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| 1 | Potential therapeutics specific to c-MET/RON receptor tyrosine kinases for molecular targeting in cancer therapy显示文摘遇见 c 的 proto-oncogenes 和 RON 的产品属于受体酷氨酸 kinases 的一个亚科显著地作出贡献到 tumorigenic 前进。在主要肿瘤,改变了调整被房间移植和矩阵侵略描绘的侵略生长的 c-MET/RON 表达式 transduces 信号。这些病原的特征为在癌症治疗指向 c-MET/RON 提供基础。在最后十年,各种各样的途径被调查了压制 c-MET/RON-transduced oncogenesis。在开发的治疗学之中, monoclonal 抗体(mAbs ) 和小分子的禁止者(SMI ) 作为有希望的候选人出现了。这些治疗学的候选人的机制是为幸存的 c-MET/RON 信号上的肿瘤相关性的混乱。对 hepatocyte 生长因素(AMG102 ) 特定、遇见 c 的 mAbs (MetMAb ) 是人性化并且能堵住遇见 c 的发信号,在异种皮移植在肿瘤生长的 vitro 和抑制导致肿瘤房间增长的抑制当模特儿。mAb AMG102 抵销 hepatocyte 生长因素并且在 vivo 提高各种各样的 chemotherapeutics 的 cytotoxicity 到肿瘤。AMG102 当前在为有先进稳固的肿瘤的病人的阶段 II 临床的试用。IMC-41A40 和 Zt/f2 是 RON 特定的 mAbs 那下面调整 RON 表情并且禁止导致 ligand 的 phosphorylation。两 mAbs 在老鼠禁止肿瘤生长由冒号和胰腺的癌症细胞调停了。对特定的 SMI 遇见 c (ARQ107 和 PF-02341066 ) 在临床的试用的各种各样的阶段。治疗学的功效也与象化合物那样的双禁止者被观察了我,它对 c-MET/RON 特定。然而,一个潜在的问题是到这些禁止者的获得的抵抗的出现。清楚地, c-MET/RON 治疗学的开发为以后与癌症作斗争提供机会和挑战。 | Ming-Hai WANG Snehal S PADHYE Sunny GUIN Qi MA Yong-qing ZHOU | 2010 | Acta Pharmacologica Sinica2010，31，9： | 10 |
| 2 | Magnetically separable Pd catalyst for highly selective epoxide hydrogenolysis under mild conditions 显示文摘 | Guin D Baruwati B Manorama S V | 2007 | Org Let2007，9，7： | 1 |
| 3 | Great expectation: dominance, breeding success and offspring sex ratio in red deer 显示文摘 | Clutton-Back T H Albon S D Guinness F E | 1986 | Anim Behav1986，34，： | 1 |
| 4 | D-penicillamine-induced autoimmunity in the brown Norway rat:role for both T and non-T splenocytes in adoptive transfer of tolerance显示文摘 | Séguin B Masson MJ Uetrecht J | 2004 | Chem Res Toxicol2004，17，10： | 1 |
| 5 | Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Aktl survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-inducedapoptosis显示文摘 | SHANKAR S L O'GUIN K KIM M | 2006 | J Neurosci2006，，： | 1 |
| 6 | Molecular characterizationand di erential mRNA tissue distribution of mouse apolipoprotein D显示文摘 | Séguin D Desforges M Rassart E | 1995 | Mol Brain Res1995，30，： | 1 |
| 7 | Survivin inhibition induces human neutral tumor cell death through caspaseindependent and caspase - dependent pathways 显示文摘 | Shankar SL Mani S O'Guin KN | 2001 | J Neurochem2001，79，： | 1 |
| 8 | Survivin inhibition induces human neural tumor cell death through caspase-independent and-dependent pathways显示文摘 | SHANKAR S L MANI S O'GUIN K N | 2001 | J Neurochem2001，79，2： | 1 |
| 9 | Study of the convective drying ofpumpkin(Cucurbita maxima)显示文摘 | GUINE R P F PINHO S BARROCAET M J | 2011 | Food Bioprod Process2011，89，4： | 1 |
| 10 | Maternal dominance, breeding success and offspring sex ratios in red deer 显示文摘 | Clutton-Back T H Albon S D Guinness F E | 1984 | Anim Behav1984，34，： | 1 |
| 11 | KOH and NaOH activation mechanisms of multiwalled carbon nanotubes with different structural organization显示文摘 | Raymundo-Pi(n)ero E Aza(i)s P Cacciaguerra T Cazorla-Amorós D Linares-Solano A Béguin F | | 0，，04： | 1 |
| 12 | Synthesis ofpolyesters containing disiloxane subunits:Structural characterization,kinetics,and an examination of the thermal tolerance ofNovozym-435显示文摘 | Frampton M B Séguin J P Marquardt D | 2013 | Journal of Molecular Catalysis B:Enzymatic2013，85，14： | 1 |
| 13 | A tabu search heuristic for the vehicle routing problem with stochastic demands and customers显示文摘 | Gendreau M Laporte G Séguin R | 1996 | Operations Research1996，44，3： | 1 |
| 14 | Users'perspectives on the benefits of FM systems with cochlear implants显示文摘 | Fitzpatrick EM Fournier P Séguin C | 2010 | Int J Audiol2010，49，： | 1 |
| 15 | Effects of disease modifying anti-rheumatic drugs on subclinical atherosclerosis and endothelial dysfunction which has been detected in early rheumatoid arthritis:1-year follow-up study显示文摘 | Guin A Chatterjee AM Chakraborty S | | 0，，13： | 1 |
| 16 | Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Aktl survival pathway to protect oligodendrocytes from tumor necrosis factor alpha- induced apoptosis 显示文摘 | Shankar S L O' Guin K Kim M | 2006 | J Neurosci2006，26，： | 1 |
| 17 | Development and validation of a rapid real-time PCR based method for the specific detection of Salmonella on fresh meat 显示文摘 | Mc Guinness S McCabe e 0' Regan E | 2009 | Meat Sci2009，83，3： | 1 |
| 18 | The MTS assay as an indicator of chemosen sitivity/resistance in malignant gynaecological tumors显示文摘 | TOOLE S A SHEPPARD B L GUINNESS E P | 2003 | Cancer Detect Prev2003，27，1： | 1 |
| 19 | Evi dence of Torque teno virus (TTV) vertical transmission in swine显示文摘 | MARTINEZ GUIN L KEKARAINEN T SEGAL S J | 2009 | Theriogenology2009，71，9： | 1 |
| 20 | Activity of noble metal- promoted hydropmeessing catalysts for pyridine HDN and naphthalene hydrogenation 显示文摘 | Joo H S Guin James A | 1996 | Fuel Process Tectmol1996，49，： | 1 |
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