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| 1 | MicroRNAs and liver cancer associated with iron overload:Therapeutic targets unravelled显示文摘Primary liver cancer is a global disease that is on the increase.Hepatocellular carcinoma(HCC)accounts for most primary liver cancers and has a notably low survival rate,largely attributable to late diagnosis,resistance to treatment,tumour recurrence and metastasis.MicroRNAs(miRNAs/miRs)are regulatory RNAs that modulate protein synthesis.miRNAs are involved in several biological and pathological processes including the development and progression of HCC.Given the poor outcomes with current HCC treatments,miRNAs represent an important new target for therapeutic intervention.Several studies have demonstrated their role in HCC development and progression.While many risk factors underlie the development of HCC,one process commonly altered is iron homeostasis.Iron overload occurs in several liver diseases associated with the development of HCC including Hepatitis C infection and the importance of miRNAs in iron homeostasis and hepatic iron overload is well characterised.Aberrant miRNA expression in hepatic fibrosis and injury response have been reported,as have dysregulated miRNA expression patterns affecting cell cycle progression,evasion of apoptosis,invasion and metastasis.In2009,miR-26a delivery was shown to prevent HCC progression,highlighting its therapeutic potential.Several studies have since investigated the clinical potential of other miRNAs with one drug,Miravirsen,currently in phaseⅡclinical trials.miRNAs also have potential as biomarkers for the diagnosis of HCC and to evaluate treatment efficacy.Ongoing studies and clinical trials suggest miRNA-based treatments and diagnostic methods will have novel clinical applications for HCC in the coming years,yielding improved HCC survival rates and patient outcomes. | Catherine M Greene Robert B Varley Matthew W Lawless | 2013 | World Journal of Gastroenterology2013，19，32： | 5 |
| 2 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 3 | Synthesis and characterization of aerosol silicon nanocrystal nonvolatile floating-gate memory devices 显示文摘 | OSTRAAT M L DE BLAUWE J W GREEN M L | 2001 | Applied Physics Letters2001，79，3： | 1 |
| 4 | The Career Reasons of Minority Nascent Entrepreneurs 显示文摘 | Canner N M Gartner W B Greene P G | 2003 | Academy of Management Proceeding2003，18，1： | 1 |
| 5 | On secret sharing systems显示文摘 | Greene J W Hellman M E | 1983 | IEEE Transactions on Information Thcory1983，29，1： | 1 |
| 6 | Perform-ance Analysis of the Segment npn Anode LIGBT显示文摘 | GREEN D W SWEET M VERSHININ K V | 2005 | ElectronDevices IEEE Transactions on2005，52，11： | 1 |
| 7 | Infrared spectroscopic investigation of hydroxyl in β-(Mg,Fe)2SiO4 and coexisting olivine: implications for mantle evolution and dynamics显示文摘 | Young T E Green H W Hofmeister A M | 1993 | Phys Chem Minerals1993，19，： | 1 |
| 8 | The prevalence of nascent entrepreneurs in the United States: evidence from the panel study of entrepreneurial dynandler显示文摘 | Reynolds P D N M Carter W B Gartner P G Greene | 2004 | Small Business Economics2004，23，： | 1 |
| 9 | The soil and water assessment tools: historical development, ap- plications, and future research directions显示文摘 | Gassman P W Reyes M R Green C H | 2007 | Transac- tions of the ASABE2007，50，4： | 1 |
| 10 | The petroleum-in- ducible mixed function oxidase of cunner Tautogolabrus adspersus (Walbaum) : Some characteristics relevant to hydrocarbon moni- toring显示文摘 | WALTON D G PENROSE W R GREEN J M | 1978 | J Fish Res Board Can1978，35，12： | 1 |
| 11 | Concurrent and predictive validity of a self-reported measure of medication adherence显示文摘 | MORISKY D E GREEN L W LEVINE D M | 1986 | Med Care1986，24，1： | 1 |
| 12 | The soil and water assessment tool: historical development, applications, and future research directions 显示文摘 | Gassman P W Reyes M R Green C H | 2007 | American Society of Agriculture and Biology Engineers2007，50，4： | 1 |
| 13 | Coneurrent and pre-dictive va-lidity of aself-reported measure of medieation ad-herenee显示文摘 | MORLSKY D E GREEN L W LEVINE D M | 1986 | MedCare1986，24，1： | 1 |
| 14 | Study of the preparation and catalytic performance of molybdenum carbide catalysts prepared with C2H2/H2 carburizing mixture显示文摘 | XIAO T C WANG H T DA J W COLEMAN K S GREEN M L | 2002 | J Catal2002，211，1： | 1 |
| 15 | Microglial activation in human diabetic retinopathy显示文摘 | ZENG H Y GREEN W R TSO M O | 2008 | Arch Ophthalmol2008，126，2： | 1 |
| 16 | Rapid isolation in large numbers of intact,viable,individual hair follicles from skin:biochemical and ultrastructural characterization显示文摘 | GREEN M R CLAY C S GIBSON W T | 1986 | J Invest Dermatol1986，87，6： | 1 |
| 17 | UK evidence on the market valuation of research and development ex- penditures 显示文摘 | Green J P Stark A W Thomas H M | 1996 | Journal of Business Finance and Accounting1996，23，2： | 1 |
| 18 | Calibration of storm loads in the South Prong watershed, Florida, using BASIN/HSPF 显示文摘 | Bergman M J Green W Donnangelo L J | 2002 | Journal of the American Water Resources Association2002，38，5： | 1 |
| 19 | Argyria显示文摘 | Greene R M Su W P D | 1987 | American Family Physician1987，36，6： | 1 |
| 20 | Two-scale mechanism-based theory of nonlinear viscoelasticity显示文摘 | TANG S GREENE M S LIU W K | 2012 | Journal of the Mechanics and Physics of Solids2012，60，2： | 1 |
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