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| 1 | Transarterial radioembolization for hepatocellular carcinoma:An update and perspectives显示文摘In the last decade trans-arterial radioembolization has given promising results in the treatment of patients with intermediate or advanced stage hepatocellular carcinoma(HCC),both in terms of disease control and tolerability profile.This technique consists of the selective intra-arterial administration of microspheres loaded with a radioactive compound(usually Yttrium90),and exerts its therapeutic effect through the radiation carried by these microspheres.A careful and meticulous selection of patients is crucial before performing the radioembolization to correctly perform the procedure and reduce the incidence of complications.Radioembolization is a technically complex and expensive technique,which has only recently entered clinical practice and is supported by scant results from phase Ⅲ clinical trials.Nevertheless,it may represent a valid alternative to transarterial chemoembolization(TACE) in the treatment of intermediate-stage HCC patients,as shown by a comparative retrospective assessment that reported a longer time to progression,but not of overall survival,and a more favorable safety profile for radioembolization.In addition,this treatment has reported a higher percentage of tumor shrinkage,if compared to TACE,for pre-transplant downsizing and it represents a promising therapeutic option in patients with large extent of disease and insufficient residual liver volume who are not immediately eligible for surgery.Radioembolization might also be a suitable companion to sorafenib in advanced HCC or it can be used as a potential alternative to this treatment in patients who are not responding or do not tolerate sorafenib. | Rodolfo Sacco Valeria Mismas Sara Marceglia Antonio Romano Luca Giacomelli Marco Bertini Graziana Federici Salvatore Metrangolo Giuseppe Parisi Emanuele Tumino Giampaolo Bresci Ambra Corti Manuel Tredici Michele Piccinno Luigi Giorgi Carlo Bartolozzi Irene Bargellini | 2015 | World Journal of Gastroenterology2015，21，21： | 4 |
| 2 | Assessment of clinical and radiological response to sorafenib in hepatocellular carcinoma patients显示文摘Sorafenib is an effective anti-angiogenic treatment forhepatocellular carcinoma(HCC). The assessment of tumor progression in patients treated with sorafenib is crucial to help identify potentially-resistant patients,avoiding unnecessary toxicities. Traditional methods to assess tumor progression are based on variations in tumor size and provide unreliable results in patients treated with sorafenib. New methods to assess tumor progression such as the modified Response Evaluation Criteria in Solid Tumors or European Association for the Study of Liver criteria are based on imaging to measure the vascularization and tumor volume(viable or necrotic). These however fail especially when the tumor response results in irregular development of necrotic tissue. Newer assessment techniques focus on the evaluation of tumor volume,density or perfusion. Perfusion computed tomography and Dynamic ContrastEnhanced-UltraS ound can measure the vascularization of HCC lesions and help predict tumor response to antiangiogenic therapies. Mean Transit Time is a possible predictive biomarker to measure tumor response. Volumetric techniques are reliable,reproducible and time-efficient and can help measure minimal changes in viable tumor or necrotic tissue,allowing the prompt identification of non-responders. Volume ratio may be a reproducible biomarker for tumor response. Larger trials are needed to confirm the use of these techniques in the prediction of response to sorafenib. | Rodolfo Sacco Valeria Mismas Antonio Romano Marco Bertini Michele Bertoni Graziana Federici Salvatore Metrangolo Giuseppe Parisi Emanuele Tumino Giampaolo Bresci Luca Giacomelli Sara Marceglia Irene Bargellini | 2015 | World Journal of Hepatology2015，7，1： | 2 |
| 3 | 往复压缩机气阀技术显示文摘 | Francesca Cozzani Marco Pucci Enzo Giacomelli | 2006 | 通用机械2006，，11： | 2 |
| 4 | Dietary soy modulation of biochemical parameters in DMBA -induced mammary tumors 显示文摘 | Gallo D Ferrandina G Giacomelli S | 2002 | Cancer Lett2002，186，1： | 1 |
| 5 | Arabidopsis thaliana defi- cient in two chloroplast ascorbate pemxidases shows accelerated light-in, dueed necrosis when levels of cellular aseod)ate are low 显示文摘 | GIACOMELLI L MASI A RIPOLL D R | 2007 | Plant Mol Biol2007，65，5： | 1 |
| 6 | Electrochemical oxidation of quercetin in hydro-alcoholic solution显示文摘 | TIMBOLA A K SOUZA C D D GIACOMELLI C et ak | 2006 | J Braz Chem Soc2006，17，1： | 1 |
| 7 | Silybin and its bioavail- able phospholipid complex (idb 1016) potentiate in vitro and invivo the activity of cisplatin显示文摘 | Giacomelli s Gallo D Appllonio P | 2002 | Life Sci2002，70，12： | 1 |
| 8 | A Facile Approach to the Synthesis of Chiral 2 - Substituted Benzofurans 显示文摘 | Luca L D Giacomelli G Nieddu G | 2007 | J Org Chem2007，72，： | 1 |
| 9 | Advanced neutron diagnostics for JET and ITER fusion experiments at JET显示文摘 | Giacomelli L Hjalmarsson A Sjostrand H | 2005 | Nuclear Fusion2005，45，： | 1 |
| 10 | GM-CSF and pregnancy:evidence of significantly reduced blood concentrations in immunoglobulin treatment显示文摘 | Perricone R De Carolis C Giacomelli R | 2003 | Am J Reprod Immunol2003，50，3： | 1 |
| 11 | Antitumour activity of the silybin-phosphatidylcholine complex,IdB 1016,against human ovarian cancer显示文摘 | Gallo D Giacomelli S Ferlini C Raspaglio G Apollonio P Prislei S Riva A Morazzoni P Bombardelli E Scambia G | | 0，，： | 1 |
| 12 | Dynamic modeling and simulation of greenhouse environments under several scenarios:a web-based application显示文摘 | Fitz Rodríguez Efrén Kubota Chieri Giacomelli Gene A | | 0，，01： | 1 |
| 13 | Gene expression of human T lymphocytes cell cycle:experimental and bioinformatic analysis显示文摘 | Giacomelli L Nicolini C | 2006 | J Cell Biochem2006，22，： | 1 |
| 14 | The interaction between autoimmune diseases and fibromyalgia:risk,disease course and management显示文摘 | Giacomelli C Talarico R Bombardieri S | | 0，，： | 1 |
| 15 | Chemoprevention of DMBA-induced mammary cancer in rats by dietary soy显示文摘 | Giacomelli S Cantelmo F | 2001 | Breast Cancer Res Treat2001，69，2： | 1 |
| 16 | Detection of human papillo-mavirus DNA,p53 and ki67 expression in penile carcinomas显示文摘 | Gentile V Vicini P Giacomelli L | 2006 | Int JImmunopathol Pharmacol2006，19，1： | 1 |
| 17 | New cellulose-supported reagent:A sustainable approach to guanidines显示文摘 | PORCHEDDU A GIACOMELLI G CHIGHINE A | 2004 | Organic Letters2004，6，26： | 1 |
| 18 | Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A(LDH-A)as starvation agents against cancer cells显示文摘 | Granchi C Roy S Giacomelli C | 2011 | J Med Chem2011，54，6： | 1 |
| 19 | Aeroponics:an alternative production system for high-value root crops显示文摘 | Hayden A L Yokelson T N Giacomelli G A | 2004 | Acta Horticulturae2004，629，： | 1 |
| 20 | Problems of operative and non-operative treatment and healing in tibial fractures显示文摘 | Gicquel P Giacomelli MC Basic B | 2005 | Injury2005，，： | 1 |
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