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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Twenty-five years of research on the effects of exercise training in breast cancer survivors:A systematic review of the literature显示文摘AIM:To investigate the role of exercise training the past 25 years on major physiological-psychological outcomes studied thus far in this patient population.METHODS:Pub Med, Medline Plus, the Cochrane Library, Web of Science, SportD iscus, Embase, Scorpus, and Google Scholar were searched from September to November 2013 to identify exercise training studies that used objective measurements of fitness and/or patient reported outcomes assessed pre and post-exercise training with statistical analyses performed in at least one of the following outcome measurements:Cardiorespiratory function, body composition, muscular strength, fatigue, depression, and overall quality of life. Five reviewers independently identified the studies that met the criteria for the review and discrepancies were resolved by consensus among all authors.RESULTS:Fifty-one studies were included in this review with 5 from the period between 1989-1999, 11 from 2000-2006, and 35 from 2007-2013. The evolution of study designs changed from aerobic only exercise training interventions(1989-1999), to a combination of aerobic and resistance training(2000-2006), to studies including an arm of resistance training or examining the effects of resistance training as the main mode of exercise(2007-2013). Overall, the benefits of exercise showed improvements in cardiorespiratory function, body composition, strength, and patient reported outcomes including fatigue, depression, and quality of life.CONCLUSION:Exercise training appears to be safe for most breast cancer patients and improvements in physiological, psychological, and functional parameters can be attained with regular participation in moderate intensity exercise. | Claudio L Battaglini Robert C Mills Brett L Phillips Jordan T Lee Christina E Story Marcelo GB Nascimento Anthony Carl Hackney | 2014 | World Journal of Clinical Oncology2014，5，2： | 3 |
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| 9 | Cadmium-a rnetallohor-mone?显示文摘 | Byme C Divekar SD Storchan GB | 2009 | Toxicol Appl Pharmacol2009，238，3： | 1 |
| 10 | In vivo and in vitroolarian carcinoma growth inhibition by a phosphatidylinositol 3 kinase inhibitor(LY294002)显示文摘 | Hu L Zaloudek C Mills GB | 2000 | Clin Cancer Res2000，6，3： | 1 |
| 11 | Mechanism of action of calcium and hydroxyl ions of calcium hydroxide on tissue and bacteria显示文摘 | Estrela C Sydney GB Bammann LL | 1995 | Braz Dent J1995，6，： | 1 |
| 12 | A model system to study antimicrobial strategies in endodontic biofilms显示文摘 | Estrela C Sydney GB Figueiredo JA | 2009 | J Appl Oral Sci2009，17，2： | 1 |
| 13 | An effect of the PAI-1 4G/5G polymorphism on cholesterol levels may explain conflicting associations with myocardial infarction and stroke显示文摘 | Boncoraglio GB Bodini A Brambilla C | 2006 | Cerebrovasc Dis2006，22，23： | 1 |
| 14 | Augmentation of J waves and electrical storms in patients with early repolarization显示文摘 | Nam GB Kim YH Antzelevitch C | 2008 | N EnglJ Med2008，358，19： | 1 |
| 15 | Variability in extent of platelet function inhibition after administration of optimal dose of glycoprotein Ⅱ b/Ⅲ a receptor Mockers in patients undergoning a high-risk percutaneous coronary intervention显示文摘 | Danzi GB Capuano C Sesana M | 2006 | Am J Cardiol2006，97，4： | 1 |
| 16 | Insulin resistance in cognitive impairment:the InCHIANTI study显示文摘 | Geroldi C Frisoni GB Paolisso G | 2005 | Arch Neurol2005，62，7： | 1 |
| 17 | The modulations of NCAM polysialylation state that follow transient global ischemia are brief on neurons but enduring on glia显示文摘 | Fox GB Kjoller C Murphy K J | 2001 | Neuropathol Exp Neurol2001，60，2： | 1 |
| 18 | Gastrointestinal stromal turnout treated with neoadjuvant imatinib显示文摘 | Loughrey MB Mitchell C Mann GB | 2005 | J Clin Pathol2005，58，7： | 1 |
| 19 | Cochlear implanted children present vocal parameters within normal standards显示文摘 | LOURDES B R DE S MARIA C B ALCIONE GB | 2012 | Int J Pediatric Otolaryngol2012，76，： | 1 |
| 20 | Impact of viability and scar tissue on response to cardiac resynchronization therapy in ischaemic heart failure patients 显示文摘 | Ypenburg C Schalij M J Bleeker GB | 2007 | Eur Heart J2007，28，1： | 1 |
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