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| 1 | Hepatocellular carcinoma in cirrhotic patients with portal hypertension:Is liver resection always contraindicated?显示文摘AIM:To analyze the outcome of hepatocellular car-cinoma(HCC)resection in cirrhosis patients,related to presence of portal hypertension(PH)and extent of hepatectomy.METHODS:A retrospective analysis of 135 patients with HCC on a background of cirrhosis was submitted to curative liver resection.RESULTS:PH was present in 44(32.5%)patients.Overall mortality and morbidity were 2.2% and 33.7%,respectively.Median survival time in patients with or without PH was 31.6 and 65.1 mo,respectively(P=0.047);in the subgroup with Child-Pugh class A cirrhosis,median survival was 65.1 mo and 60.5 mo,respectively(P=0.257).Survival for patients submitted to limited liver resection was not significantly different in presence or absence of PH.Conversely,median survival for patients after resection of 2 or more segments with or without PH was 64.4 mo and 163.9 mo,respectively(P=0.035).CONCLUSION:PH is not an absolute contraindication to liver resection in Child-Pugh class A cirrhotic patients,but resection of 2 or more segments should not be recommended in patients with PH. | Andrea Ruzzenente Alessandro Valdegamberi Tommaso Campagnaro Simone Conci Silvia Pachera Calogero Iacono Alfredo Guglielmi | 2011 | World Journal of Gastroenterology2011，17，46： | 20 |
| 2 | Hepatocellular carcinoma:Surgical perspectives beyond the barcelona clinic liver cancer recommendations显示文摘The barcelona clinic liver cancer(BCLC)staging system has been approved as guidance for hepatocellular carcinoma(HCC)treatment guidelines by the main Western clinical liver associations.According to the BCLC classification,only patients with a small single HCC nodule without signs of portal hypertension or hyperbilirubinemia should undergo liver resection.In contrast,patients with intermediate-advanced HCC should be scheduled for palliative therapies,even if the lesion is resectable.Recent studies report good short-term and long-term outcomes in patients with intermediate-advanced HCC treated by liver resection.Therefore,this classification has been criticised because it excludes many patients who could benefit from curative resection.The aim of this review was to evaluate the role of surgery beyond the BCLC recommendations.Safe liver resection can be performed in patients with portal hypertension and well-compensated liver function with a 5-year survival rate of 50%.Surgery also offers good long-term result in selected patients with multiple or large HCCs with a reported 5-year survival rate of over 50%and 40%,respectively.Although macrovascular invasion is associated with a poor prognosis,liver resection provides better long-term results than palliative therapies or best supportive care.Recently,researchers have identified several genes whose altered expression influences the prognosis of patients with HCC.These genes may be useful for classifying the biological behaviour of different tumours.A revision of the BCLC classification should be introduced to provide the best treatment strategy and to ensure the best prognosis in patients with HCC. | Alfredo Guglielmi rea Ruzzenente Simone Conci Alessro Valdegamberi Marco Vitali Francesca Bertuzzo Michela De Angelis Guido Mantovani Calogero Iacono | 2014 | World Journal of Gastroenterology2014，20，24： | 16 |
| 3 | Endoscopic ablation of Barrett's esophagus using high power setting argon plasma coagulation: A prospective study显示文摘AIM: This prospective study evaluated the effectiveness of 90 W argon plasma coagulation (APC) for the ablation of Barrett's esophagus (BE) that is considered to be the main risk factor for the development of esophageal adenocarcinoma.METHODS: The results from 25 patients, observed at the First Department of General Surgery, University of Verona, Italy, from October 2000 to October 2003, who underwent APC for histologically proven BE were prospectively analyzed.RESULTS: The ablation treatment was completed in all the patients but one (96%). The mean number of APC sessions needed to complete ablation was 1.6 (total number: 40). The eradication was obtained in the majority of cases by one session only (60%), two sessions were required in 24% of the cases and three or more in 16%.About 43% of the sessions were complicated. Retrosternal pain (22.5%) and fever (17.5%) were the most frequent symptoms. Only one major complication occurred, it was an hemorrhage due to ulcer formation on the treated esophagus that required urgent endoscopic sclerosis and admission. The follow-up was accomplished in all the patients with a mean period of 26.3 mo and 20 patients (84%) with a follow-up period longer than 24 mo. Only one patient showed a relapse of metaplastic mucosa 12 mo after the completion of ablation. The patient was hence re-treated and now is free from recurrence 33 mo later.CONCLUSION: High power setting (90 W) APC showed to be safe and effective. The effects persist at a mean follow-up period of two years with a comparable cost in term of complications with respect to standard power settings. Further studies with greater number of patients are required to confirm these results and to assess if ablation reduces the incidence of malignant progression. | Corrado Pedrazzani Filippo Catalano Mara Festini Germana Zerman Anna Tomezzoli Andrea Ruzzenente Alfredo Guglielmi Giovanni de Manzoni | 2005 | World Journal of Gastroenterology2005，11，12： | 14 |
| 4 | Central pancreatectomy: The Dagradi Serio Iacono operation. Evolution of a surgical technique from the pioneers to the robotic approach显示文摘Central pancreatectomy(CP) is a parenchyma-sparing surgical procedure. The aims are to clarify the history and the development of CP and to give credits to those from whom it came. Ehrhardt, in 1908, described segmental neck resection(SNR) followed, in 1910, by Finney without reconstructive part. In 1950 Honjyo described two cases of SNR combined with gastrectomy for gastric cancer infiltrating the neck of the pancreas. Guillemin and Bessot(1957) and Letton and Wilson(1959) dealt only with the reconstructive aspect of CP. Dagradi and Serio, in 1982, performed the first CP including the resective and reconstructive aspects. Subsequently Iacono has validated it with functional endocrine and exocrine tests and popularized it worldwide. In 2003, Baca and Bokan performed laparoscopic CP and, In 2004, Giulianotti et al performed a robotic assisted CP. CP is performed worldwide either by open surgery or by using minimally-invasive or robotic approaches. This confirms that the operation does not belong to whom introduced it but to everyone who carries out it; however credit must be given to those from whom it came. | Calogero Iacono Andrea Ruzzenente Luca Bortolasi Alfredo Guglielmi | 2014 | World Journal of Gastroenterology2014，20，42： | 13 |
| 5 | 'Charge while driving'for electric vehicles:road traffic modeling and energy assessment显示文摘The aim of this research study is to present a method for analyzing the performance of the wireless inductive charge-while-driving(CWD)electric vehicles,from both traffic and energy points of view.To accurately quantify the electric power required from an energy supplier for the proper management of the charging system,a traffic simulation model is implemented.This model is based on a mesoscopic approach,and it is applied to a freight distribution scenario.Lane changing and positioning are managed according to a cooperative system among vehicles and supported by advanced driver assistance systems(ADAS).From the energy point of view,the analyses indicate that the traffic may have the following effects on the energy of the system:in a low traffic level scenario,the maximum power that should be supplied for the entire road is simulated at approximately 9 MW;and in a high level traffic scenario with lower average speeds,the maximum power required by the vehicles in the charging lane increases by more than 50%. | Francesco Paolo DEFLORIO Luca CASTELLO Ivano PINNA Paolo GUGLIELMI | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，2： | 10 |
| 6 | Prognostication and response assessment in liver and pancreatic tumors:The new imaging显示文摘Diffusion-weighted imaging(DWI), dynamic contrastenhanced magnetic resonance imaging(DCE-MRI) and perfusion computed tomography(CT) are technical improvements of morphologic imaging that can evaluate functional properties of hepato-bilio-pancreatic tumors during conventional MRI or CT examinations.Nevertheless, the term 'functional imaging' is commonly used to describe molecular imaging techniques, as positron emission tomography(PET)CT/MRI, which still represent the most widely used methods for the evaluation of functional properties of solid neoplasms; unlike PET or single photon emission computed tomography, functional imaging techniques applied to conventional MRI/CT examinations do not require the administration of radiolabeled drugs or specific equipments. Moreover, DWI and DCE-MRI can be performed during the same session, thus providing a comprehensive 'one-step' morphological and functional evaluation of hepato-bilio-pancreatic tumors. Literature data reveal that functional imaging techniques could be proposed for the evaluation of these tumors before treatment, given that they may improve staging and predict prognosis or clinical outcome. Microscopic changes within neoplastic tissues induced by treatments can be detected and quantified with functional imaging,therefore these techniques could be used also for posttreatment assessment, even at an early stage. The aim of this editorial is to describe possible applications of new functional imaging techniques apart frommolecular imaging to hepatic and pancreatic tumors through a review of up-to-date literature data, with a particular emphasis on pathological correlations,prognostic stratification and post-treatment monitoring. | Riccardo De Robertis Paolo Tinazzi Martini Emanuele Demozzi Gino Puntel Silvia Ortolani Sara Cingarlini Andrea Ruzzenente Alfredo Guglielmi Giampaolo Tortora Claudio Bassi Paolo Pederzoli Mirko D'Onofrio | 2015 | World Journal of Gastroenterology2015，21，22： | 10 |
| 7 | Elevated fibrinogen plasma level is not an independent predictor of poor prognosis in a large cohort of Western patients undergoing surgery for colorectal cancer显示文摘AIM To evaluate the clinical significance of the preoperative fibrinogen plasma level as a prognostic marker after surgery for colorectal cancer.METHODS This retrospective study analysed 652 patients undergoing surgery for stage Ⅰ-Ⅳ colorectal cancer between January 2005 and December 2012, at the Division of General Surgery A, University of Verona Hospital Trust, in whom preoperative fibrinogen plasma values were assessed at baseline. Fibrinogen is involved in tumourigenesis as well as tumour progression in several malignancies. Correlations between preoperative plasma fibrinogen values and clinicopathological characteristics were investigated. Univariate and multivariate survival analyses were performed to identify factors associated with overall and tumour-related survival.RESULTS Among the 652 patients, the fibrinogen value was higher than the threshold of 400 mg/dL in 345 patients(53%). The preoperative mean ± SD of fibrinogen was 426.2 ± 23.2 mg/dL(median: 409 mg/dL; range: 143-1045 mg/d L). Preoperative fibrinogen values correlated with age(P = 0.003), completeness of tumour resection, potentially curative vs palliative(P < 0.001), presence of systemic metastasis(P < 0.001), depth of tumour invasion p T(P < 0.001), nodes involvement p N(P = 0.001) and CEA serum level(P < 0.001). The mean fibrinogen value(± SD) was 395.6 ± 120.4 mg/d L in G1 tumours, 424.1 ± 121.4 mg/dL in G2 tumours and 453.4 ± 131.6 mg/dL in G3 tumours(P = 0.045). The overall survival and tumourrelated survival were significantly higher in patients with fibrinogen values ≤ 400 mg/d L(P < 0.001). However, hyperfibrinogenemia did not retain statistical significance regarding either overall(P = 0.313) or tumour-related survival(P = 0.355) after controlling for other risk factors in a multivariate analysis.CONCLUSION Preoperative fibrinogen levels correlate with cancer severity but do not help in predicting patient prognosis after colorectal cancer surgery. | Corrado Pedrazzani Guido Mantovani Gian Luca Salvagno Elisabeth Baldiotti Andrea Ruzzenente Calogero Iacono Giuseppe Lippi Alfredo Guglielmi | 2016 | World Journal of Gastroenterology2016，22，45： | 5 |
| 8 | Fault activation and induced seismicity in geological carbon storage--Lessons learned from recent modeling studies显示文摘In the light of current concerns related to induced seismicity associated with geological carbon sequestration(GCS),this paper summarizes lessons learned from recent modeling studies on fault activation,induced seismicity,and potential for leakage associated with deep underground carbon dioxide(CO_2) injection.Model simulations demonstrate that seismic events large enough to be felt by humans require brittle fault properties and continuous fault permeability allowing pressure to be distributed over a large fault patch to be ruptured at once.Heterogeneous fault properties,which are commonly encountered in faults intersecting multilayered shale/sandstone sequences,effectively reduce the likelihood of inducing felt seismicity and also effectively impede upward CO_2 leakage.A number of simulations show that even a sizable seismic event that could be felt may not be capable of opening a new flow path across the entire thickness of an overlying caprock and it is very unlikely to cross a system of multiple overlying caprock units.Site-specific model simulations of the In Salah CO_2 storage demonstration site showed that deep fractured zone responses and associated microseismicity occurred in the brittle fractured sandstone reservoir,but at a very substantial reservoir overpressure close to the magnitude of the least principal stress.We conclude by emphasizing the importance of site investigation to characterize rock properties and if at all possible to avoid brittle rock such as proximity of crystalline basement or sites in hard and brittle sedimentary sequences that are more prone to injection-induced seismicity and permanent damage. | Jonny Rutqvist Antonio P. Rinaldi Frederic Cappa Pierre Jeanne Alberto Mazzoldi Luca Urpi Yves Guglielmi Victor Vilarrasa | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，6： | 4 |
| 9 | Unscrambling light-automatically undoing strong mixing between modes显示文摘Propagation of light beams through scattering or multimode systems may lead to the randomization of the spatial coherence of the light.Although information is not lost,its recovery requires a coherent interferometric reconstruction of the original signals,which have been scrambled into the modes of the scattering system.Here we show that we can automatically unscramble optical beams that have been arbitrarily mixed in a multimode waveguide,undoing the scattering and mixing between the spatial modes through a mesh of silicon photonics tuneable beam splitters.Transparent light detectors integrated in a photonic chip are used to directly monitor the evolution of each mode along the mesh,allowing sequential tuning and adaptive individual feedback control of each beam splitter.The entire mesh self-configures automatically through a progressive tuning algorithm and resets itself after significantly perturbing the mixing,without turning off the beams.We demonstrate information recovery by the simultaneous unscrambling,sorting and tracking of four mixed modes,with residual cross-talk of−20 dB between the beams.Circuit partitioning assisted by transparent detectors enables scalability to meshes with a higher port count and to a higher number of modes without a proportionate increase in the control complexity.The principle of self-configuring and self-resetting in optical systems should be applicable in a wide range of optical applications. | Andrea Annoni Emanuele Guglielmi Marco Carminati Giorgio Ferrari Marco Sampietro David AB Miller Andrea Melloni Francesco Morichetti | 2017 | Light(Science & Applications)2017，6，1： | 4 |
| 10 | Impact of age on feasibility and short-term outcomes of ERAS after laparoscopic colorectal resection显示文摘BACKGROUND There is still large debate on feasibility and advantages of fast-track protocols in elderly population after colorectal surgery.AIM To investigate the impact of age on feasibility and short-term results of enhanced recovery protocol(ERP)after laparoscopic colorectal resection.METHODS Data from 225 patients undergoing laparoscopic colorectal resection and ERP between March 2014 and July 2018 were retrospectively analyzed.Three groups were considered according to patients’age:Group A,65 years old or less,Group B,66 to 75 years old and Group C,76 years old or more.Clinic and pathological data were compared amongst groups together with post-operative outcomes including post-operative overall and surgery-specific complications,mortality and readmission rate.Differences in post-operative length of stay and adherence to ERP’s items were evaluated in the three study groups.RESULTS Among the 225 patients,112 belonged to Group A,57 to Group B and 56 to Group C.Thirty-day overall morbidity was 32.9%whilst mortality was nihil.Though the percentage of complications progressively increased with age(25.9%vs 36.8%vs 42.9%),no differences were observed in the rate of major complications(4.5%vs 3.5%vs 1.8%),prolonged post-operative ileus(6.2%vs 12.2%vs 10.7%)and anastomotic leak(2.7%vs 1.8%vs 1.8%).Significant differences in recovery outcomes between groups were observed such as delayed urinary catheter removal(P=0.032)and autonomous deambulation(P=0.013)in elderly patients.Although discharge criteria were achieved later in older patients(3 d vs 3 d vs 4 d,P=0.040),post-operative length of stay was similar in the 3 groups(5 d vs 6 d vs 6 d).CONCLUSION ERPs can be successfully and safely applied in elderly undergoing laparoscopic colorectal resection. | Corrado Pedrazzani Cristian Conti Giulia Turri Enrico Lazzarini Marzia Tripepi Giovanni Scotton Matteo Rivelli Alfredo Guglielmi | 2019 | World Journal of Gastrointestinal Surgery2019，11，10： | 4 |
| 11 | Surgical Resection Versus Local Ablation for HCC on Cirrhosis: Results from a Propensity Case-Matched Study显示文摘 | Andrea Ruzzenente Alfredo Guglielmi Marco Sandri Tommaso Campagnaro Alessandro Valdegamberi Simone Conci Fabio Bagante Gianni Turcato Mirko D’Onofrio Calogero Iacono | 2012 | Journal of Gastrointestinal Surgery2012，，2： | 3 |
| 12 | Transhepatic fibrinolysis of mesenteric and portal vein thrombosis in a patient with uIterative colitis: A case report显示文摘AIM: To present a case of acute mesenteric and portal vein thrombosis treated with thrombolytic therapy in a patient with ulcerative colitis in acute phase and to review the literature on thrombolytic therapy of mesenteric-portal system. Treatment of acute portal vein thrombosis has ranged from conservative treatment with thrombolysis and anticoagulation therapy to surgical treatment with thrombectomy and/or intestinal resection.METHODS: We treated our patient with intraportal infusion of plasminogen activator and then heparin through a percutaneous transhepatic catheter.RESULTS: Thrombus resolved despite premature interruption of the thrombolytic treatment for neurological complications, which subsequently resolved.CONCLUSION: Conservative management with plasminogen activator, could be considered as a good treatment for patients with acute porto-mesenteric thrombosis. | Alfredo Guglielmi Francesca Fior Orsolya Halmos Gian Franco Veraldi Lorenzo Rossaro Andrea Ruzzenente Claudio Cordiano | 2005 | World Journal of Gastroenterology2005，11，13： | 3 |
| 13 | Intrahepatic Cholangiocarcinoma: Prognostic Factors After Surgical Resection显示文摘 | Alfredo Guglielmi Andrea Ruzzenente Tommaso Campagnaro Silvia Pachera Alessandro Valdegamberi Paola Nicoli Alessandro Cappellani Giulio Malfermoni Calogero Iacono | 2009 | World Journal of Surgery2009，，6： | 3 |
| 14 | Undernutrition, risk of malnutrition and obesity in gastroenterological patients: A multicenter study显示文摘AIM: To investigate the prevalence of undernutrition, risk of malnutrition and obesity in the Italian gastroenterological population. METHODS: The Italian Hospital Gastroenterology Association conducted an observational, cross-sectional multicenter study. Weight, weight loss, and body mass index were evaluated. Undernutrition was defined as unintentional weight loss > 10% in the last threesix months. Values of Malnutrition Universal Screening Tool(MUST) > 2, NRS-2002 > 3, and Mini Nutritional Assessment(MNA) from 17 to 25 identified risk of malnutrition in outpatients, inpatients and elderly patients, respectively. A body mass index ≥ 30 indicated obesity. Gastrointestinal pathologies were categorized into acute, chronic and neoplastic diseases. RESULTS: A total of 513 patients participated in the study. The prevalence of undernutrition was 4.6% in outpatients and 19.6% in inpatients. Moreover, undernutrition was present in 4.3% of the gastrointestinal patients with chronic disease, 11.0% of those with acute disease, and 17.6% of those with cancer. The risk of malnutrition increased progressively and significantly in chronic, acute and neoplastic gastrointestinal diseases in inpatients and the elderly population. Logistical regression analysis confirmed that cancer was a risk factor for undernutrition(OR = 2.7; 95%CI: 1.2-6.44, P = 0.02). Obesity and overweight were more frequent in outpatients. CONCLUSION: More than 63% of outpatients and 80% of inpatients in gastroenterological centers suffered from significant changes in body composition and required specific nutritional competence and treatment. | Massimiliano Rizzi Silvia Mazzuoli Nunzia Regano Rosa Inguaggiato Margherita Bianco Gioacchino Leandro Elisabetta Bugianesi Donatella Noè Nicoletta Orzes Paolo Pallini Maria Letizia Petroni Gianni Testino Francesco William Guglielmi | 2016 | World Journal of Gastrointestinal Oncology2016，8，7： | 2 |
| 15 | Radiofrequency Ablation Versus Surgical Resection for the Treatment of Hepatocellular Carcinoma in Cirrhosis显示文摘 | Alfredo Guglielmi Andrea Ruzzenente Alessandro Valdegamberi Silvia Pachera Tommaso Campagnaro Mirko D'Onofrio Enrico Martone Paola Nicoli Calogero Iacono | 2008 | Journal of Gastrointestinal Surgery2008，，1： | 2 |
| 16 | The Dagradi-Serio-Iacono Operation Central Pancreatectomy显示文摘 | Calogero Iacono Luca Bortolasi Enrico Facci Filippo Nifosì Silvia Pachera Andrea Ruzzenente Alfredo Guglielmi | 2007 | Journal of Gastrointestinal Surgery2007，，3： | 2 |
| 17 | Reoperations for acute prosthetic thrombosis and pannus: an assessment of rates, relationship and risk显示文摘 | G. Rizzoli C. Guglielmi G. Toscano V. Pistorio I. Vendramin T. Bottio G. Thiene D. Casarotto | 1999 | European Journal of Cardio-Thoracic Surgery1999，，1： | 2 |
| 18 | Kinetics of the deposition of inert particles from electrolytic baths显示文摘 | Guglielmi N | 1972 | Journal of the Electrochemical Society1972，119，8： | 1 |
| 19 | Intracranial aneurysms treated with the gugliemi detachable coil:midterm clinical results in a consecutive of 100 patients显示文摘 | Malisch T W Guglielmi G Vinucla F | 1997 | J Neurosurg1997，87，： | 1 |
| 20 | Endovascular treatment of posteri or circulation aneurysms by electrothrombosis using electrically detachable coils显示文摘 | Vinuela F | 1992 | J Neurosurg,1992，77，： | 1 |
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