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| 1 | Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats显示文摘瞄准:决定 melatonin 预告的处理的效果并且在 L 精氨酸(L-Arg ) 的严厉上处理以后在老鼠的导致的试验性的胰腺炎。方法:男 Wistar 老鼠(25 ) 被划分成五个组。那些在 1h 的间隔在组 A 收到了 3.2g/kg 体重 L-Arg i.p 的二注射。在组麻省,老鼠与 50 mg/kg 体重 melatonin i.p 被对待在 L-Arg 管理以前的 30 min。在组 AM,在 L-Arg 被给以后,老鼠收到了 melatonin 1h 的一样的剂量。在组 M, melatonin 的单次量是以前描述了被管理。在组 C,对照动物收到了生理盐水注射 i.p 所有老鼠被给在第二 L-Arg 注射以后的 24 h。结果:引起严重引起坏死胰腺炎的 L-Arg 管理在浆液淀粉酶水平,胰腺的重量 / 身体重量比率(pw/bw ) ,胰腺的 IL-6 内容和 myeloperoxidase 由重要举起证实了活动,相对控制值。浆液淀粉酶水平的举起显著地在与仅仅与 L-Arg 注射的老鼠相比给 melatonin 追随者 L-Arg 的老鼠被减少。胰腺的抗氧化剂酶(Cu/Zn-superoxide 歧化酶(Cu/Zn-SOD ) 和过氧化氢酶(猫)) 的活动显著地被增加在胰腺炎以后的 24 h 感应。显著地在 L-Arg 之前给的 Melatonin 在独自与 L-Arg 对待的老鼠相对那减少了胰腺的猫活动。在肝, L-Arg 显著地每氧化水平,和谷胱甘肽过氧化物酶和 Cu/Zn-SOD 活动增加了类脂化合物,而 Mn 草皮活动作为与控制老鼠相比被减少。Melatonin 预告的处理阻止了这些变化。结论:Melatonin 是能在尖锐胰腺炎期间抵抗一些 L-Arg-induced 变化的一种抗氧化剂,并且可能因此在有尖锐引起坏死胰腺炎的病人的支持的治疗有用。 | Annamaria Szabolcs Russel J Reiter Tamas Letoha Peter Hegyi Gabor Papai Ilona Varga Katalin Jarmay Jozsef Kaszaki Reka Sari Zoltan Rakonczay Jr Janos Lonovics Tamas Takacs | 2006 | World Journal of Gastroenterology2006，12，2： | 13 |
| 2 | Elevated miR-33a and miR-224 in steatotic chronic hepatitis Cliver biopsies显示文摘AIM:To assess the expression of selected microRNAs(miRNA) in hepatitis C,steatotic hepatitis C,noninfected steatotic and normal liver tissues.METHODS:The relative expression levels of miR-21,miR-33 a,miR-96,miR-122,miR-125 b,miR-221 and miR-224 were determined in 76 RNA samples isolated from 18 non-steatotic and 28 steatotic chronic hepatitis C(CHC and CHC-Steatosis,respectively) cases,18 non-infected,steatotic liver biopsies of metabolic origin(Steatosis) and 12 normal formalin-fixed paraffin-embedded liver tissues using TaqMan MicroRNA Assays.All CHC biopsy samples were obtained prior to initiating therapy.Patients' serum biochemical values,which included glucose,triglyceride,cholesterol,alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma-glutamyl-transferase(GGT),alkaline phosphatase(AP),were obtained and correlated with relative miRNA expression.RESULTS:When compared with control non-infected liver samples,miR-122 and miR-221 levels were reduced in CHC-Steatosis(P < 0.03) and in CHC,CHCSteatosis and Steatosis(P < 0.01).Alternatively,the expression of miR-33 a and miR-224 were elevated in CHC-Steatosis and Steatosis in comparison to control tissue(P < 0.01).The levels of miR-33 a and miR-224 in CHC-Steatosis(P < 0.02) and miR-224 in Steatosis(P < 0.001) were increased in comparison to CHC samples.By contrast,the expression of miR-21 did not differ statistically between diseased and normal liver samples.Levels of miR-33 a correlated negatively with serum AST and AP levels in Steatosis as well as with necroinflammatory grade in CHC,whereas miR-21 correlated positively with AST in Steatosis and displayed negative correlation with triglyceride level in CHC-Steatosis.In contrast,miRNA levels were not correlated with ALT,GGT,cholesterol levels or fibrosis stage.CONCLUSION:Differences in miRNA expression were observed between CHC and steatotic CHC,CHC and steatotic liver,but not between steatotic CHC and steatotic liver of metabolic origin. | Gabor Lendvai Katalin Jármay Gizella Karácsony Tünde Halász Ilona Kovalszky Kornélia Baghy Tibor Wittmann Zsuzsa Schaff András Kiss | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 3 | Efficient recovery of envi- ronmental DNA for expression cloning by indirect extraction meth- ods显示文摘 | Gabor E M de Vries E J Janssen D B | 2003 | FEMS Microbiol Ecol2003，44，2： | 1 |
| 4 | High-efficiency CuInxGa1-xSe2 solar cells made from (InxGa1-x)2Se3 precursor film 显示文摘 | GABOR A M TUTTLE J R ALBIN D S | 1994 | Appl Phys Lett1994，62，： | 1 |
| 5 | Price as an indicator of quality: report on an inquiry 显示文摘 | GABOR A GRANGER C W J 1966 | 1966 | Economica1966，33，： | 1 |
| 6 | Synthesis and structural characterization of bioactive peptide conjugates using thioether linkage approaches显示文摘 | Gabor M Marilena M Annam A J | 2004 | J Peptide Sci2004，10，5： | 1 |
| 7 | Automated seizure detection using a self-organizing neural network显示文摘 | GABOR A J LEACH R R DOWLA F U | 1996 | Electroen- cephalogr Clin Neurophysiol1996，99，3： | 1 |
| 8 | Comparison of depositional sequences and tectonic styles among the West African deep- water frontiers of western Ivory Coast,southern Equatorial Guinea and northern Namibia显示文摘 | Katrina C Gabor C T Molnar J | 2002 | The Leading Edge2002，10，： | 1 |
| 9 | Automated seizure detection using a self-organising neural network 显示文摘 | Gabor A J Leach RR Dowla FU | 1996 | Electroenceph Clin Neurophysiol1996，99，： | 1 |
| 10 | An approximation algorithm for a facility location problem with stochastic demands and inventories 显示文摘 | GABOR A OMMEREN J | 2006 | Operations Res Lett2006，34，3： | 1 |
| 11 | 查看详情显示文摘 | Gabor N M Song J Ma Q Nair N L Taychatanapat T Watanabe K Taniguchi T Levitov L S Jarillo-Herrero P | | 0，，： | 1 |
| 12 | Prevalence of metabolic syndrome,insulin resistance,and microvascular angina pectoris in 500consecutive patients referred to coronarography显示文摘 | Hrnciar J Avdicova M Gabor D | 2013 | Endocr Regul2013，47，1： | 1 |
| 13 | Band-gap engineering in Cu(In,Ga)Se2 thin films grown from (In,Ga)2Se3 precursors显示文摘 | Gabor A M Tuttle J R Bode M H | 1996 | Sol Energy Mater & Sol Cells1996，4142，： | 1 |
| 14 | Cellulose Pyrolysis Kinetics: The Current States of Knowledge 显示文摘 | Jerry A M J Gabor V | 1995 | Industrial and Engineering Chemistry Research1995，34，3： | 1 |
| 15 | Construction,characterization,and use of small-insert gene banks of DNA isolated from soil and enrichment cultures for the recovery of novel amidases显示文摘 | Gabor E M de Vries E J Janssen D B | 2004 | Environ Microbiol2004，6，9： | 1 |
| 16 | High-efficien- cy Culn, Gal- ,Se2 solar cells made from ( In,, Gal )2Se3 precursor films显示文摘 | Gabor A M Tuttle J R Albin D S | 1994 | Applied Physics Letters1994，65，2： | 1 |
| 17 | Cyclic stress-strain response and low-cycle fatigue damage in ultrafine grained copper显示文摘 | MAIER H J GABOR P KARAMAN I | | 0，，： | 1 |
| 18 | Impact of nocturnalhemodialysis on the variability of heart rate and duration ofhypoxemia during sleep 显示文摘 | CHAN C T HANLY P GABOR J | 2004 | Kidney Int2004，65，2： | 1 |
| 19 | High-efflciency CuInxGa1-xSe2 solar cells made from (Inx, Ga1-x )2 Se3 precursorfilms显示文摘 | Gabor A M Tuttle J R Albin D S | 1994 | Applied Physics Letters1994，，65： | 1 |
| 20 | Efficient recovery of environmental DNA for expression cloning by indirect extraction methods显示文摘 | Gabor E M de Vries E J Janssen D B | 2003 | Microbiol Ecol2003，44，2： | 1 |
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