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| 1 | Significant association between ABO blood group and pancreatic cancer显示文摘AIM:To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United States.METHODS:Using the University of Pittsburgh's clinicalpancreatic cancer registry,the blood donor database from our local blood bank (Central Blood Bank),and the blood product recipient database from the regional transfusion service (Centralized Transfusion Service) in Pittsburgh,Pennsylvania,we identified 274 pancreatic cancer patients with previously determined serological ABO blood group information.The ABO blood group frequency was compared between these patients and 708842 individual,community-based blood donors who had made donations to Pittsburgh's Central Blood Bank between 1979 and 2009.RESULTS:The frequency of blood group A was statistically significantly higher amongst pancreatic cancer patients compared to its frequency amongst the regional blood donors [47.63% vs 39.10%,odds ratio (OR)=1.43,P=0.004].Conversely,the frequency of blood group O was significantly lower amongst pancreatic cancer patients relative to the community blood donors (32.12% vs 43.99%,OR=0.60,P=0.00007).There were limited blood group B (n=38) and AB (n=17) pancreatic cancer patients;the overall P trend value comparing patient to donor blood groups was 0.001.CONCLUSION:The ABO blood group is associated with pancreatic cancer risk.Future studies should examine the mechanism linking pancreatic cancer risk to ABO blood group. | Julia B Greer Mark H Yazer Jay S Raval M Michael Barmada Randall E Brand David C Whitcomb | 2010 | World Journal of Gastroenterology2010，16，44： | 10 |
| 2 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 3 | Regulation of adiposity by dietary calcium显示文摘 | ZEMEL M B SHI H GREER B | 2000 | FASEB Journal2000，14，： | 2 |
| 4 | Formation of bulk metallic glass by fluxing显示文摘 | KUI W H GREER A L TURNBULL D | 1984 | Applied Physics Letters1984，45，6： | 1 |
| 5 | Making metallic glasses plastic by control of residual stress 显示文摘 | ZHANG Y WANG W H GREER A L | 2006 | Nat Mater2006，5，： | 1 |
| 6 | Formation of bulk metallic glass by fluxing显示文摘 | Kui H W Greer A L Turnbull D | 1984 | Applied Physics Letters1984，45，6： | 1 |
| 7 | Regulation of adiposity by dietary calcium 显示文摘 | Zemel MB Shi H Greer B | 2000 | FASEB J2000，14，9： | 1 |
| 8 | Photoinhibition of photosynthesis in intact bean leaves : the role of light and temperature and requirement for chloroplast-protein synthesis during recovery显示文摘 | Greer G H Berry J A Bjorkman O | 1986 | Planta1986，，168： | 1 |
| 9 | Strong responses of growth and photosynthesis of five C3 pasture species to elevated CO2 at low temperatures显示文摘 | Laing W A Greer D H Campbell B D | 2002 | Functional Plant Biology2002，29，9： | 1 |
| 10 | Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact显示文摘 | Wang X Chun SJ Treloar H Vartanian T Greer CA Strittmatter SM | 2002 | J Neurosci2002，22，13： | 1 |
| 11 | Intrinsic plasticity or brittleness of metallic glasses显示文摘 | Lewandowski J J Wang W H Greer A L | 2005 | Philosophical Magazine Letters2005，85，2： | 1 |
| 12 | A Pilot randomized controlled trial of brief cognitive-behavioral therapy for anxiety in patients with terminal cancer 显示文摘 | Greer JA Traeger L Bemis H | 2012 | Oncologist2012，17，10： | 1 |
| 13 | Regulation of adiposity by dietary calcium 显示文摘 | Zemel MB Shi H Greer B | 2000 | FASEB J2000，14，9： | 1 |
| 14 | Photo inhibition of photosynthesis in intact kiwifruit( Ac- tinidia deliciosa) leaves: Effect of temperature显示文摘 | Laing W A Kipnis T | 1988 | Planta1988，174，： | 1 |
| 15 | Understanding the glass-forming ability Cu50Zr50 alloys in terms of a metastable euteetic显示文摘 | WANG W H LEWANDOWSKI J J GREER A L | 2005 | Journal of Materials Research2005，20，9： | 1 |
| 16 | Making metallic glasses plastic by control of residual stress 显示文摘 | ZHANG Y WANG W H GREER A L | 2006 | Nat Mater2006，5，： | 1 |
| 17 | Maximum-likelihood multiresolution laser radar range imaging 显示文摘 | GREER D R FUNG I SHAPIRO J H | 1997 | IEEE Transactions on Image Processing1997，6，1： | 1 |
| 18 | Photoichibitinn of photosynthesis in intact bean leaves: role of light and temperature and requirements for chloroplast-protein synthesis during recovery显示文摘 | GREER G H BENY J A BJORKMAN O | 1986 | Planta1986，168，： | 1 |
| 19 | Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase显示文摘 | Brunet A Sweeney L B Sturgill J F Chua K F Greer P L Lin Y Tran H Ross S E Mostoslavsky R Cohen H Y Hu L S Cheng H L Jedrychowski M P Gygi S P Sinclair D A Alt F W Greenberg M E | | 0，，5666： | 1 |
| 20 | New studies of nucleation mechanis in aluminium alloys: Implications for grain refinement practice 显示文摘 | SCHUMACHER P GREER A L WORTH J EVANS P V KEARNS M A FISHER P GREEN A H | 1998 | Materials Science and Technology1998，14，： | 1 |
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