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| 1 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 2 | Space charge behaviors in cable insulation under a direct current‐superimposed pulsed electric field显示文摘When high‐voltage direct current(HVDC)cables are subjected to a direct current(DC)‐superimposed pulsed electric stress,the pulsed voltage applied facilitates electrical tree generation and breakdown;however,the mechanism involved remains unclear.To study the deterioration mechanism of cable insulation under a pulsed electric field,an experi-ment on the dynamic characteristics of space charge under a DC‐superimposed pulsed electric field was conducted.For this experiment,a pulsed time trigger control circuit was developed to accurately measure the change law of the space charge in cross‐linked polyethylene samples at the rising and falling edges of the pulsed electric field.The experimental results showed an unusual change law:the space charge density increases with falling voltage amplitude and decreases with rising voltage amplitude.The sudden change in the electric field breaks the balance of the forces acting on the space charge,leading to injection,extraction and migration.The energy released during these dynamic processes may destroy the microstructure of the insulation material and contributes to the growth of the electrical tree.This study provides an insight on the initiation mechanism of electrical tree in HVDC cables and proposes a strategy to suppress electrical tree initiation. | Dongxin He Tao Zhang Fansong Meng Qingquan Li Wei Wang Hongshun Liu Gilbert Teyssedre | 2021 | High Voltage2021，6，3： | 4 |
| 3 | Insulating materials for realising carbon neutrality:Opportunities,remaining issues and challenges显示文摘The 2050 carbon-neutral vision spawns a novel energy structure revolution,and the construction of the future energy structure is based on equipment innovation.Insulating material,as the core of electrical power equipment and electrified transportation asset,faces unprecedented challenges and opportunities.The goal of carbon neutral and the urgent need for innovation in electric power equipment and electrification assets are first discussed.The engineering challenges constrained by the insulation system in future electric power equipment/devices and electrified transportation assets are investigated.Insulating materials,including intelligent insulating material,high thermal conductivity insulating material,high energy storage density insulating material,extreme environment resistant insulating material,and environmental-friendly insulating material,are cat-egorised with their scientific issues,opportunities and challenges under the goal of carbon neutrality being discussed.In the context of carbon neutrality,not only improves the understanding of the insulation problems from a macro level,that is,electrical power equipment and electrified transportation asset,but also offers opportunities,remaining issues and challenges from the insulating material level.It is hoped that this paper en-visions the challenges regarding design and reliability of insulations in electrical equipment and electric vehicles in the context of policies towards carbon neutrality rules.The authors also hope that this paper can be helpful in future development and research of novel insulating materials,which promote the realisation of the carbon-neutral vision. | Chuanyang Li Yang Yang Guoqiang Xu Yao Zhou Mengshuo Jia Shaolong Zhong Yu Gao Chanyeop Park Qiang Liu Yalin Wang Shakeel Akram Xiaoliang Zeng Yi Li Fangwei Liang Bin Cui Junpeng Fang Lingling Tang Yulin Zeng Xingtao Hu Jiachen Gao Giovanni Mazzanti Jinliang He Jianxiao Wang Davide Fabiani Gilbert Teyssedre Yang Cao Feipeng Wang Yunlong Zi | 2022 | High Voltage2022，7，4： | 4 |
| 4 | Charge vibration behaviour in polyimide under the pulse voltage with different rise and fall times显示文摘High‐voltage electronic equipment is widely used in power systems,which normally operate under the pulse voltage condition.However,compared to DC or AC stress,the electrical insulation suffers a more severe ageing process under a pulse voltage with steep edges and so may cause electrical equipments to fail early.The charge behaviour in polyimide under the pulse voltage with different edge times was investigated in this study.The experimental results show that charges vibrate at the pulse edge,while the amplitude of charge vibration increases with decreasing edge times.Furthermore,the detected vibration signal is strong within the nanosecond edge times,while being negligible in the microsecond range.Notably,the amplitude of charge vibration at the falling edge is larger than that at the rising edge in the presence of the column‐plate electrode.It is believed that the resultant force acting on the charge increases drasti-cally at the pulse edges,leading to the charge movement and the generation of ultra-sonic waves,with the resultant force becoming larger when the edge times decrease.Charge vibration behaviour is harmful to the microstructure of insulation materials,and so it may be concluded that the rise and fall times of the pulse voltage play an important role in insulation failure. | Tao Zhang Dongxin He Junyu Wei Hongshun Liu Qingquan Li Gilbert Teyssedre | 2022 | High Voltage2022，7，1： | 2 |
| 5 | Acute myocardial infarction in pregnancy and the puerperium: A population-based study显示文摘 | Ladner HE Danielson B Gilbert WM | 2005 | Obstet Gynecol2005，105，： | 1 |
| 6 | Acute myocardial infarction in pregnancy and the puerperium:a population-based study显示文摘 | Ladner HE Danielsen B Gilbert WM | 2005 | Obstet Gynecol2005，105，： | 1 |
| 7 | Cocaine induces apoptosis in fetal myocardial ceils through a mitochondria-dependent pathway 显示文摘 | Xiao YH He JL Gilbert RD | 2000 | J Pharmacol Experi Therap2000，292，1： | 1 |
| 8 | Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha显示文摘 | Gilbert L He X Farmer P | 2002 | J Biol Chem2002，277，： | 1 |
| 9 | Expression of the osteoblast differentiation factor Runx2 (Cbfal, AML3, Pebp2alpha A) is inhibited by tumor necrosis factor alpha显示文摘 | Gilbert L He X Rubin J | 2002 | J Biol Chem2002，277，： | 1 |
| 10 | Body image and bladder cancer specific quality of life in patients with ileal conduit and neobladder urinary diversions显示文摘 | HEDGEPETH RC GILBERT SM HE C | 2010 | Urology2010，76，3： | 1 |
| 11 | Expression of the osteoblast differ ntiation factor RUNX2 (Cbfa1 /AML3/Pebp2alpha A) is inhibitedby tumor necrosis factor2alpha 显示文摘 | Gilbert L He X Farmer P | 2002 | Biol Chem2002，277，： | 1 |
| 12 | Body image and bladder cancer specific quality of life in patients with ileal conduit and neobladder urinary diversions显示文摘 | Hedgepeth RC Gilbert SM He C | 2010 | Urology2010，76，3： | 1 |
| 13 | Evolution of the Regulators of G-Protein Signaling Multigene Family in Mouse and Human显示文摘 | David A. Sierra Debra J. Gilbert Deborah Householder Nick V. Grishin Kan Yu Pallavi Ukidwe Sheryll A. Barker Wei He Theodore G. Wensel Glen Otero Greg Brown Neal G. Copeland Nancy A. Jenkins Thomas M. Wilkie | 2002 | Genomics2002，，2： | 1 |
| 14 | Expression of the osteoblast differentiation factor RUNX2 (Cbfal/AML3/ Pebp2e A) is in hibited by tumor necrosis factorα 显示文摘 | Gilbert L He X Farmer P | 2002 | J Biol Chem2002，277，4： | 1 |
| 15 | Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp 2alpha A) is inhibited by tumor necrosis factor alpha显示文摘 | Gilbert L He X Farmer P | 2002 | J Biol Chem2002，277，4： | 1 |
| 16 | Body image and bladder cancer specific quality of life in patients with ileal conduit and neobladder urinary diversions显示文摘 | HEDGEPETH R C GILBERT S M HE C | | 0，，： | 1 |
| 17 | Transcriptional regulation of the Osterix (Osx,Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NFκBpathways显示文摘 | LU X GILBERT L HE X | 2006 | J Biol Chem2006，281，10： | 1 |
| 18 | Transcriptional regulation of the osterix(OSX,Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NF kappa B pathways显示文摘 | Lu X Gilbert L He X | | 0，，10： | 1 |
| 19 | Body image and bladder cancer specific quality of life in patients with ileal conduit and neobladder urinary diversions 显示文摘 | sHedgepeth RC Gilbert SM He C | 2010 | Urology2010，76，3： | 1 |
| 20 | Inhibition of osteoblast differentiation by tumor necrosis factor-alpha显示文摘 | Gilbert L He X Farmer V | 2000 | J Endocrinology2000，141，11： | 1 |
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