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| 1 | Less common etiologies of exocrine pancreatic insufficiency显示文摘Exocrine pancreatic insufficiency(EPI), an important cause of maldigestion and malabsorption, results from primary pancreatic diseases or secondarily impaired exocrine pancreatic function. Besides cystic fibrosis and chronic pancreatitis, the most common etiologies of EPI, other causes of EPI include unresectable pancreatic cancer, metabolic diseases(diabetes); impaired hormonal stimulation of exocrine pancreatic secretion by cholecystokinin(CCK); celiac or inflammatory bowel disease(IBD) due to loss of intestinal brush border proteins; and gastrointestinal surgery(asynchrony between motor and secretory functions, impaired enteropancreatic feedback, and inadequate mixing of pancreatic secretions with food). This paper reviews such conditions that have less straightforward associations with EPI and examines the role of pancreatic enzyme replacement therapy(PERT). Relevant literature was identified by database searches. Most patients with inoperable pancreatic cancer develop EPI(66%-92%). EPI occurs in patients with type 1(26%-57%) or type 2 diabetes(20%-36%) and is typically mild to moderate; by definition, all patients with type 3 c(pancreatogenic) diabetes have EPI. EPI occurs in untreated celiac disease(4%-80%), but typically resolves on a gluten-free diet. EPI manifests in patients with IBD(14%-74%) and up to 100% of gastrointestinal surgery patients(47%-100%; dependent on surgical site). With the paucity of published studies on PERT use for these conditions, recommendations for or against PERT use remain ambiguous. The authors conclude that there is an urgent need to conduct robust clinical studies to understand the validity and nature of associations between EPI and medical conditions beyond those with proven mechanisms, and examine the potential role for PERT. | Vikesh K Singh Mark E Haupt David E Geller Jerry A Hall Pedro M Quintana Diez | 2017 | World Journal of Gastroenterology2017，23，39： | 5 |
| 2 | A randomized double-blind comparison of epidural sufentanil versus intravenous sufentanil or epidural fentanyl analgesia after major abdominal surgery显示文摘 | Geller E Chrubasik J Graf R | 1993 | Anesth Analg1993，76，： | 1 |
| 3 | Ten principles for achieving a total safety c ulture显示文摘 | Geller S E | 1994 | Professional Safety1994，39，3： | 1 |
| 4 | A randomized double blind comparison of epidural sufentanil versus intravenous sufentanil orepidural fentanly analgesia after major abdominal surgery显示文摘 | Geller E Chrubasik J Gaf R | 1993 | AnesthAnalg1993，76，6： | 1 |
| 5 | Drape estimation vs v-isualassessment for estimating postpartum hemorrhage显示文摘 | Patel A Goudar S S Geller S E | 2006 | Int JGynaecol Obstet2006，93，3： | 1 |
| 6 | Respiratory Care and Cystic Fibrosis显示文摘 | David E Geller MD Bruce K | 2009 | Respir Care2009，54，6： | 1 |
| 7 | Hip fractures in patients with Parkinson's syndrome显示文摘 | Eventov I Moreno M Geller E | 1983 | J Trauma1983，23，： | 1 |
| 8 | Morbidity and mortality in pregnancy: Laying the groundwork for safe motherhood 显示文摘 | Geller S E Cox S M Callaghan W M | 2006 | Women'' s Health Issues2006，16，4： | 1 |
| 9 | Impact of heart failure on the incidence of contrast-induced nephropathy in patients with chronic kidney disease显示文摘 | Rosenstock J L Gilles E Geller A B | 2010 | Int Urol Nephrol2010，42，4： | 1 |
| 10 | Short-term outcomes of robotic sacrocolpopexy compared with abdominal sacrocolpopexy 显示文摘 | Geller E J Siddiqui NY Wu JM | 2008 | Obstet Gyneco12008，112，6： | 1 |
| 11 | Botanical and dietary supplements for menopausal symptoms: what works, what does not显示文摘 | Geller S E Studee L | 2005 | J Women'' s Health : Larchmt2005，14，： | 1 |
| 12 | A safety self-management intervention for mining operations显示文摘 | Hickman Jeffrey S Geller E S | 2003 | Journal of SafetyResearch2003，34，3： | 1 |
| 13 | Construct Definition Using Cognitively Based Evidence: A Framework for Practice 显示文摘 | Ketterlin - Geller L R Yovanoff P Jung E | 2013 | Educational Assessment2013，18，2： | 1 |
| 14 | A randomized double-blind comparison of epidural sufentanil versus intravenous sufentanil or epidural fentanyl analgesia after major abdominal surgery显示文摘 | Geller E Chrubasik J Graf R | 1993 | Anesth1993，76，12： | 1 |
| 15 | Navigating the road to autonomous orbital rendezvous 显示文摘 | WOFFINDEN D E GELLER D K | 2007 | Journal of Space- craft and Rockets2007，44，4： | 1 |
| 16 | The effect of flumazenil on the process of recovery from halothane anaesthesia显示文摘 | Geller E W einbrum A Schiff B et a1 | 1988 | Eur J Armesthesiol1988，53，： | 1 |
| 17 | Maize HapMap2 identifies extant variation from a genome in flux 显示文摘 | Jer-Ming Chia Chi Song Peter J Bradbury Denise Cos- tich Natalia de Leon John Doebley Robert J Elshire Brandon Gaut Laura Geller Jeffrey C Glaubitz Michael Gore Kate E Guill Jim Holland Matthew B Hufford Jinsheng Lai Meng Li Xin Liu Yanli Lu Richard Mc- Combie Rebecca Nelson Jesse Poland Boddupalli M Prasanna Tanja Pyhajarvi Tingzhao Rong Rajandeep S Sekhon Qi Sun Maud I Tenaillon Feng Tian Jun Wang Xun Xu Zhiwu Zhang Shawn M Kaeppler Jef- frey Ross-lbarra Michael D McMullen Edward S Buck- ler Gengyun Zhang Yunbi Xu Doreen Ware | 2012 | Nat Genet2012，，44： | 1 |
| 18 | The I-neb adaptive aerosol delivery system enhances delivery of alphal-antitrypsin with controlled inhalation显示文摘 | Geller D E Kesser K C | 2010 | J Aerosol Med Pulm Drug Deliv2010，23，1： | 1 |
| 19 | Flumazenil improves cognitive and neuromotor,emergence and attenuates shivering after halothane enflurne-and isflurane-based anesthesia显示文摘 | Weinbroum AA Geller E | | 0，，10： | 1 |
| 20 | Peptide-conjugated phosphorodiamidate morpholino oligomers: a new strategy for tackling antibiotic resistance显示文摘 | Geller B L Greenberg D E | 2014 | Ther Deliv2014，5，3： | 1 |
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