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| 1 | Therapeutic temperature modulation is associated with pulmonary complications in patients with severe traumatic brain injury显示文摘AIM: To examine complications associated with the use of therapeutic temperature modulation(mild hypothermia and normothermia) in patients with severe traumatic brain injury(TBI). METHODS: One hundred and fourteen charts were reviewed. Inclusion criteria were: severe TBI with Glasgow Coma Scale(GCS) < 9, intensive care unit(ICU) stay > 24 h and non-penetrating TBI. Patients were divided into two cohorts: the treatment group received therapeutic temperature modulation(TTM) with continuous surface cooling and indwelling bladder temperature probes. The control group received standard treatment with intermittent acetaminophen for fever. Information regarding complications during the time in the ICU was collected as follows: Pneumonia was identified using a combination of clinical and laboratory data. Pulmonary embolism, pneumothorax and deep venous thrombosis were identified based onimaging results. Cardiac arrhythmias and renal failure were extracted from the clinical documentation. acute respiratory distress syndrome and acute lung injury were determined based on chest imaging and arterial blood gas results. A logistic regression was conducted to predict hospital mortality and a multiple regression was used to assess number and type of clinical complications. RESULTS: One hundred and fourteen patients were included in the analysis(mean age = 41.4, SD = 19.1, 93 males), admitted to the Jackson Memorial Hospital Neuroscience ICU and Ryder Trauma Center(mean GCS = 4.67, range 3-9), were identified and included in the analysis. Method of injury included motor vehicle accident(n = 29), motor cycle crash(n = 220), blunt head trauma(n = 212), fall(n = 229), pedestrian hit by car(n = 216), and gunshot wound to the head(n = 27). Ethnicity was primarily Caucasian(n = 260), as well as Hispanic(n = 227) and African American(n = 223); four patients had unknown ethnicity. Patients received either TTM(43) or standard therapy(71). Within the TTM group eight patients were treated with normothermia after TBI and 35 patients were treated with hypothermia. A logistic regression predicting in hospital mortality with age, GCS, and TM demonstrated that GCS(Beta = 0.572, P < 0.01) and age(Beta =-0.029) but not temperature modulation(Beta = 0.797, ns) were significant predictors of in-hospital mortality [χ2(3) = 22.27, P < 0.01] A multiple regression predicting number of complications demonstrated that receiving TTM was the main contributor and was associated with a higher number of pulmonary complications(t =-3.425, P = 0.001). CONCLUSION: Exposure to TTM is associated with an increase in pulmonary complications. These findings support more attention to these complications in studies of TTM in TBI patients. | Kristine H O’Phelan Amedeo Merenda Katherine G Denny Kassandra E Zaila Cynthia Gonzalez | 2015 | World Journal of Critical Care Medicine2015，4，4： | 18 |
| 2 | Effect of Helicobacter pylori on gastric epithelial cells显示文摘The gastrointestinal epithelium has cells with features that make them a powerful line of defense in innate mucosal immunity. Features that allow gastrointestinal epithelial cells to contribute in innate defense include cell barrier integrity, cell turnover, autophagy, and innate immune responses. Helicobacter pylori(H. pylori) is a spiral shape gram negative bacterium that selectively colonizes the gastric epithelium of more than half of the world's population. The infection invariably becomes persistent due to highly specialized mechanisms that facilitate H. pylori 's avoidance of this initial line of host defense as well as adaptive immune mechanisms. The host response is thus unsuccessful in clearing the infection and as a result becomes established as a persistent infection promoting chronic inflammation. In some individuals the associated inflammation contributes to ulcerogenesis or neoplasia. H. pylori has an array of different strategies to interact intimately with epithelial cells and manipulate their cellular processes and functions. Among the multiple aspects that H. pylori affects in gastric epithelial cells are their distribution of epithelial junctions, DNA damage, apoptosis, proliferation, stimulation of cytokine production, and cell transformation. Some of these processes are initiated as a result of the activation of signaling mechanisms activated on binding of H. pylori to cell surface receptors or via soluble virulence factors that gain access to the epithelium. The multiple responses by the epithelium to the infection contribute to pathogenesis associated with H. pylori. | Shatha Alzahrani Taslima T Lina Jazmin Gonzalez Irina V Pinchuk Ellen J Beswick Victor E Reyes | 2014 | World Journal of Gastroenterology2014，20，36： | 15 |
| 3 | Immune evasion strategies used by Helicobacter pylori显示文摘Helicobacter pylori(H. pylori) is perhaps the most ubiquitous and successful human pathogen, since it colonizes the stomach of more than half of humankind. Infection with this bacterium is commonly acquired during childhood. Once infected, people carry the bacteria for decades or even for life, if not treated. Persistent infection with this pathogen causes gastritis, peptic ulcer disease and is also strongly associated with the development of gastric cancer. Despite induction of innate and adaptive immune responses in the infected individual, the host is unable to clear the bacteria. One widely accepted hallmark of H. pylori is that it successfully and stealthily evades host defense mechanisms. Though the gastric mucosa is well protected against infection, H. pylori is able to reside under the mucus, attach to gastric epithelial cells and cause persistent infection by evading immune responses mediated by host. In this review, we discuss how H. pylori avoids innate and acquired immune response elements, uses gastric epithelial cells as mediators to manipulate host T cell responses and uses virulence factors to avoid adaptive immune responses by T cells to establish a persistent infection. We also discuss in this review how the genetic diversity of this pathogen helps for its survival. | Taslima T Lina Shatha Alzahrani Jazmin Gonzalez Irina V Pinchuk Ellen J Beswick Victor E Reyes | 2014 | World Journal of Gastroenterology2014，20，36： | 7 |
| 4 | Selecting suitable solid organ transplant donors: Reducing the risk of donor-transmitted infections显示文摘Selection of the appropriate donor is essential to a successful allograft recipient outcome for solid organ transplantation. Multiple infectious diseases have been transmitted from the donor to the recipient via transplantation. Donor-transmitted infections cause increased morbidity and mortality to the recipient. In recent years, a series of high-profile transmissions of infections have occurred in organ recipients prompt-ing increased attention on the process of improving the selection of an appropriate donor that balances the shortage of needed allografts with an approach that mitigates the risk of donor-transmitted infection to the recipient. Important advances focused on improving donor screening diagnostics, using previously excluded high-risk donors, and individualizing the selection of allografts to recipients based on their prior infection history are serving to increase the donor pool and improve outcomes after transplant. This article serves to review the relevant literature surrounding this topic and to provide a suggested approach to the selection of an appropriate solid organ transplant donor. | Christopher S Kovacs Jr Christine E Koval David van Duin Amanda Guedes de Morais Blanca E Gonzalez Robin K Avery Steven D Mawhorter Kyle D Brizendine Eric D Cober Cyndee Miranda Rabin K Shrestha Lucileia Teixeira Sherif B Mossad | 2014 | World Journal of Transplantation2014，4，2： | 7 |
| 5 | Successful operation of a cooperative SLR station of China and Argentina in San Juan显示文摘We introduced the observations and researches using a Satellite Laser Ranging (SLR) system with high precision, which was designed and made in China and installed in the Observatory of San Juan Uni- versity, Argentina, the capability of the system and the achievement of the cooperative procedure be- tween China and Argentina. The SLR station in San Juan, set up by China and Argentina, is quite sig- nificant for improving the distribution of SLR stations and enhancing the orbital coverage of the whole earth. Since the SLR system started to work in the Observatory of San Juan University in the beginning of 2006, the operation is rather good, and rich data with high precision have been obtained. Further plan of the cooperation for the near future is also presented. | HAN YanBen LIU WeiDong E ACTIS R PODESTA WANG TanQiang GUO TangYong QU Feng A M PACHECO A A GONZALEZ E ALONSO XIANG QingGe HUANG DongPing YIN ZhiQiang | 2008 | Chinese Science Bulletin2008，53，16： | 2 |
| 6 | G-protein β3 subunit gene variant and left ventricular hypertrophy in essential hypertension显示文摘 | POCH E GONZALEZ D GOMEZ-ANGELATS E | 2000 | Hypertension2000，3512，： | 1 |
| 7 | Pluripotency of mesenchymal stem cells derived from adult marrow显示文摘 | Jiang Y Jahagirdar B N Reinhardt R L Schwartz R E Keene C D Ortiz Gonzalez X R | 2002 | Nature2002，418，： | 1 |
| 8 | Rate of potassium desorption, its velocity in Pampean Argiudolls (Argentina)显示文摘 | CONTI M E HORRA A M DE LA GONZALEZ M G | 1995 | Ciencia del Suelo1995，13，2： | 1 |
| 9 | Chemical state and distribution of Mn ions in the absence and the presence of fluxes显示文摘 | Navarrete E L Caballero A Gonzalez - Elipe A R | 2004 | Journal of the Europe Ceramic Society2004，，24： | 1 |
| 10 | Simultaneous nutrients and carbon removal during pretreated swine slurry degradation in a tubular biofilm photobioreactor 显示文摘 | de Godos I Gonzalez C Becares E | 2009 | Applied Microbiology and Biotechnology2009，82，1： | 1 |
| 11 | Vasoactive intestinal peptide induces regulatory T ceils during experimental autoimnmne encephalomyelitis 显示文摘 | FERNANDEZ MARTIN A GONZALEZ REY E CHORNY A et al | 2006 | Eur J Immunol2006，36，2： | 1 |
| 12 | Determining the importance of the supplier selection Process in manufacturing case study显示文摘 | Gonzalez M E Quesada G Monge C a M | 2004 | International Journal of Physical Distribution & Logistics Management2004，34，6： | 1 |
| 13 | A new frontier in soy bioactive peptides that may prevent age-related chronic diseases显示文摘 | WANG Wenyi GONZALEZ de MEJIA E | 2005 | Comprehensive Reviews in Food Science and Food Safety2005，4，4： | 1 |
| 14 | Volumetric locking in natural neighbour Galerkin methods显示文摘 | Gonzalez D Cueto E Doblare M | 2004 | International Journal for Numerical Methods in Engineering2004，61，： | 1 |
| 15 | Dosimetric characterization of a new preparation of BaSOa activated by Eu ions显示文摘 | GONZALEZ P R FURETTA C CALVO B E GASO M I CRUZ-ZARAGOZA E | 2007 | Nucl Instrum Meth B2007，260，： | 1 |
| 16 | Phosphate transporter traffic facilitatorl is a plant-specific SEC12-related protein thatenables the endoplasmic retieulum exit of a high-affinity phosphate transporter in Arabidopsis显示文摘 | Gonzalez E Solano R Rubio V | 2005 | Plant Cell2005，17，： | 1 |
| 17 | Prognstic value of inverted apilloma of the lower urinary tract显示文摘 | Nunez Mora C Rios Gonzalez E Garcia Mediero J M | 2001 | Arch Esp Urol2001，54，1： | 1 |
| 18 | Mesenteric lymph is responsible for post-hemorrhagic shock systemic neutrophil priming显示文摘 | Gonzalez R J Moore E E Ciesla D J | 2001 | J Trauma2001，51，6： | 1 |
| 19 | Speciation of mercuty by capillary electrophoresis -inductively coupled plasa mass spectrometry显示文摘 | DA-ROCHA S M SOLDADO A B BLANCO -GONZALEZ E | 2000 | Biomed Chromatogr2000，14，： | 1 |
| 20 | Effects of different carbon sources on the synthesis of pectinase by Aspergillus niger in submerged and solid state fermentations显示文摘 | S Sol-Pereira E Favela Torres G Viniegra Gonzalez | 1993 | Applied Microbiology and Biotechnology1993，39，1： | 1 |
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