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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Heavy-tailed phenomena in satisfiability and constraint satisfaction problems显示文摘 | C Gomes B Selman N Crato | 2000 | Journal of Automatic Reasoning2000，24，12： | 1 |
| 3 | Mrf4 determines skeletal muscle identity in Myf5,Myod double- mutant mice显示文摘 | KASSAR-DUCHOSSOY L GAYRAUD-MOREL B GOMES D | 2004 | Nature2004，431，77： | 1 |
| 4 | Novel metaphors appear anomalous at least momentarily:evidence from N400显示文摘 | Tartter V Gomes H Dubrovsky B Molholm S. Vala-Stewart R | | 0，，80： | 1 |
| 5 | Resolution of persistent periapical infection by endodontic surgery显示文摘 | Ferreira F B Ferreira A L Gomes B P | 2004 | Int Endod J2004，37，1： | 1 |
| 6 | Erros in ground distortions due to settlement trough adjustment显示文摘 | CELESTINO T B GOMES R A M P and BORTOLUCCI A A | 2000 | Tunneling and underground Space Technology2000，15，1： | 1 |
| 7 | Post-transplant diabetes melli- tus显示文摘 | Gomes M B Cobas R A | 2009 | Diabetol Metab Syndr2009，1，1： | 1 |
| 8 | Livin, a novel inhibitor of apoptosis protein family member显示文摘 | Kasof G M Gomes B C | 2001 | J Biol Chem2001，276，： | 1 |
| 9 | Microorganisms from canals of root-filled teeth with periapical lesions显示文摘 | PINHEIRO E T GOMES B P FERRAZ C C | 2003 | Int Endod J2003，36，1： | 1 |
| 10 | Livin, a novel inhibitor of apoptosis protein family member 显示文摘 | Kasof G M Gomes B C | 2001 | J Biol Chem2001，276，5： | 1 |
| 11 | Reflection Z-scan technique for measurements of optical properties of surface显示文摘 | Petrov D V Gomes A S L de Arauújo C B | | 0，，： | 1 |
| 12 | Combining me- ta-learning and search techniques to select parameters for support vector machines 显示文摘 | Taciana A F Gomes Ricardo B C Prudeneio | 2012 | Neuroeomputing2012，75，1： | 1 |
| 13 | Apical ntrusion of debris and irrigants using two hand and three engine-driven instrumentation techniques 显示文摘 | Ferraz C C Gomes N V Gomes B P | 2001 | Int Endod J2001，34，5： | 1 |
| 14 | Livin, a novel inhibitor of apoptosis protein family member显示文摘 | Kasof G M Gomes B C | 2001 | J Biol Chem2001，276，5： | 1 |
| 15 | Errors in ground distortions due to settlement trough adjustment显示文摘 | Celestino T B Gomes R A M P Bortolucci A A | 2000 | Tunnelling and Underground Space Technology2000，15，1： | 1 |
| 16 | Advanced mod- eling and optimal operating strategy in emulsion copolymerization: application to styrene/MMA system 显示文摘 | ALHAMAD B ROMAGNOLI J A GOMES V G | 2005 | Chemical Engineering Sci- ence2005，60，10： | 1 |
| 17 | Livin, a novel inhibitor of apoptosis protein family member 显示文摘 | Kasof G M Gomes B C | 2001 | J Biol Chem2001，276，5： | 1 |
| 18 | Errors in Ground Distortions Due to Settlement Trough Adjustment 显示文摘 | Celestino T B Gomes R A M P Bortolucci A A | 2000 | Tunnelling and Underground Space Technology2000，15，1： | 1 |
| 19 | Livin,a novel inhibitor of apoptosisprotein family member显示文摘 | KASOF G M GOMES B C | 2001 | J Biol Chem2001，276，5： | 1 |
| 20 | On-line multi- variable predictive control of molar mass and particle size distribu- tions in free-radical emulsion copolymerization 显示文摘 | ALHAMAD B ROMAGNOLI J A GOMES V G | 2005 | Chemical Engi- neering Science2005，60，23： | 1 |
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