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| 1 | Significant association between ABO blood group and pancreatic cancer显示文摘AIM:To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United States.METHODS:Using the University of Pittsburgh's clinicalpancreatic cancer registry,the blood donor database from our local blood bank (Central Blood Bank),and the blood product recipient database from the regional transfusion service (Centralized Transfusion Service) in Pittsburgh,Pennsylvania,we identified 274 pancreatic cancer patients with previously determined serological ABO blood group information.The ABO blood group frequency was compared between these patients and 708842 individual,community-based blood donors who had made donations to Pittsburgh's Central Blood Bank between 1979 and 2009.RESULTS:The frequency of blood group A was statistically significantly higher amongst pancreatic cancer patients compared to its frequency amongst the regional blood donors [47.63% vs 39.10%,odds ratio (OR)=1.43,P=0.004].Conversely,the frequency of blood group O was significantly lower amongst pancreatic cancer patients relative to the community blood donors (32.12% vs 43.99%,OR=0.60,P=0.00007).There were limited blood group B (n=38) and AB (n=17) pancreatic cancer patients;the overall P trend value comparing patient to donor blood groups was 0.001.CONCLUSION:The ABO blood group is associated with pancreatic cancer risk.Future studies should examine the mechanism linking pancreatic cancer risk to ABO blood group. | Julia B Greer Mark H Yazer Jay S Raval M Michael Barmada Randall E Brand David C Whitcomb | 2010 | World Journal of Gastroenterology2010，16，44： | 10 |
| 2 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 3 | The generic relationships of the scincid liz- ard genus Leiolopisma and its relatives 显示文摘 | GREER A E | 1974 | Australian Journal of Zoology Supplemental Series1974，22，31： | 1 |
| 4 | FOXO transcription factors at the interface between longevity and tumor suppression显示文摘 | GREER E L BRUNET A | 2005 | Oncogene2005，24，50： | 1 |
| 5 | Paradoxical elevation in adiponectin concentrations in women with preeclampsia 显示文摘 | Ramsay J E Jamieson N Greer I A | 2004 | Hypertension2004，42，5： | 1 |
| 6 | Grain refinement of A1 alloys: Mechanisms determining as-cast grain size in directional solidification 显示文摘 | QUESTED T E GREER A L | 2005 | Acta Materialia2005，53，： | 1 |
| 7 | Class of Decomposable Poverty Measures显示文摘 | FOLTER J GREER J THORBECKE E A | 1984 | Econometrica1984，52，： | 1 |
| 8 | Techniques for applying subatmospheric pressure dressing to wounds in difficult regions of anatomy显示文摘 | Greer SE Duthie E Cartolano B | 1999 | J Wound Ostomy Continence Nurs1999，26，5： | 1 |
| 9 | A class of deeomposable poverty measures 显示文摘 | FOSTER J GREER J THORBECHE E | 1984 | Econometrica1984，52，： | 1 |
| 10 | Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class Ⅱ enhanceosome formation显示文摘 | Zika E Greer S F Zhu X S | 2003 | Mol Cell Biol2003，23，9： | 1 |
| 11 | The occurrence of endosperm cells in wheat flour显示文摘 | Greer E N Hinton J J C Jones C R | 1951 | Cereal Chem1951，28，： | 1 |
| 12 | Comprehensive analysis of citrate effects during plateletpheresis in normal donors显示文摘 | Charles D Bolan S E Greer SA | 2001 | Transfusion2001，41，9： | 1 |
| 13 | A subfamilial classification of scincid liz- ards显示文摘 | GREER A E | 1970 | Bulletin of the Museum of Comparative Zoolo- gy1970，139，： | 1 |
| 14 | Microbial functional potential and community composition in permafrost-affected soils of the NW Canadian Arctic显示文摘 | FRANK-FAHLE B A YERGEAU E GREER C W | 2014 | The Public Library of Science2014，9，84： | 1 |
| 15 | Yeast Coexpression of human papillomavirus types 6 and 16 capsid proteins显示文摘 | Buonamassa D T Greer C E Capo S | 2002 | Virology2002，293，2： | 1 |
| 16 | A class of decomposa- ble poverty measures显示文摘 | Foster J Greer J Thorbecke E | 1984 | Econometrica1984，，52： | 1 |
| 17 | Techniques for applying subatmospheric pressure dressing to wounds in difficult regions of anatomy显示文摘 | Greer SE Duthie E Cartolano B | | 0，，05： | 1 |
| 18 | Phase Ⅲ trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage Ⅲ ovarian cancer: a Gynecologic Oncology Group study显示文摘 | Ozols R F Bundy B N Greer B E | 2003 | J Clin Oncol2003，21，17： | 1 |
| 19 | The alpha2 helix in the DNA ligase IV BRCT-I domain is required for targeted degradation of ligase IV during adenovirus infection显示文摘 | Gilson T Greer A E Vindigni A | 2012 | Virology2012，428，2： | 1 |
| 20 | Carbon distribution and losses: erosion and deposition effects显示文摘 | Gregorich E G Greer K J Anderson D W | 1998 | Soil and Tillage Research1998，47，： | 1 |
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