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| 1 | Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells显示文摘Acute myeloid leukemia(AML)is a serious disease.The 5-year survival rates remain frustratingly low(65%for children and 26%for adults).Resistance to frontline chemotherapy(usually cytarabine)often develops;therefore a new treatment modality is needed.Bcl-2 family proteins play an important role in balancing cell survival and apoptosis.The antiapoptotic Bcl-2 family proteins have been found to be dysregulated in AML.ABT-199,a BH3 mimetic,was developed to target antiapoptotic protein Bcl-2.Although ABT-199 has demonstrated promising results,resistance occurs.Previous studies in AML show that ABT-199 alone decreases the association of proapoptotic protein Bim with Bcl-2,but this is compensated by increased association of Bim with prosurvival protein Mcl-1,stabilizing Mcl-1,resulting in resistance to ABT-199.In this study,we investigated the antileukemic activity of the Mcl-1-selective inhibitor A-1210477 in combination with ABT-199 in AML cells.We found that A-1210477 synergistically induced apoptosis with ABT-199 in AML cell lines and primary patient samples.The synergistic induction of apoptosis was decreased upon Bak,Bax and Bim knockdown.While A-1210477 treatment alone also increased Mcl-1 protein levels,combination with ABT-199 reduced binding of Bim to Mcl-1.Our results demonstrate that sequestration of Bim by Mcl-1,a mechanism of ABT-199 resistance,can be abrogated by combined treatment with the Mcl-1 inhibitor A-1201477. | Daniel A Luedtke Xiaojia Niu Yihang Pan Jianyun Zhao Shuang Liu Holly Edwards Kang Chen Hai Lin Jeffrey W Taub Yubin Ge | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 11 |
| 2 | Determinants of weaknesses in internal control over financial reporting显示文摘 | Jeffrey Doyle Weili Ge Sarah McVay | 2006 | Journal of Accounting and Economics2006，，1： | 9 |
| 3 | Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia显示文摘Venetoclax,an FDA-approved Bcl-2 selective inhibitor for the treatment of chronic lymphocytic leukemia and acute myeloid leukemia(AML),is tolerated well in elderly patients with AML and has good overall response rates;however,resistance remains a concern.In this study,we show that targeting CDK9 with voruciclib in combination with venetoclax results in synergistic antileukemic activity against AML cell lines and primary patient samples.CDK9 inhibition enhances venetoclax activity through downregulation of Mcl-1 and c-Myc.However,downregulation of Mcl-1 is transient,which necessitates an intermittent treatment schedule to allow for repeated downregulation of Mcl-1.Accordingly,an every other day schedule of the CDK9 inhibitor is effective in vitro and in vivo in enhancing the efficacy of venetoclax.Our preclinical data provide a rationale for an intermittent drug administration schedule for the clinical evaluation of the combination treatment for AML. | Daniel A.Luedtke Yongwei Su Jun Ma Xinyu Li Steven ABuck Holly Edwards Lisa Polin Juiwanna Kushner Sijana HDzinic Kathryn White Hai Lin Jeffrey WTaub Yubin Ge | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 4 | The first data release(DR1) of the LAMOST regular survey显示文摘The Large sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST) general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio(SNR) ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters: late A,FGK-type stars with high quality spectra(1 061 918 entries), A-type stars(100 073 entries), and M-type stars(121 522 entries). This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided. | A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai Deng Xiao-Wei Liu Yi-Peng Jing Gang Wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Li Chen Xue-Lei Chen Xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng Jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-Liang He Jin-Liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua Jiang Xiang Jiang Zhi-Bo Jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li Guang-Wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li Yin-Bi Li Ye-Ping Li Yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao Yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang Guo-Min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-Ling Wang Jian-Ping Wang Jun-Xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-Qing Wang Xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang Hai-Feng Yang Hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang Jian-Nan Zhang Li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo | 2015 | Research in Astronomy and Astrophysics2015，15，8： | 2 |
| 5 | Determinants of weaknesses in internal control over financial reporting显示文摘 | Jeffrey Doyle Weili Ge Sarah McVay | 2006 | Journal of Accounting and Economics2006，，1： | 2 |
| 6 | Transcatheter Aortic-Valve Replacement with a Self-Expanding Prosthesis显示文摘 | David H. Adams Jeffrey J. Popma Michael J. Reardon Steven J. Yakubov Joseph S. Coselli G. Michael Deeb Thomas G. Gleason Maurice Buchbinder James Hermiller Neal S. Kleiman Stan Chetcuti John Heiser William Merhi George Zorn Peter Tadros Newell Robinson Ge | 2014 | The New England Journal of Medicine2014，，19： | 1 |
| 7 | Determinants of weaknesses in internal control over financial reporting显示文摘 | Jeffrey Doyle Weili Ge Sarah McVay | 2006 | Journal of Accounting and Economics2006，，1： | 1 |
| 8 | Accruals Quality and Internal Control over Financial Reporting 显示文摘 | Jeffrey T Doyle Weili Ge Sarah McVay | 2007 | The Accounting Review2007，，82： | 1 |
| 9 | Determinants of Weaknesses in Internal Control over Financial Reporting显示文摘 | Jeffrey Doyle Weili Ge Sarah Mcvay | | 0，，： | 1 |
| 10 | Accruals quality and internal control over financial reporting显示文摘 | Jeffrey T.Doyle Weili Ge Sarah McVay | | 0，，10： | 1 |
| 11 | Accruals quality and internal control over/inancial reporting显示文摘 | JEFFREY T D GE Weili SARAH M V | 2007 | The Accounting Review2007，82，5： | 1 |
| 12 | Determinants of Weaknesses in Internal Control over Financial Reporting显示文摘 | Jeffrey Doyle Weili Ge Sarah Mc-Vay | 2006 | SSRN Working Paper2006，，： | 1 |
| 13 | Determinants of Weaknesses in Internal Control over Financial Reporting显示文摘 | Jeffrey Doyle Weili Ge Sarah Mcvay | 2007 | Journal of Accounting and Economics2007，，： | 1 |
| 14 | Type synthesis of parallel mechanisms having the second class GF sets and two dimensional rotations显示文摘 | Feng Gao Jialun Yang Qiaode Jeffrey Ge | 2011 | Journal of Mechanisms and Robotics2011，3，1： | 1 |
| 15 | Integrating diverse methods to understand climate–land interactions in East Africa显示文摘 | Jennifer M. Olson Gopal Alagarswamy Jeffrey A. Andresen David J. Campbell Amelie Y. Davis Jianjun Ge Marianne Huebner Brent M. Lofgren David P. Lusch Nathan J. Moore Bryan C. Pijanowski Jiaguo Qi Philip K. Thornton Nathan M. Torbick Jing Wang | 2007 | Geoforum2007，，： | 1 |
| 16 | Determinants of Weaknesses in Internal Control Over Financial Reporting 显示文摘 | Jeffrey Doyle Weili Ge Sarah McVay | 2007 | Journal of Accounting & Economics2007，44，12： | 1 |
| 17 | Determinants of Weaknesses in Internal Control over Financial Reporting 显示文摘 | Jeffrey Doyle Weili Ge and Sarah McVay | 2007 | Journal of Accounting and Economics2007，44，： | 1 |
| 18 | Determinants of weaknesses in internal control over financial reporting显示文摘 | Jeffrey Doyle Weili Ge Sarah McVay | | 0，，44： | 1 |
| 19 | Accruals Quality and Internal Control over Financial Reporting 显示文摘 | Jeffrey T Doyle Weili Ge Sarah McVay | 2007 | The Accounting Review2007，82，5： | 1 |
| 20 | Accruals quality and internal control over financial reporting显示文摘 | Jeffrey T D Ge Weili | 2007 | The Accounting Review2007，82，： | 1 |
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