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| 1 | Influence of vitamin D on liver fibrosis in chronic hepatitis C: A systematic review and meta-analysis of the pooled clinical trials data显示文摘AIM To investigate the relationship between vitamin D and liver fibrosis in hepatitis C-monoinfected or hepatitis C virus(HCV)-human immunodeficiency virus(HIV) coinfected patients. METHODS Pertinent studies were located by a library literature search in PubM ed/Embase/Cochrane/Scopus/LILACS by two individual reviewers. Inclusion criteria:(1) studies with patients with HCV or co-infected HCV/HIV;(2) studies with patients ≥ 18 years old;(3) studies that evaluated liver fibrosis stage, only based on liver biopsy; and(4) studies that reported serum or plasma 25(OH)D levels. Studies that included pediatric patients, other etiologies of liver disease, or did not use liver biopsy for fibrosis evaluation, or studies with inadequate data were excluded. Estimated measures of association reported in the literature, as well as corresponding measures of uncertainty, were recorded and corresponding odds ratios with 95%CI were included in a meta-analysis. RESULTS The pooled data of this systematic review showed that 9 of the 12 studies correlated advanced liver disease defined as a Metavir value of F3/4 with 25(OH) D level insufficiency. The meta-analysis indicated a significant association across studies.CONCLUSION Low vitamin D status is common in chronic Hepatitis C patients and is associated with advanced liver fibrosis. | Alia S Dadabhai Behnam Saberi Katie Lobner Russell T Shinohara Gerard E Mullin | 2017 | World Journal of Hepatology2017，9，5： | 6 |
| 2 | Vitamin D levels do not predict the stage of hepatic fibrosis in patients with non-alcoholic fatty liver disease: A PRISMA compliant systematic review and meta-analysis of pooled data显示文摘AIM To investigate the relationship between 25-hydroxyvitamin D [25(OH)D] levels and fibrosis stage in patients with non-alcoholic fatty liver disease(NAFLD).METHODS Two individual reviewers identified relevant studies using the Pub Med, EMBASE, Cochrane, and Scopus databases. Inclusion criteria were as follows:(1) Studies that evaluated adults with NAFLD and serum or plasma 25(OH)D levels; and(2) assessed fibrosis stage using liver biopsy. A rigorous analysis yielded six articles as having sufficient data to employ in evaluating the association of serum vitamin D levels in patients with NAFLD based on their liver fibrosis stage by histopathological analysis. The lead investigators of each of the six studies were contacted and the data were collected. To meta-analyze vitamin D levels in F0-F2 vs F3-F4 fibrosis, a random-effects meta-analysis fit using restricted maximum likelihood was applied. To examine trends across each stage of fibrosis with respect to vitamin D levels, a meta-regression was performed. P < 0.05 was considered statistically significant. RESULTS A total of 937 subjects from six studies were included in the final analysis to evaluate the association of serum vitamin D levels in patients with NAFLD based on their liver fibrosis stage by histopathological analysis. The lead investigators of each of the six studies were contacted and the data were collected. First, the investigators performed a meta-analysis to compare serum vitamin D levels in patients with NAFLD with stage F0-F2 compared to F3-F4, which did not show significance [meta-estimate of the pooled mean difference =-0.86, P = 0.08(-4.17, 2.46)]. A metaregression evaluation of serum vitamin 25(OH)D levels across the individual stages(F0-F4) of fibrosis did not show an association for the six included studies.CONCLUSION Low vitamin D status is not associated with higher stages of liver fibrosis in patients with NAFLD. | Behnam Saberi Alia S Dadabhai Julie Nanavati Lin Wang Russell T Shinohara Gerard E Mullin | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 3 | Coronary physiology assessment in the catheterization laboratory显示文摘Physicians cannot rely solely on the angiographic appearance of epicardial coronary artery stenosis when evaluating patients with myocardial ischemia. Instead, sound knowledge of coronary vascular physiology and of the methods currently available for its characterization can improve the diagnostic and prognostic accuracy of invasive assessment of the coronary circulation, and help improve clinical decision-making. In this article we summarize the current methods available for a thorough assessment of coronary physiology. | Felipe Díez-delhoyo Enrique Gutiérrez-Ibanes Gerard Loughlin Ricardo Sanz-Ruiz María Eugenia Vázquez-álvarez Fernando Sarnago-Cebada Rocío Angulo-Llanos Ana Casado-Plasencia Jaime Elízaga Francisco Fernández Avilés Diáz | 2015 | World Journal of Cardiology2015，7，9： | 2 |
| 4 | CotCo2:a cotton growth simulation model for global change显示文摘 | Gerard W W Jeffrey S A Kimball B A | 1994 | Agriculture and Forest Meteorology1994，70，： | 1 |
| 5 | Competition for limiting amounts of oxygen between nitrosomanas europaea and nitrobacteria winogradskyi grown in mixed continuous cultures显示文摘 | Laanbroek H J Gerards S | 1993 | Arch Microbiology1993，，159： | 1 |
| 6 | Comparison of two neoadjuvant chemoradiotherapyregimens for locally advanced rectal cancer: results of thephase III trial ACCORD 12/0405-Prodige 2显示文摘 | GERARD JP AZRIA D GOURGOU-BOURGADE S etal | 2010 | J Clin On-col2010，28，10： | 1 |
| 7 | Neuroanatomical correlates of visually evoked sexual arousal in human males 显示文摘 | Stoleru S Gregoire MC Gerard D | 1999 | Arch Sex Behav1999，28，： | 1 |
| 8 | Competition for limiting amounts of oxygen between nitrosomanas European and nitmbacteria wingogradsbyi grown in mixed continuous cultures 显示文摘 | Lannbroek H J Gerards S | 1993 | Arch Microbiology1993，159，： | 1 |
| 9 | Molecular dynamics simulation of or- ganic-inorganic copolymers based on methacryl-POSS and methyl methacrylate 显示文摘 | Bizet S Galy J Gerard J-F | 2006 | Polymer2006，47，24： | 1 |
| 10 | Phenolic compounds and antioxidant capacity of georgia-grown blueberries and blackberries显示文摘 | SUBRAMANI S CASIMIR C A GERARD K | 2002 | Agricultural Food Chemistry2002，，50： | 1 |
| 11 | Exclusion of unstable cervical spine injury in obtunded patients with blunt trauma:is MR imaging needed when multidetector row CT findings are normal?显示文摘 | Gerard JH Stuart EM Kathirkamanathan S | 2005 | Radiology2005，237，： | 1 |
| 12 | Competition for limiting amounts of oxygen between Nitrosomonas europaea and Nitrobacter winogradskyi grown in mixed continuous cultures显示文摘 | Laanbroek H J Gerards S | 1993 | Archives of Microbiology1993，159，5： | 1 |
| 13 | The influence of cigarette smoking on human spem quality and DNA fragmentation显示文摘 | SEPANIAK S FORGES T GERARD H | 2006 | Toxicology2006，223，12： | 1 |
| 14 | Phylogeny-function analysis of (meta)genomic libraries: screening for expression of ribosomal RNA genes by large-insert library fluorescent in situ hybridisation (LIL-FISH) 显示文摘 | Leveau J H J Gerards S de Boer W | 2004 | Environ Microbiol2004，6，9： | 1 |
| 15 | Competition for limiting amounts of oxygen between Nitrosomonas europaea and Nitrobacter winogradskyi grown in mixed continuous cultures 显示文摘 | Laanbroek H J Gerards S | 1993 | Archives of Microbiology1993，159，6： | 1 |
| 16 | Structure-property relationships in or- ganic-inorganic nanomaterials based on methacryl-POSS and dime- thacrylate networks 显示文摘 | Bizet S Galy J Gerard J-F | 2006 | Macromolecules2006，39，7： | 1 |
| 17 | A Description of Clinical Nurse Specialist Programs in the United States显示文摘 | Walker J Gerard P S Bayley E W | 2003 | Clin Nurse Spec2003，17，1： | 1 |
| 18 | Competition for limiting amounts of oxygen between Nitrosomonas europaea and Nitrobacter winogradskyi grown in mixed continuous cultures 显示文摘 | Laanbroek H J Gerards S | 1993 | Arch Microbiol1993，159，5： | 1 |
| 19 | Dynamic response of guyed masts显示文摘 | YOHANNA M F W and GERARD R M | 1998 | Engineering Structure1998，20，12： | 1 |
| 20 | Confirmation of food origin claims by fourier transform infrared spectroscopy and chemometrics: extra virgin olive oil from Liguria 显示文摘 | Hennessy S Gerard D and Colm P O | 2009 | Journal of Agricultural and Food Chemistry2009，57，： | 1 |
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