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| 1 | From the Gla domain to a novel small-molecule detector of apoptosis显示文摘Apoptosis 在众多的医药混乱的病原学或致病起一个枢轴的作用,并且这样, apoptotic 房间指向可以实质地推进耐心的照顾。在我们为为 apoptosis 的新奇 low-molecular-weight 探针的探索,我们集中了于不平常的氨基酸纬 - carboxyglutamic 酸(Gla ) ,它在 clotting 因素的绑定起一个重要作用到否定地控告的 phospholipid 表面。基于 Gla 的 alkyl-malonic 酸主题,我们开发了并且现在介绍 ML-10 (2-(5-fluoro-pentyl )-2-methyl-malonic 酸, MW=206 Da ) , apoptosis 的小分子的察觉者的一个新奇家庭的原型的成员。ML-10 被发现在 apoptotic 房间执行选择举起和累积,当从可行或坏死的房间被排除时。有 caspase 激活, Annexin-V 绑定和 mitochondrial 膜潜力的混乱的 apoptotic 特点的 ML-10 举起相互关联。malonate 一半被发现为在 apoptosis 察觉的 ML-10 功能关键。ML-10 在早 apoptosis 对房间的特征的唯一的建筑群作出回应,包括膜潜力,房间膜和细胞质的永久使发酸,和膜正直的保藏的不可逆的损失。ML-10 因此是迄今为止知道的最紧缩的 apoptosis 探查。由于它的氟的符号原子, ML-10 对顺从与 18F 同位素标记收音机,向它为 apoptosis 的临床的正电子排放断层摄影术成像的潜在的未来使用。 | Avi Cohen Anat Shirvan Galit Levin Hagit Grimberg Ayelet Reshef Ilan Ziv | 2009 | Cell Research2009，19，5： | 12 |
| 2 | Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis 显示文摘 | Grimberg A Cohen P | 2000 | Journal of Cellular Physiology2000，183，3： | 1 |
| 3 | Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis 显示文摘 | Grimberg A Cohen P | 2000 | J Cell Physiol2000，183，： | 1 |
| 4 | Impact of P-glycoprotein on clopidogrel absorption显示文摘 | Taubert D von Beckerath N Grimberg G | 2006 | Clin Pharmacol Ther2006，80，5： | 1 |
| 5 | Can a doublerow anchorage technique improve tendon healing in arthroscopie rotator cuff repair: a prospective, nonrandomized,comparative study of double - row and single - row anchorage techniques with computed tomographic arthrography tendon healingassessment 显示文摘 | Charousset C Grimberg J Duranthon LD | 2007 | Am J Sports Med2007，35，8： | 1 |
| 6 | Multicomponent Ti-Zr-N and Ti-Nb-N coatings deposited by vacuum arc显示文摘 | GRIMBERG I ZHITOMIRSKY V M BOXMAN R L GOLDSMITH S WEISS B Z | 1998 | Surface and Coatings Technology1998，，： | 1 |
| 7 | 2D eddy current sensor array显示文摘 | Grimberg R Udpa L Savin A | 2006 | NDT & E International2006，39，4： | 1 |
| 8 | Role of insulin-like growth factors and their binding proteins in growth control and carcino- genesis 显示文摘 | Grimberg A Cohen P | 2000 | J Cell Physiol2000，183，1： | 1 |
| 9 | Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis显示文摘 | Grimberg A Cohen P | 2000 | J Cell Physiol2000，183，1： | 1 |
| 10 | Can a double-row anchorage technique improve tendon healing in arthroscopic rotator cuff repair? A prospective,nonrandomized,comparative study of double-row and single-row anchorage techniques with computed tomographic arthrography tendon healing assess显示文摘 | Charousset C Grimberg J Duranthon LD | 2007 | Am J Sports Med2007，35，8： | 1 |
| 11 | Vacuum Arc De-position and Microstructure of ZrN Based Coatings显示文摘 | Zhitomirsky V N Grimberg I Boxman RL | 1997 | Surfand Coat Technology1997，9495，2： | 1 |
| 12 | Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis显示文摘 | Grimberg A Cohen P | 2000 | J Cell Physiol2000，183，1： | 1 |
| 13 | Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis 显示文摘 | Grimberg A Cohen P | 2000 | J Cell Physiol2000，183，1： | 1 |
| 14 | Novel molecular imaging of cell death in experimental cerebral stroke显示文摘 | Reshef A Shirvan A Grimberg H | 2007 | Brain Res2007，1144，4： | 1 |
| 15 | Surfactant enhanced dissolution of phenanthrene into water for laminar flow condition 显示文摘 | Grimberg S J Miller C T Aitken M D | 1996 | Environ Sci Technol1996，30，10： | 1 |
| 16 | A simple and effic1ent non-organic procedure for the isolation of genomic DNA from blood显示文摘 | Grimberg J Nawoschik S Belluscio L | 1989 | Nucleic Acids Res1989，17，： | 1 |
| 17 | Molecular imaging of cell death in vivo by a novel small molecule probe 显示文摘 | Aloya R Shirvan A Grimberg H | 2006 | Apoptosis2006，11，12： | 1 |
| 18 | Fuzzy inference system used for a quantitative evaluation of the material discontinuities detected by eddy current sensors显示文摘 | Grimberg R Savin A | 2000 | Sensorsand Actuators2000，81，： | 1 |
| 19 | Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis 显示文摘 | Grimberg A Cohen P | 2000 | J Cell Physiol2000，183，1： | 1 |
| 20 | Impact of P-glycopmtein on clopidogrel absorption显示文摘 | Taubert D von Beckerath N Grimberg G | 2006 | Clin Pharmacol Ther2006，80，5： | 1 |
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