|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Early detection of hepatocellular carcinoma co-occurring with hepatitis C virus infection: A mathematical model显示文摘AIM: To develop a mathematical model for the early detection of hepatocellular carcinoma(HCC) with a panel of serum proteins in combination with α-fetoprotein(AFP).METHODS: Serum levels of interleukin(IL)-8, soluble intercellular adhesion molecule-1(s ICAM-1), soluble tumor necrosis factor receptor Ⅱ(s TNF-RⅡ), proteasome, and β-catenin were measured in 479 subjects categorized into four groups:(1) HCC concurrent with hepatitis C virus(HCV) infection(n = 192);(2) HCV related liver cirrhosis(LC)(n = 96);(3) Chronic hepatitis C(CHC)(n = 96); and(4) Healthy controls(n = 95). The R package and different modules for binary and multi-class classifiers based on generalized linear models were used to model the data. Predictive power was used to evaluate the performance of the model. Receiver operating characteristic curve analysis over pairs of groups was used to identify the best cutoffs differentiating the different groups. RESULTS: We revealed mathematical models, based on a binary classifier, made up of a unique panel of serum proteins that improved the individual performance of AFP in discriminating HCC patients from patients with chronic liver disease either with or without cirrhosis. We discriminated the HCC group from the cirrhotic liver group using a mathematical model(-11.3 + 7.38 × Prot + 0.00108 × s ICAM + 0.2574 ×β-catenin + 0.01597 × AFP) with a cutoff of 0.6552, which achieved 98.8% specificity and 89.1% sensitivity. For the discrimination of the HCC group from the CHC group, we used a mathematical model [-10.40 + 1.416 × proteasome + 0.002024 × IL + 0.004096 × s ICAM-1 +(4.251 × 10-4) × s TNF + 0.02567 ×β-catenin + 0.02442 × AFP] with a cutoff 0.744 and achieved 96.8% specificity and 89.7% sensitivity. Additionally, we derived an algorithm, based on a binary classifier, for resolving the multi-class classification problem by using three successive mathematical model predictions of liver disease status. CONCLUSION: Our proposed mathematical model may be a useful method for the early detection of different statuses of liver disease co-occurring with HCV infection. | Abdel-Rahman Nabawy Zekri Amira Salah El-Din Youssef Yasser Mabrouk Bakr Reham Mohamed Gabr Ola Sayed Ahmed Mostafa Hamed Elberry Ahmed Mahmoud Mayla Mohamed Abouelhoda Abeer A Bahnassy | 2016 | World Journal of Gastroenterology2016，22，16： | 2 |
| 2 | Numerical Analysis of Geosynthetic-reinforced and Pile-supported Earth Platforms over Soft Soil显示文摘 | HAN J GABR M A | 2002 | Journal of Geotechnical and Geoenvironmental Engineering2002，128，1： | 1 |
| 3 | Evaluation of water hyacinth as feed for ruminants显示文摘 | Abdelhamid A M Gabr A A | 1991 | Archives of Animal Nutrition1991，41，78： | 1 |
| 4 | Numerical Analysis of Geosynthetic-Reinforced and Pile-Supported Earth Platforms over Soft Soil 显示文摘 | Han J Gabr M A | 2002 | Journal of Geotechnical and Geoenvironmental Engineering2002，128，1： | 1 |
| 5 | LTBASE: A computer program for analysis of laterally loaded piers including base and slope effects 显示文摘 | GABR M A BORDEN R H | 1988 | Transportation Research Record1988，1169，： | 1 |
| 6 | Lateral load analysis of piers constructed on slopes 显示文摘 | GABR M A BORDEN R H | 1990 | Journal of Geotechnical Engineering ASCE1990，116，12： | 1 |
| 7 | Effect of Moderate Aerobic Training on Bone Metabolism Indices among Adult Humans显示文摘 | ALGHADIR A H ALY F A GABR S A | 2014 | Pakistan journal of medical sciences2014，30，4： | 1 |
| 8 | Compressibility Parameters of Municipal Solid Waste with Leachate Recirculation显示文摘 | Hossain M S Gabr M A Barlaz M A | 2003 | Journal of Geotechnical and Geoenvironmental Engineering ASCE2003，129，12： | 1 |
| 9 | Relationship of compressibility parameters to municipal solid waste decomposition显示文摘 | Hossain M S Gabr M A Barlaz M A | 2003 | Journal of Geotechnical and Geoenvironmental Engineering2003，129，12： | 1 |
| 10 | Solid leaehate recirculation显示文摘 | GABR M A HOSSAIN waste settlement with Geotechnicai News 2000 M S BARLAZ M A | 2000 | 18(2): 50 - 552000，18，2： | 1 |
| 11 | Numerical analysis of geosyntheticrein- forced and pile-supported earth platforms over soft soil 显示文摘 | HAN J GABR M A | 2002 | Journal of Geotechnical and Geoenvironmental Engineering ASCE2002，128，1： | 1 |
| 12 | A numerical study of load transfer mechanisms in geosynthetic reinforced and pile supported embankments over soft soil显示文摘 | HAN J GABR M A | 2002 | Journal of Geotechnieal and Geoenvironmental Engineering2002，128，1： | 1 |
| 13 | Numerical Analysis of Geosynthetic-reinforced and Pile-supported Earth Platforms over Soft Soil显示文摘 | Han J Gabr M A | 2002 | Journal of Geotechnical and Geoenvironmental Engineering2002，128，1： | 1 |
| 14 | Numerical analysis of geosyntheticreinforced and pile-supported earth platforms over soft soil显示文摘 | Han J Gabr M A | 2002 | Journal of Geotechnical and Geoenviornmental Engineering2002，128，1： | 1 |
| 15 | Buckling of piles with general power distribution of lateral subgrade reaction显示文摘 | Gabr M A Wang J J Zhao M H | 1997 | Journal of Geotechnical and Geoenvironmental Engineering1997，，2： | 1 |
| 16 | Success of la- ser endoureterotomy of ureteral strictures associated with ureteral stones is related to stone impaction显示文摘 | Gdor Y Gabr A H Faerber G J | 2008 | J Endourol2008，22，11： | 1 |
| 17 | Canine ureteral replacement with long acellular matrix tube:is it clinically applicable显示文摘 | Osman Y Shokeir A Gabr M | | 0，，03： | 1 |
| 18 | Numerical analysis of geosynthetic-reinforced and pile-supported earth platforms over soft soil显示文摘 | Han J Asce M Gabr M A | 2002 | Journal of Geotechnical and Geoenvironment Engineering2002，128，1： | 1 |
| 19 | Numerical analysis of geosynthetics-reinforced and pile-supported earth platforms over soft soil显示文摘 | HAN J GABR M A | 2002 | Journal of Geotechnical and Geoenvironmental Engineering ASCE2002，128，1： | 1 |
| 20 | Numerical analysis of geosyntheticreinforced and pile-supported earth platforms over soft soil显示文摘 | J Han M A Gabr | 2001 | Journal of Geotechnical and Geoenvironmental Engineering2001，128，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员