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58篇 您的检索式:作者名="GOH HS"
    题名 作者 年代 出处 被引量
1p53 cDNA突变和突变型p53蛋白表达与大肠癌预后的关系显示文摘目的 探讨p53基因cDNA突变和突变型p53基因蛋白表达与大肠腺癌预后的关系。方法 RT-PCR-SSCP检测大肠腺癌组织p53基因cDNA突变,PAb240单抗免疫组化检测大肠腺癌组织突变型p53基因蛋白表达,比较两者与大肠腺癌预后的关系。结果 100例大肠腺癌中,p53基因cDNA突变51例(51%),突变型p53基因蛋白高表达76例(76%),两者同步阳性49例;p53基因cDNA突变与突变型p53基因蛋白高表达相关,有显著统计学差异(P<0.01);与Dukes分期无关(P>0.05)。从Kaplan-Meier 生存曲线和log-rank 分析结果看,突变型p53基因蛋白高表达与大肠腺癌预后无显著统计学差异(P=0.72);p53基因cDNA突变与大肠腺癌预后有关,统计学差异明显 (P=0.03)。结论 p53基因cDNA突变与突变型p53基因蛋白高表达密切相关。高频率p53基因cDNA突变直接反映大肠腺癌预后差。突变型p53基因高表达则可能受多因素影响,不能直接反映大肠腺癌预后。季晨阳 季 丹 DR Smith HS Goh 2000第一军医大学学报2000,20,5:2
2Abnormal expression of the p53 tumour suppressor gene in the conjunetiva of patients with pterygium显示文摘Tan DT Lim AS Goh HS 1997Am J Ophthalmol1997,123,:1
3Abnormal expression of the P53 tumor suppressor gene in the conjunctiva of patients with pterygiom 显示文摘Tan DT Lim AS Goh HS et at 1997Am J Ophthalmol1997,123,3:1
4A rare case of' giant' right-sided retroperitoneal bronchogenic cyst显示文摘Goh BK Chan HS Wong WK 2004Dig Dis Sci2004,49,:1
5Prognostic significance of p53 overexpression and mutation in colorectal adenocarcinomas显示文摘Smith DR Ji CY Goh HS 1996Br J Cancer1996,74,:1
6e - mye Oneogene expression in- colorectal cancer: its use in prognosis and role in coloreetal carcino- genesis 显示文摘Goh HS Soong TW Lee YS 1990Ann Aead Med Singapore1990,19,:1
7Abnormal expression of the p53 tumour suppressor gene in the conjunctiva of patients with pterygium显示文摘Tan DT Lim AS Goh HS 1997Am J Ophr thalmol1997,123,:1
8Abnormal expression of the p53 tumor suppressor gene in the conjunctiva of patients with pterygium显示文摘Tan DT Lim AS Goh HS 1997Arch Ophthalmology1997,115,10:1
9lntra - abdominal and retropefitoneal lymphangiomas in pediatric and adult patients 显示文摘Goh BK Tan YM Ong HS 2005World J Surg2005,29,:1
10Over expression of the c~myc protcroncogene in colorectal carcinoma 显示文摘Smith DR Myint T Goh HS 1993Br J Cancer1993,68,2:1
11Gastrointestinal stromal tumor involving the second and third portion of the duodenum: treatment by partial duodenectomy and Roux-en-Y duodenojejunostomy显示文摘Goh BK Chow PK Ong HS et at 2005J Surg Oncol2005,91,4:1
12Hydrogen sulfide inhibits plasma renin activity显示文摘Lu M Liu YH Goh HS 2010J Am Soc Nephrol2010,21,6:1
13Intra-abdominal and retroperitoneal lymphangiomas in pediatric and adult patients显示文摘Goh BK Tan YM Ong HS 0,,07:1
14Obstructed obturator hernia in 90 year olds-a management di- lemma显示文摘Ho YH Goh HS 1991Annals of the Academy of Medicine1991,20,3:1
15A rare case of 'giant' right-sided retroperitoneal bronchogenic cyst显示文摘Goh BK Chan HS Wong WK 0,,09:1
16Clinical and physiologic effects of biofeedback in outlet obstruction constipation显示文摘 Tan M Goh HS 1996Dis Colon Rectum1996,39,5:1
17Understanding the immunopathogenesis of chronic hepatitis B virus:an Asian prospective显示文摘Tan AT Koh HS Goh V 0,,06:1
18Hydrogen sulfide inhibits plasma rennin activity显示文摘Lu M Liu Y Goh HS 2010J Am Soe Nephrol2010,21,6:1
19A rare case of 'giant' right-sided retroperitoneal bronchogenic cyst显示文摘Goh BK Chan HS Wong WK 2004Dig Dis Sci2004,49,9:1
20Clinical and physiologic effect of biofeedback in outlet obstruction constipation 显示文摘Ho YH Tan M Goh HS 1996Dis Colon Rectum1996,39,:1
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