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| 1 | Beneficial mechanisms of aerobic exercise on hepatic lipid metabolism in non-alcoholic fatty liver disease显示文摘BACKGROUND:Non-alcoholic fatty liver disease(NAFLD)refers to any fatty liver disease that is not due to excessive use of alcohol.NAFLD probably results from abnormal hepatic lipid metabolism and insulin resistance.Aerobic exercise is shown to improve NAFLD.This review aimed to evaluate the molecular mechanisms involved in the beneficial effects of aerobic exercise on NAFLD.DATA SOURCE:We searched articles in English on the role of aerobic exercise in NAFLD therapy in Pub Med. | Rui Guo Emily C Liong Kwok Fai So Man-Lung Fung George L Tipoe | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，2： | 16 |
| 2 | Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future challenges显示文摘BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver injury and mortality in Western countries and China. However, as to date, there is no direct and effective therapy for this disease. The aim of this review is to analyze the key progress and challenges of main current therapeutic approaches in NAFLD. DATA SOURCE: We carried out a PubMed search of English-language articles relevant to NAFLD therapy. RESULTS: There are two major therapeutic strategies for NAFLD treatment: (1) lifestyle interventions (including weight reduction, dietary modification and physical exercise) and (2) pharmaceutical therapies. Lifestyle interventions, particularly chronic and moderate intensity exercise, are the most effective and recognized clinical therapies for NAFLD. For pharmaceutical therapies, although their effects and mechanisms have been extensively investigated in laboratory studies, they still need further tests and investigations in clinical human trials. CONCLUSION: Future advancement of NAFLD therapy should focus on the mechanistic studies on cell based and animal models and human clinical trials of exercise, as well as the combination of lifestyle intervention and pharmaceutical therapy specifically targeting main signaling pathways related to lipid metabolism, oxidative stress and inflammation. | Jia Xiao Rui Guo Man Lung Fung Emily C Liong George L Tipoe | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，2： | 14 |
| 3 | Klebsiella pneumoniae liver abscess: a new invasive syndrome显示文摘 | L Kristopher Siu Kuo-Ming Yeh Jung-Chung Lin Chang-Phone Fung Feng-Yee Chang | 2012 | The Lancet Infectious Diseases2012，，11： | 2 |
| 4 | Optimization of an impact drive mechanism based on real-coded genetic algorithm 显示文摘 | Ha J L Fung R F Han C F | 2005 | Sensors and Actuators2005，121，2： | 1 |
| 5 | Non-structural Fuzzy Decision Support System for Evaluation of Construction Safety Management System显示文摘 | Tam C M Tong Thomas K L Chiu Gerald C W Fung Ivan W H | 2002 | International Journal of Project Management2002，，20： | 1 |
| 6 | Optimization of an impact drive mechanism based on real-coded genetic algorithm显示文摘 | Ha J L Fung R F Han C F | | 0，，02： | 1 |
| 7 | Investor Legal Protection and Earnings Management:A Study of Chinese H-Shares and Hong Kong Shares显示文摘 | Fung S Y Su L Gul R J | 2013 | Journal of Accounting and Public Policy2013，32，05： | 1 |
| 8 | Flow of information in the light-triggered cyclic nucleotide cascade of vision显示文摘 | FUNG BK HURLEY JB Stryer L | 1981 | Proc NatlAcad Sci1981，78，： | 1 |
| 9 | Psychometric properties of the Chinese version of the mini-mental adjustment to cancer (MINI-MAC) scale显示文摘 | Ho S M Y Kam Fung W Chan C L W | 2003 | Psycho Oncol2003，12，6： | 1 |
| 10 | Fascin expression predicts survival after potentially curative resection of node-positive colon cancer显示文摘 | Chan C Jankova L Fung CL | | 0，，： | 1 |
| 11 | Environmental Quality and Its Changes, an Analysis Using NDVI显示文摘 | Fung T Siu W - L | 2000 | International Journal of Remote Sensing2000，22，： | 1 |
| 12 | Mechanical Properties of Short Glass Fibre Reinforced and Functionahzed Rubber-Toughened PET Blends显示文摘 | Fung K L Li R K Y | 2006 | Polym Test2006，25，7： | 1 |
| 13 | Lymphoma of the ocular adnexa: A study of 353 cases显示文摘 | Ferry JA Fung CY Zukerberg L | 2007 | Am J Surg Pathol2007，31，2： | 1 |
| 14 | Analysis of residual stresses and distortion in T-joint filler welds显示文摘 | Teng T L Fung C P Chang P H | 2001 | Intemational Journal of Pressure Vessel and Piping2001，78，： | 1 |
| 15 | Modeling of cavity stability and sand production in heavy oil reservoir显示文摘 | Fung L S K Wong R C K | 1996 | JCPT1996，35，2： | 1 |
| 16 | Early-stage bilateral breast cancer reated with breast conserving surgery and definitive irradiation: the University of Pennsylvania experience显示文摘 | Fung M C Scthultz D J Solin L J | 1997 | Radiat Oncol Biol Phys1997，38，5： | 1 |
| 17 | Finite Newton Method for Lagrangian Support Vector Machine Classification 显示文摘 | Fung G Mangasarian O L | 2003 | Neurocomputing2003，55，12： | 1 |
| 18 | Pharmacokinetics of interstitial delivery of carmustine,4-hydroxy-cyclophosphamide and paclitaxel from a biodegradable polymer implant in the monkey brain显示文摘 | FUNG L K EWEND M G SILLS A | 1998 | Cancer Res1998，58，4： | 1 |
| 19 | Diameter-defined Strahler system and connectivity matrix of the pulmonary arterial tree显示文摘 | Jiang Z L Kassab G S Fung Y C | 1994 | J Appl Physiol1994，76，2： | 1 |
| 20 | Zeolite MCM-49:athree-dimensional MCM-22 analogue synthesized by in situcrystallization显示文摘 | Lawton S L Fung A S Kennedy G J | 1996 | The Journal of Chemical Physics1996，100，： | 1 |
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