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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 2 | A study on the friction and wear characteristics of brake pads for Al MMC brake disc 显示文摘 | Kwon S J Goo B C | 2000 | KeyEng Mat2000，183，1： | 2 |
| 3 | A noise optimization technique for integrated low-noise amplifiers显示文摘 | Goo J S Ahn H T Ladwig D J | 2002 | Journal of Solid-state Circuits IEEE2002，37，8： | 1 |
| 4 | Soybean a comparison of three methods for reducing iron-deficiency chlorosis in soybean显示文摘 | Goos R J Brian E J | 2000 | Agronomy Jour- nal2000，92，： | 1 |
| 5 | Epithelioid sarcoma:a frequently misdiagnosed neoplasm显示文摘 | Dissemond J Schultewolter T Goos M | 2001 | Acta Derm Venereol2001，81，2： | 1 |
| 6 | The African catfish,Clarias gariepinus,a model for the study of reproductive endocrinologyin teleosts显示文摘 | VAN OORDT P G W J GOOS H J Th | 1987 | Aquaculture1987，63，： | 1 |
| 7 | Coronary artery anomalies and clinically important anatomy in patients with congenital heart dis-ease:multislice CT findings显示文摘 | Goo HW Seo DM Yun T J | 2009 | Pediatr Radiol2009，39，3： | 1 |
| 8 | Temperature related study on PEM fuel cell显示文摘 | KIM J GOO Y JANG H R | 2004 | Science and Technology2004，1，： | 1 |
| 9 | The regulation of gonadotropin release by neurohormones and gonadal steroids in the African catfish, Clarias gariepinus 显示文摘 | De Leeuw R Goos H J Th Van Oordt P G W J | 1987 | Aquaculture1987，63，14： | 1 |
| 10 | CT of congenital heart disease: normal anatomy and typical pathologic conditions 显示文摘 | GOO H W PARK I S KO J K etal | 2003 | Radiographics2003，23，： | 1 |
| 11 | A study on the friction and wear characteristics of brake pads for Al MMC brake disc显示文摘 | Goo B C | 2000 | Key Eng Mat2000，183，1： | 1 |
| 12 | False positive and false negative FDG PET scans in various thoracic diseases显示文摘 | Chang JM Lee H J Goo J M | 2006 | Korean J Radiol2006，7，1： | 1 |
| 13 | Structural analysis of tape- wrapped structures 显示文摘 | Goo N S Yoon K J Heo S | 2005 | Computational Materials Science2005，34，： | 1 |
| 14 | Response of spring wheat to nitrogen fertilizers of different nitrification rates显示文摘 | Goos R J Schimelfenig J A Bock B R | 1999 | Agronomy Journal1999，91，2： | 1 |
| 15 | Bronchial anthracofibrosis (inflammatory bronchial stenosis with anthracotic pigmentation): CT findings显示文摘 | KIM H Y IM J G GOO J M | 2000 | Am J Roentgenol2000，174，： | 1 |
| 16 | Computation of flow over a flexible plate using the hybrid Cartesian/immersed boundary method 显示文摘 | Shin S Bae S Y Kim I C Kim Y J Goo J S | 2007 | International Journal for Numerical Methods in Fluids2007，55，： | 1 |
| 17 | Atypical pulmonary metastases: spectrum of radiologic finding 显示文摘 | Seo J U Im J G Goo J M | 2001 | Radio Graphics2001，21，2： | 1 |
| 18 | Pulmonary alveolar proteinosis versus exogenous lipoid pneumonia showing crazy-paving pattern: Comparison of their clinical features and high-resolution CT findings显示文摘 | CHOI H K PARK C M GOO J M | 2010 | Acta Radiol2010，51，4： | 1 |
| 19 | The Initial Stages of Template-Controlled CaCo3 Formation Revealed by Ctyo-TEM显示文摘 | Pouget E M Bnmans P H H Goos J A C M | 2009 | Science2009，323，5920： | 1 |
| 20 | The effect of pimozide-LHRHa and 17α-hydroxyprogesterone on plasma steroids and ovulation in the African catfish,Clarias gariepinus显示文摘 | RICHTER C J J EDING E H GOOS H J Th | 1987 | Aquaculture1987，63，： | 1 |
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