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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | 激活β_3肾上腺素能受体恢复一氧化氮/氧化还原平衡,增强高血糖患者的内皮功能显示文摘一氧化氮与O_2^-之间的平衡紊乱(即一氧化氮/氧化还原失衡)是糖尿病引起的血管功能障碍的中心病理环节。该研究目的为在高血糖动物模型中探索β_3肾上腺素能受体(β_3adrenergic receptor,β3AR)激活能否耦合激活内皮型一氧化氮合酶(endothelial nitric oxide synthase,eNOS)。 | 刘莉 叶鹏 Karimi Galougahi K Liu CC Garcia A Gentile C Fry NA Hamilton EJ Hawkins CL Figtree GA | 2016 | 中华高血压杂志2016，24，3： | 2 |
| 3 | Proportionate incresease of fibrinogen and albumin synthesis in nephritic patients:Measurements with stable isotopes显示文摘 | De Sain-van der Velden MGM Kaysen GA De Meek K et la | 1998 | Kidney Int1998，53，1： | 2 |
| 4 | Hydrogen storage characteristics of Ti 2 Ni alloy synthesized by the electro-deoxidation technique显示文摘 | Mustafa Anik Bedri Baksan Tu?ba ?l?er Orbay Nilüfer Kü?ükdeveci Alanur Binal Aybar Re?at Can ?zden Hakan Ga?an Nur?en Ko? | 2014 | Intermetallics2014，，： | 2 |
| 5 | A functional classification scheme for β-lactamases and its correlation with molecular structure显示文摘 | Bush K Jacoby GA Medeiros AA | 1995 | Antimicrob Agents Chemother1995，39，6： | 1 |
| 6 | Id proteins are dynamically expressed in normal epidermis and dysregulated in squamous cell carcinoma显示文摘 | Langlands K Down GA Kealey T | 2000 | Cancer Res2000，60，21： | 1 |
| 7 | Insulin receptor substratc-1 gene mutations in NIDDM :implications for the study of poiygenic disease 显示文摘 | Hitman GA Hawrami K McCarthy MI | 1995 | Diabetoiogia1995，38，4： | 1 |
| 8 | Glucose induce beta-cell apoptosis via upregulation of the Fas receptor in human islets显示文摘 | Maedler K Spinas GA Lehmann R Sergeev P Weber M Fontana A | 2001 | Diabetes2001，50，8： | 1 |
| 9 | A functional classification scheme for β-lactamases and its correlation with molecular structure 显示文摘 | Bush K Jacoby GA Medeiros AA | 1995 | Antimicrob Agents Clemother1995，39，6： | 1 |
| 10 | Mutations in a new gene encoding a thiamine transporter cause thiamine-responsive megaloblastic anaemia syndrome显示文摘 | Diaz GA Banikazemi M Oishi K | 1999 | Nat Genet1999，22，3： | 1 |
| 11 | A functional classification scheme for B-lactamase and its correlation with molecular structure显示文摘 | Bush K Jscky GA Medeiros A | 1995 | Antimicrob Agents Chemother1995，39，： | 1 |
| 12 | computed tomography image - guided surgery in complex acetabular fractures 显示文摘 | Broun GA Willis MC Firoozbakhsh K | 2000 | clim Orthop2000，370，1： | 1 |
| 13 | Photodynamic therapy of experimental choroidal neo- vascularization with a hydrophilic photosensitizer: mono-L-asp- artyl chlorine e6 显示文摘 | Mori K Yoneya S Anzail K Kabasawa S Sodeyama T Peyman GA et a/ | 2001 | Retina2001，21，5： | 1 |
| 14 | Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage显示文摘 | Cortes J Wiesmann K Roberts GA | 1995 | Science1995，268，5216： | 1 |
| 15 | Legislative mandates for use of active surveillance cultures to screen for methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci:position statement from the Joint SHEA and APIC Task Force显示文摘 | Weber SG Huang SS Oriola S W.Huskins C Noskin GA Harriman K | | American Journal of Infection Control0，，： | 1 |
| 16 | Rapid prototyping: the future of trauma surgery?显示文摘 | Brown GA Firoozbakhsh K DeCoster TA | 2003 | J Bone Joint Surg Am2003，85，： | 1 |
| 17 | Novel cationic cholesterol derivative-based liposomes for serum-enhanced delivery of siRNA 显示文摘 | Su EH Hyungu K Ga YS | 2008 | Int J Pharm2008，353，12： | 1 |
| 18 | Noise-induced hearingloss in young adults:the role of personal listening devices and othersouces of leisure noise显示文摘 | Mostafapour SP Lahargoue K Gates GA | 1998 | Laryngoscope1998，108，12： | 1 |
| 19 | A functional classification scheme for β - lactamases and its correlation with molecular structure 显示文摘 | Bush K Jacoby GA Medeiros AA | 1995 | Antimicrob Agents Chemother1995，39，： | 1 |
| 20 | Oral immunization with recombinant Helicobacter pylori urease confers long-lasting immunity against Helicobacter felis infection显示文摘 | Myers GA Ermak TH Georgakopoulos K | 1999 | Vaccine1999，17，1112： | 1 |
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