocrystals(AND-MPN Ns)with high drug loading capacity to facilitate the clinical application of AND.Our findings showed that AND-MPN Ns could be used to enhance the anti-inflammation in-vitro via macrophage polarization,reducing proinflammatory cytokines IL-6 and TNF-α,and suppressing the NF-κB signaling pathway activation.The results demonstrated the potential of AND-MPN Ns to combat inflammatory diseases effectively. | Kosheli Thapa Magar George Frimpong Boafo Makhloufi Zoulikha Xiaohong Jiang Xiaotong Li Qingqing Xiao Xuyang Xing Xiaochun Wang Lifang Fan Zhenfeng Wu Wei He | 2023 | Chinese Chemical Letters2023，34，1： | 2 |
| 5 | When is Inflation Harmful? Esti-mating the Threshold Effect for Ghana 显示文摘 | Oteng-Abayie E F Frimpong J M | 2010 | American Journal of Eco-nomics and Business Administration2010，2，3： | 1 |
| 6 | Resistance to an- timicrobial drugs in Ghana 显示文摘 | Newman M J Frimpong E Donkor ES | 2011 | Infec Drug Resist2011，4，： | 1 |
| 7 | Hybrid simulation for Oil-solid-water separation in oil sands production显示文摘 | Changirwa R Rockwell M C Frimpong S | 1999 | Minerals Engineering1999，12，12： | 1 |
| 8 | Resistance toantimicrobial drugs in Ghana 显示文摘 | Newman MJ Frimpong E Donkor ES | 2011 | Infect Drug Resist2011，4，： | 1 |
| 9 | Causes of delay and cost overruns in construction of groundwater projects in a developing countries: Ghana as a case study显示文摘 | Yaw Frimpong Jacob Oluwoye Lynn Crawford | 2003 | International Journal of Project Management2003，，21： | 1 |
| 10 | Effect of antimicrobial agents,especially fosfomycin,on the production and release of vero toxin by enterohaemorrhagic Escherichia coli O157:H7显示文摘 | YOH M FRIMPONG E K HONDA T | 1997 | FEMS Immunol Med Microbiol1997，19，1： | 1 |
| 11 | Intelligent cable shovel excavation modeling and simulation 显示文摘 | Frimpong S Hu Y | 2008 | Canadian Metallurgical Quarterly2008，，1： | 1 |
| 12 | Health In- formation Technology Capacity at Federally Qualified Health Centers: a mechanism for improving quality of care 显示文摘 | Frimpong JA Jackson BE Stewart LM | 2013 | BMC Health Serv Res2013，，13： | 1 |
| 13 | Modelling and Forecasting Volatility of Returns on the Ghana Stock Exchange Using Garch Models显示文摘 | Frimpong Joseph Magnus Oteng-Abayie Eric Fosu | 2006 | Directory of Open Access Journals2006，3，10： | 1 |
| 14 | The decomposition of cocoa leaves and their effect on phosphorus in dynamics in tropical soil显示文摘 | Ofori Frimpong K Rowell DL | 1999 | European Journal of Soil Science1999，50，1： | 1 |
| 15 | Resistance to Antimicrobial Drugs in Ghana显示文摘 | Newman M J Frimpong E Donkor E S | 2011 | Infection and Drug Resistance2011，4，： | 1 |
| 16 | The prevalence of metabolic syndrome and its predominant compo- nents among pre - and postmenopausal Ghanaian women显示文摘 | ARTHUR FK ADU FRIMPONG M OSEI YEBOAH J | 2013 | BMC Res Notes2013，6，： | 1 |
| 17 | Intelligent modeling :advances in open pit mine design and optimization research显示文摘 | Frimpong S Asa E Szymanski J | 2002 | International Journal of Surface Mining Reclamationand Environment2002，16，2： | 1 |
| 18 | Liposome-based delivery of biological drugs显示文摘Biological drugs are attracting tremendous attention in disease treatment. However, their application is significantly limited by their inherent properties, such as high hydrophilicity, poor membranepermeability, low stability, and larger size. Liposome-based drug delivery systems are emerging as promising tools to improve their delivery, owing to their ability to reduce toxicity, improve bioavailability,and enhance the therapeutic efficacy of the drug by optimizing delivery to the specific target site. Here,we reviewed the types of liposomes and their applications as carriers for biological drugs to treat various diseases, emphasized the commercial products, and ultimately provided perspectives in this field. | Kosheli Thapa Magar George Frimpong Boafo Xiaotong Li Zhongjian Chen Wei He | 2022 | Chinese Chemical Letters2022，33，2： | 1 |
| 19 | Void Effects on the Inter- laminar Shear Strength of Unidirectional Graphite-Fiber- Reinforced Composites 显示文摘 | BOWIES K J FRIMPONG S J | 1992 | Journal of Composite Materi- als1992，，10： | 1 |
| 20 | Recovery of problems at nanogram per gram concentrations 显示文摘 | Frimpong A Fryer B J Longcrich H P | 1995 | Analyst1995，120，： | 1 |
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