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| 1 | 如何将小胶质细胞向有益功能重编程显示文摘小胶质细胞是一种非神经起源的脑细胞,它可以协调对各种损伤的炎症反应,包括围产期脑中的缺氧/缺血或母体/胎儿感染。实验研究已经证明小胶质细胞能够识别病原体或受损细胞,从而激活细胞毒性反应,从而加剧脑损伤。然而,小胶质细胞在对损伤的反应中显示出巨大的可塑性,并且还可以促进炎症和组织再生的消退。尽管小胶质细胞在脑病理学中起着关键作用,对于控制小胶质细胞不同表型的细胞机制的研究却才刚刚崭露头角。这篇文章回顾了推动小胶质细胞向有益功能发展的新兴策略,总结了涉及表型转换潜在的分子机制的研究。这些方法包括使用药理学试剂,细胞因子,脂质信使或微小RNA,以及免疫调节细胞的营养方法或疗法来处理小胶质细胞。对小胶质细胞向促再生功能重编程相关的分子机制的分析指出,能量代谢在塑造小胶质细胞功能中起到核心作用。因此,可以通过调控代谢途径,来预防炎性小胶质细胞的有害作用并控制脑病症中的过度炎症反应。 | Fumagalli M Lombardi M Gressens P Verderio C 聂昊 | 2018 | 神经损伤与功能重建2018，13，10： | 10 |
| 2 | Frailty,sarcopenia and cachexia in heart failure patients:Different clinical entities of the same painting显示文摘Heart Failure(HF)in elderly patients is a systemic syndrome where advanced age,comorbidities with organ system deterioration,frailty and impaired cognition significantly impact outcome.Cardiac cachexia,sarcopenia and frailty despite overlap in definitions are different clinical entities that frequently coexist in HF patients.However,these co-factors often remain unaddressed,resulting in poor quality-of-life,prolonged physical disability and exercise intolerance and finally with higher rehospitalization rates and mortality.Strategy aim to increase muscle mass and muscle strength and delay the occurrence of frailty state appear essential in this regard.Common HF drugs therapy(b-blockers,angiotensinconverting enzyme inhibitors)and prescription of physical exercise program remain the cornerstone of therapeutic approach in HF patients with new promising data regarding nutritional supplementation.However,the treatment of all these conditions still remain debated and only a profound knowledge of the specific mechanisms and patterns of disease progression will allow to use the appropriate therapy in a given clinical setting.For all these reasons we briefly review current knowledge on frailty,sarcopenia and cachexia in HF patients with the attempt to define clinically significant degrees of multiorgan dysfunction,specific'red alert'thresholds in clinical practice and therapeutic approach. | Matteo Beltrami Carlo Fumagalli Massimo Milli | 2021 | World Journal of Cardiology2021，13，1： | 7 |
| 3 | Cytoskeleton reorganization and ultrastructural damage induced by gliadin in a three-dimensional in vitro model显示文摘AIM: To evaluate the interplay between gliadin and LoVo cells and the direct effect of gliadin on cytoskeletal patterns.METHODS: We treated LoVo multicellular spheroids with digested bread wheat gliadin in order to investigate their morphology and ultrastructure (by means of light microscopy and scanning electron microscopy), and the effect of gliadin on actin (phalloidin fluorescence)and the tight-junction protein occludin and zonula occluden-1.RESULTS: The treated spheroids had deep holes and surface blebs, whereas the controls were smoothly surfaced ovoids. The incubation of LoVo spheroids with gliadin decreased the number of intracellular actin filaments, impaired and disassembled the integrity of the tight-junction system.CONCLUSION: Our data obtained from an 'in vivolike' polarized culture system confirm the direct noxious effect of gliadin on the cytoskeleton and tight junctions of epithelial cells. Unlike two-dimensional cell culture systems, the use of multicellular spheroids seems to provide a suitable model for studying cell-cell interactions. | Ersilia Dolfini Leda Roncoroni Luca Elli Chiara Fumagalli Roberto Colombo Simona Ramponi Fabio Forlani Maria Teresa Bardella | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 4 | Incidence and treatment of mediastinal leakage after esophagectomy:Insights from the multicenter study on mediastinal leaks显示文摘BACKGROUND Mediastinal leakage(ML) is one of the most feared complications of esophagectomy. A standard strategy for its diagnosis and treatment has beendifficult to establish because of the great variability in their incidence and mortality rates reported in the existing series.AIM To assess the incidence, predictive factors, treatment, and associated mortality rate of mediastinal leakage using the standardized definition of mediastinal leaks recently proposed by the Esophagectomy Complications Consensus Group(ECCG).METHODS Seven Italian surgical centers(five high-volume, two low-volume) affiliated with the Italian Society for the Study of Esophageal Diseases designed and implemented a retrospective study including all esophagectomies(n = 501) with intrathoracic esophagogastric anastomosis performed from 2014 to 2017.Anastomotic MLs were defined according to the classification recently proposed by the ECCG.RESULTS Fifty-nine cases of ML were recorded, yielding an overall incidence of 11.8%(95%CI: 9.1%-14.9%). The surgical approach significantly influenced the occurrence of ML: the proportion of leakage was 10.5% and 9% after open and hybrid esophagectomy(HE), respectively, and doubled(20%) after totally minimally invasive esophagectomy(TMIE)(P = 0.016). No other predictive factors were found. The 30-and 90-d overall mortality rates were 1.4% and 3.2%,respectively; the 30-and 90-d leak-related mortality rates were 5.1% and 10.2%,respectively; the 90-d mortality rates for TMIE and HE were 5.9% and 1.8%,respectively. Endoscopy was the first-line treatment in 49% of ML cases, with the need for retreatment in 17.2% of cases. Surgery was needed in 44.1% of ML cases.Endoscopic treatment had the lowest mortality rate(6.9%). Removal of the gastric tube with stoma formation was necessary in 8(13.6%) cases.CONCLUSION The incidence of ML after esophagectomy was high mainly in the TMIE group.However, the general and specific(leak-related) mortality rates were low. Early treatment(surgical or endoscopic) of severe leaks is mandatory to limit related mortality. | Uberto Fumagalli Gian Luca Baiocchi ANDrea Celotti Paolo Parise ANDrea Cossu Luigi Bonavina Daniele Bernardi Giovanni de Manzoni Jacopo Weindelmayer Giuseppe Verlato Stefano Santi Giovanni Pallabazzer Nazario Portolani Maurizio Degiuli Rossella Reddavid Stefano de Pascale | 2019 | World Journal of Gastroenterology2019，25，3： | 3 |
| 5 | Associations between cardiac arrhythmia,incident disability in activities of daily living and physical performance:the ILSA study显示文摘Background Cardiac arrhythmias are common conditions in older people.Unfortunately,there is limited literature on associations between cardiac arrhythmias and physical performance or disability.We therefore aimed to prospectively investigate associations between cardiac arrhythmias and changes in disability and physical performance during 8 years of follow-up,using data from the Italian Longitudinal Study on Aging(ILSA).Methods Cardiac arrhythmias diagnosis was posed through a screening phase,confirmed by a physician.The onset of disability in activities of daily living(ADL)and the changes in several physical performance tests during follow-up were considered as outcomes.Fully-adjusted and propensity-score Cox Proportional Hazard models and mixed models were used for exploring associations between cardiac arrhythmia and the outcomes of interest.Results The prevalence of cardiac arrhythmia at baseline was 23.3%.People reporting cardiac arrhythmia at the baseline were significantly older,more frequently male,smokers and reported a higher presence of all medical conditions investigated(hypertension,heart failure,angina,myocardial infarction,diabetes,stroke),but no difference in dementia,Parkinsonism,cognitive or mood disorder.Cardiac arrhythmia at baseline was significantly associated with the incidence of disability in ADL(HR=1.23;95%:CI:1.01–1.50;P=0.0478 in propensity score analyses;HR=1.28;95%CI:1.01–1.61;P=0.0401 in fully adjusted models).Cardiac arrhythmia at baseline was also associated with a significant worsening in balance test(P=0.0436).Conclusions The presence of cardiac arrhythmia at baseline was associated with a significant higher risk of disability and of worsening in some physical performance tests,particularly those relating to balance.Screening and frequently assessing physical performance in older people affected by cardiac arrhythmia can be important to prevent a loss of physical performance,with further,potential,complications of medical management. | Marianna Noale Nicola Veronese Lee Smith Andrea Ungar Stefano Fumagalli Stefania Maggi the Italian Longitudinal Study on Aging Working Group | 2020 | Journal of Geriatric Cardiology2020，17，3： | 3 |
| 6 | LED Failure Modes Implications in Ex-e Applications显示文摘 | Roberto Sebastiano Faranda Lorenzo Fame Kim Fumagalli | 2015 | Journal of Energy and Power Engineering2015，9，11： | 2 |
| 7 | Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence显示文摘 | Juan C. Acosta Ana O’Loghlen Ana Banito Maria V. Guijarro Arnaud Augert Selina Raguz Marzia Fumagalli Marco Da Costa Celia Brown Nikolay Popov Yoshihiro Takatsu Jonathan Melamed Fabrizio d’Adda di Fagagna David Bernard Eva Hernando Jesús Gil | 2008 | Cell2008，，6： | 2 |
| 8 | Neoadjuvant radiotherapy dose escalation for locally advanced rectal cancers in the new era of radiotherapy:A review of literature显示文摘BACKGROUND The standard treatment of locally advanced rectal cancers(LARC)consists on neoadjuvant chemoradiotherapy followed by total mesorectal excision.Different data in literature showed a benefit on tumor downstaging and pathological complete response(pCR)rate using radiotherapy dose escalation,however there is shortage of studies regarding dose escalation using the innovative techniques for LARC(T3-4 or N1-2).AIM To analyze the role of neoadjuvant radiotherapy dose escalation for LARC using innovative radiotherapy techniques.METHODS In December 2020,we conducted a comprehensive literature search of the following electronic databases:PubMed,Web of Science,Scopus and Cochrane library.The limit period of research included articles published from January 2009 to December 2020.Screening by title and abstract was carried out to identify only studies using radiation doses equivalent dose 2 Gy fraction(EQD2)≥54 Gy and Volumetric Modulated Arc Therapy(VMAT),intensity-modulated radiotherapy or image-guided radiotherapy(IGRT)techniques.The authors’searches generated a total of 2287 results and,according to PRISMA Group(2009)screening process,21 publications fulfil selection criteria and were included for the review.RESULTS The main radiotherapy technique used consisted in VMAT and IGRT modality.The mainly dose prescription was 55 Gy to high risk volume and 45 Gy as prophylactic volume in 25 fractions given with simultaneous integrated boosts technique(42.85%).The mean pCR was 28.2%with no correlation between dose prescribed and response rates(P value≥0.5).The R0 margins and sphincter preservation rates were 98.88%and 76.03%,respectively.After a mean follow-up of 35 months local control was 92.29%.G3 or higher toxicity was 11.06%with no correlation between dose prescription and toxicities.Patients receiving EQD2 dose>58.9 Gy and BED>70.7 Gy had higher surgical complications rates compared to other group(P value=0.047).CONCLUSION Dose escalation neoadjuvant radiotherapy using innovative techniques is safe for LARC achieving higher rates of pCR.EQD2 doses>58.9 Gy is associated with higher rate of surgical complications. | Durim Delishaj Ilaria Costanza Fumagalli Stefano Ursino Agostino Cristaudo Francesco Colangelo Antonio Stefanelli Alessandro Alghisi Giuseppe De Nobili Romerai D’Amico Alessandra Cocchi Antonio Ardizzoia Carlo Pietro | 2021 | World Journal of Clinical Cases2021，9，30： | 2 |
| 9 | Thiol-peptide level and proteomic changes in response to cadmium toxicity in Oryza sativa L. roots显示文摘 | Roberta Aina Massimo Labra Pietro Fumagalli Candida Vannini Milena Marsoni Ulisse Cucchi Marcella Bracale Sergio Sgorbati Sandra Citterio | 2006 | Environmental and Experimental Botany2006，，3： | 2 |
| 10 | DNA degradation in avian faecal samples and feasibility of non-invasivegenetic studies of threatened capercaillie populations显示文摘 | Sébastien Regnaut Fran?oise S. Lucas Luca Fumagalli | 2006 | Conservation Genetics2006，，： | 2 |
| 11 | Quality of service provision in electric power distribution systems through reliability insurance显示文摘 | Fumagalli E Black J W Vogelsang I | 2004 | IEEE Trans on Power Systems2004，19，3： | 1 |
| 12 | Adult respiratory distress syndrome due to pulmonary and extrapulmonary causes: CT,clinical ,and funetional correlations显示文摘 | Goodman LR Fumagalli R Tagliabue P | 1999 | Radiology1999，213，2： | 1 |
| 13 | Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation显示文摘 | Fumagalli M Rossiello F Clerici M | | 0，，04： | 1 |
| 14 | Magnetic resonance imaging assessment of brain maturation in preterm neonates with punctate white matter lesions显示文摘 | Ramenghi LA Fumagalli M Righini A | 2007 | Neuroradiology2007，49，2： | 1 |
| 15 | Amplitude spectrum area to guide resuscitation-a retrospective analysis during out-of-hospital cardiopulmonary resuscitation in 609 patients with ventricular fibrillation cardiac arrest 显示文摘 | Ristagno G Li Y Fumagalli F | 2013 | Resuscitation2013，84，12： | 1 |
| 16 | Early vs latetracheotomy for prevention of pneumonia in mechanically ventilatedadult ICU patients: a randomized controlled trial 显示文摘 | Terragni PP Antonelli M Fumagalli R | 2010 | Journal of theAmerican Medical Association2010，303，15： | 1 |
| 17 | The expanding role of BDNF:a therapeutic target for Alzheimer' s disease显示文摘 | Racagni G Riva MA | 2006 | Pharmacoge-nomics J2006，6，1： | 1 |
| 18 | Bioavailability of a sustained release formulation of acipimox, following a single dose in healthy volunteers in fasting and fed conditions 显示文摘 | Efthymiopoulos C Benedetti S Fumagalli R | 1998 | J Pharm Sci1998，87，8： | 1 |
| 19 | Phenotypic changes,signaling pathway,andfunctional correlates of GPR17 -expressing neuralprecursor cells during oligodendrocytedifferentiation 显示文摘 | FUMAGALLI M DANIELE S LECCA D | 2011 | J Biol Chem2011，286，10： | 1 |
| 20 | Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice显示文摘 | Perego C Fumagalli S De Simoni MG | 2011 | Journal of neuroinflammation2011，8，： | 1 |
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