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| 1 | Prognostic significance of vascular endothelial growth factor polymorphisms in colorectal cancer patients显示文摘AIM To investigate the associations of the genetic polymor-phisms of vascular endothelial growth factor A(VEGF-A)-1498C>T and-634G>C, with the survival of patients with colorectal cancer(CRC). METHODS A prospective cohort consisting of 131 Brazilians patients consecutively operated on with a curative intention as a result of sporadic colorectal carcinoma was studied. DNA was extracted from peripheral blood and its amplification and allelic discrimination for each genetic polymorphism was performed using the technique of polymerase chain reaction(PCR) in real-time. The real-time PCR technique was used to identify the VEGF-A-1498C>T(rs833031) and-634G>C(rs2010963) polymorphisms. Genotyping was validated for VEGF-A-1498C>T polymorphism in 129 patients and for VEGF-A-634G>C polymorphism in 118 patients. The analysis of association between categorical variables was performed using logistic regression, survival by Kaplan-Meier method and multivariate analysis by the Cox regression method. RESULTS In the univariate analysis there was a significant association(OR = 0.32; P = 0.048) between genotype CC of the VEGF-A-1498C>T polymorphism and the presence of CRC liver metastasis. There was no association between VEGF-A-1498C>T polymorphism and VEGF-A-634G>C polymorphism with further clinical or anatomopathologic variables. The genotype CC of the VEGF-A-1498C>T polymorphism was significantly correlated with the 5-year survival(P = 0.032), but not significant difference(P = 0.27) was obtained with the VEGF-A-634G>C polymorphism with the 5-year survival in the univariate analysis. The genotype CT(HR = 2.79) and CC(HR = 4.67) of the polymorphism VEGF-A-1498C>T and the genotype CC(HR = 3.76) of the polymorphism VEGF-A-634C>G acted as an independent prognostic factor for the risk of death in CRC patients. CONCLUSION The CT and CC genotypes of the VEGF-A-1498C>T and the CC genotype of the VEGF-A-634C>G polymorphisms are prognostic factors of survival in Brazilians patients with sporadic colorectal carcinoma. | Gilmar Ferreira do Espírito Santo Bianca Borsatto Galera Elisabeth Carmen Duarte Elisabeth Suchi Chen Lenuce Azis Amilcar Sabino Damazo Gabriela Tognini Saba Flávia de Sousa Gehrke Ismael Dale Cotrim Guerreiro da Silva Jaques Waisberg | 2017 | World Journal of Gastrointestinal Oncology2017，9，2： | 4 |
| 2 | HLA B27 as Predisposition Factor to Suffer Age Related Macular Degeneration显示文摘研究是否特定的等位基因 HLA 一级(HLA -- A 和 HLA-B ) 并且班 II (HLA 医生) 是风险因素因为年龄的 exudative 类型的发展联系了有斑点的退化(ARMD ) , HLA 抗原与 ARMD 在正常、影响的眼睛两个都被表示。我们设计了未来的控制盒子的研究。我们与主要经典或秘密的 choroidal neovascularization 招募了 75 个病人,对 ARMD 第二等,并且与光力学的治疗对待。超过 55 岁的 250 个病人,没有 ophthalmologic 病理,为分析平淡的检查去了医院的人,被用作控制。数据的分析显示出二个组之间的重要差别。等位基因 HLA-B27 与 ARMD 断然相关(p < 0.0113 ) 。然而,我们没发现等位基因否定地联系了。因此 HLA-B27 是等位基因预先安排承受 ARMD。 | Enrique Villegas Becerril Rafael Gonzalez Fernandez Luis Perula Torres Manuel Santos Lacomba Jose Maria Gallardo Galera | 2009 | Cellular & Molecular Immunology2009，6，4： | 2 |
| 3 | Deterruination of photoirradiated high polar benzoylureas in tomato by HPLC with luminol chemiluminescence detection显示文摘 | Martinez Galera M Gil Gareia M D Santiago Valverde R | 2008 | Talanta2008，76，4： | 1 |
| 4 | Transforming growth factor beta(TGF-beta)and articular chondrocytes显示文摘 | Pujol JP Galera P Pronost S | 1999 | Ann Endocrinol Paris1999，55，2： | 1 |
| 5 | Changing medical ICU environmental and the impact on nosocomial in- fection 显示文摘 | Fahed GP Galera A Torres-Palacios A etal | 2007 | Crit Care Shock2007，10，1： | 1 |
| 6 | Specific flavonoids promote intercellular root colonization of Arabidopsis thaliana by Azorhizobium caulinodans ORS571 显示文摘 | Gough C Galera C Vasse J | 1997 | Mol Plant Microbe Interact1997，，10： | 1 |
| 7 | Industrial Marketing Applications of Quan- tum Measurement Techniques显示文摘 | Alvarez P Galera C | 2001 | Industrial Marketing Manage- ment2001，30，1： | 1 |
| 8 | Chemometric assisted solid-phase microextraction for the determination of anti-inflammatory and antiepileptic drugs in river water by liquid chromatography-diode array detection显示文摘 | Candioti LV Garcia MDG Galera MM | 2008 | J Chromatogr A2008，1211，： | 1 |
| 9 | Transforming growth factor β stimulates collagen and glycosaminoglycan biosynthesis in cultured rabbit articular chondrocytes显示文摘 | Redi TI Galera P Mauviel A | 1988 | FEBs letters1988，234，： | 1 |
| 10 | Determination of benzoylureas in tomato by high-performance liquid chromatography using continuous on-line post-elution photoirradiation with fluorescence detection 显示文摘 | MARTINEZ - GALERA M LOPEZ - LOPEZ T GIL - GARCIA M D | 2001 | JChromatogr: A2001，918，1： | 1 |
| 11 | Transforming growth factor β stimulates collagen and glycosam inoglycan biosynthesis in cultured rabbit articular chondrocytes 显示文摘 | Redi TI Galera P Mauviel A | 1988 | FEBS Lett1988，234，1： | 1 |
| 12 | Determination of carbendazim,thiabendazole and fuberidazole using a net analyte signal-based method 显示文摘 | Galera M M Zamora D P Vidal J L M | 2003 | Talanta2003，59，6： | 1 |
| 13 | Determination of cypermethrin, fenvalerate and cis-andtrans-permethrin in soil and ground water by high-performance liquid chromatography using partial least-squares regression显示文摘 | Galera M Vidal J L M | 1996 | J Chromatography A1996，727，： | 1 |
| 14 | Exercise oxygen flow titration methods in COPD patients with respiratory failure 显示文摘 | Galera R Casitas R Martinez E | 2012 | Respir med2012，106，11： | 1 |
| 15 | New method for the photo-chemiluminometric determination of benzoylurea insecticides based on acetonitrile chemiluminescence 显示文摘 | Garcia M Galera M Valverde R | 2007 | Anal Bioanal Chem2007，387，6： | 1 |
| 16 | Under- standing factors influencing consumer attitudes toward cause - related marketing显示文摘 | Galan Ladero M M Galera Casquet C Singh J | 2015 | International Journal of Nonprofit and Vol- untary Sector Marketing2015，20，1： | 1 |
| 17 | Clearance rates and aquifer- ous systems in two sponges with contrasting life-history strategies 显示文摘 | TURON X GALERA J URIZ M J | 1997 | Journal of Experimental Zoology1997，78，： | 1 |
| 18 | Solid-phase microextraction (SPME) for the determination of pyrethroids in cucumber and watermelon using liquid chromatography combined with postcolumn photochemically induced fluorimetry derivatization and fluorescence detection显示文摘 | VAZQUEZ P P MUGHARI A R GALERA M M | 2008 | Analytica Chimica Acta2008，607，： | 1 |
| 19 | Determination of nine pyrethroid insecticides by high-performance liquid chromatography with post-column photoderivatization and detection based on acetonitrile chemiluminescenee显示文摘 | Galera M M Garcia M D G Valverde R S | 2006 | J Chromatogr A2006，1113，： | 1 |
| 20 | Comparison of plasmatic steroid levels with and without previous oral contractive administration in GnRH antagonist IVF cycles显示文摘 | Galera F Verdu V Billaf(n)ez V | 2004 | Fertil Steril2004，822，： | 1 |
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