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| 1 | Post reperfusion syndrome during liver transplantation:From pathophysiology to therapy and preventive strategies显示文摘This review aims at evaluating the existing evidence regarding post reperfusion syndrome, providing a description of the pathophysiologic mechanisms involved and possible management and preventive strategies. A Pub Med search was conducted using the Me SH database, 'Reperfusion' AND 'liver transplantation' were the combined Me SH headings; EMBASE and the Cochrane library were also searched using the same terms. 52 relevant studies and one ongoing trial were found. The concept of post reperfusion syndrome has evolved through years to a multisystemic disorder. The implications of the main organ, recipient and procedure related factors in the genesis of this complex syndrome are discussed in the text as the novel pharmacologic and technical approaches to reduce its incidence. However the available evidence about risk factors, physiopathology and preventive measures is still confusing, the presence of two main definitions and the numerosity of possible confounding factors greatly complicates the interpretation of the studies. | Antonio Siniscalchi Lorenzo Gamberini Cristiana Laici Tommaso Bardi Giorgio Ercolani Laura Lorenzini Stefano Faenza | 2016 | World Journal of Gastroenterology2016，22，4： | 20 |
| 2 | Role of epidural anesthesia in a fast track liver resection protocol for cirrhotic patients-results after three years of practice显示文摘AIM To evaluate the potential benefits and risks of the use of epidural anaesthesia within an enhanced recovery protocol in this specific subpopulation.METHODS A retrospective review was conducted, including all cirrhotic patients who underwent open liver resection between January 2013 and December 2015 at Bologna University Hospital. Patients with an abnormal coagulation profile contraindicating the placement of an epidural catheter were excluded from the analysis. The control group was composed by patients refusing epidural anaesthesia. RESULTS Of the 183 cirrhotic patients undergoing open liver resections, 57 had contraindications to the placement of an epidural catheter; of the remaining 126, 86 patients received general anaesthesia and 40 combined anaesthesia. The two groups presented homogeneous characteristics. Intraoperatively the metabolic data did not differ between the two groups, whilst the epidural group had a lower mean arterial pressure(P = 0.041) and received more colloid infusions(P = 0.007). Postoperative liver and kidney function did not differ significantly.Length of mechanical ventilation(P = 0.003) and hospital stay(P = 0.032) were significantly lower in the epidural group. No complications related to the epidural catheter placement or removal was recorded.CONCLUSION The use of Epidural Anaesthesia within a fast track protocol for cirrhotic patients undergoing liver resections had a positive impact on the patient's outcomes and comfort as demonstrated by a significantly lower length of mechanical ventilation and hospital stay in the epidural group. The technique appears to be safely manageable in this fragile population even though these results need confirmation in larger studies. | Antonio Siniscalchi Lorenzo Gamberini Tommaso Bardi Cristiana Laici Elisa Gamberini Letizia Francorsi Stefano Faenza | 2016 | World Journal of Hepatology2016，8，26： | 13 |
| 3 | Ventilator associated pneumonia following liver transplantation:Etiology,risk factors and outcome显示文摘AIM: To determine the incidence, etiology, risk factors and outcome of ventilator-associated pneumonia(VAP) in patients undergoing orthotopic liver transplantation(OLT).METHODS: This retrospective study considered 242 patients undergoing deceased donor OLT. VAP was diagnosed according to clinical and microbiological criteria. RESULTS: VAP occurred in 18(7.4%) patients, with an incidence of 10 per 1000 d of mechanical ventilation(MV). Isolated bacterial etiologic agents were mainly Enterobacteriaceae(79%). Univariate logistic analysis showed that model for end-stage liver disease(MELD) score, pre-operative hospitalization, treatment with terlipressin, Child-Turcotte-Pugh score, days of MV and red cell transfusion were risk factors for VAP. Multivariateanalysis, considering significant risk factors in univariate analysis, demonstrated that pneumonia was strongly associated with terlipressin usage, pre-operative hospitalization, days of MV and red cell transfusion. Mortality rate was 22% in the VAP group vs 4% in the group without VAP. CONCLUSION: Our data suggest that VAP is an important cause of nosocomial infection during postoperative period in OLT patients. MELD score was a significant risk factor in univariate analysis. Multiple transfusions, treatment with terlipressin, preoperative hospitalization rather than called to the hospital while at home and days of MV constitute important risk factors for VAP development. | Antonio Siniscalchi Lucia Aurini Beatrice Benini Lorenzo Gamberini Stefano Nava Pierluigi Viale Stefano Faenza | 2016 | World Journal of Transplantation2016，6，2： | 9 |
| 4 | Thoracic epidural anesthesia:Effects on splanchnic circulation and implications in Anesthesia and Intensive care显示文摘AIM: To evaluate the currently available evidence on thoracic epidural anesthesia effects on splanchnic macro and microcirculation, in physiologic and pathologic conditions.METHODS:A Pub Med search was conducted using the Me SH database.Anesthesia,Epidural was always the first MeS H heading and was combined by boolean operator AND with the following headings:Circulation,Splanchnic;Intestines;Pancreas and Pancreatitis;LiverFunction Tests.EMBASE,Cochrane library,ClinicalT rials.gov and clinicaltrialsregister.eu were also searched using the same terms.RESULTS:Twenty-seven relevant studies and four ongoing trials were found.The data regarding the effects of epidural anesthesia on splanchnic perfusion are conflicting.The studies focusing on regional macro-hemodynamics in healthy animals and humans undergoing elective surgery,demonstrated no influence or worsening of regional perfusion in patients receiving thoracic epidural anesthesia(TEA).On the other hand most of the studies focusing on micro-hemodynamics,especially in pathologic low flow conditions,suggested that TEA could foster microcirculation.CONCLUSION:The available studies in this field are heterogeneous and the results conflicting,thus it is difficult to draw decisive conclusions.However there is increasing evidence deriving from animal studies,that thoracic epidural blockade could have an important role in modifying tissue microperfusion and protecting microcirculatory weak units from ischemic damage,regardless of the effects on macro-hemodynamics. | Antonio Siniscalchi Lorenzo Gamberini Cristiana Laici Tommaso Bardi Stefano Faenza | 2015 | World Journal of Critical Care Medicine2015，4，1： | 8 |
| 5 | Hypogonadism,diabetes mellitus,hypothyroidism,hypoparathyroidism:incidence and prevalence related to iron overload and chelation therapy in patients with thalassaemia major followed from 1980 to 2007 in the Ferrara Centre显示文摘 | Gamberini MR De Sanctis V Gilli G | 2008 | Pediatr Endocrinol Rev2008，6，1： | 1 |
| 6 | Detection of slime production by means of an optimised Congo red agar plate test based on a colourimetric scale in Staphylococcus epidermidis clinical isolates genotyped for ica locus 显示文摘 | Arciola CR Campoccia D Gamberini S | 2002 | Biomaterials2002，23，21： | 1 |
| 7 | A new multiobjective heuristic algorithm for solving the stochastic assembly line re-balancing problem显示文摘 | Gamberini R Grassi A Riminia B | 2006 | International Journal of Production Economics2006，102，2： | 1 |
| 8 | A multiple single-pass heuristic algorithm solving the stochastic assembly line rebalancing problem显示文摘 | Gamberini R Gebennini E Grassi A | 2009 | International Journal of Production Research2009，47，8： | 1 |
| 9 | A multiple single-pass heuristic algorithm solving the stochastic assembly line rebalancing problem显示文摘 | Gamberini R Gebennini E Grassi A | 2009 | International Journal of Production Research2009，47，8： | 1 |
| 10 | Immunohistochemical expression of internal and external ErbB-2 domains in invasive breast cancer显示文摘 | Ceccarelli C Santini D Gamberini M | 1999 | Breast Cancer Res Treat1999，58，： | 1 |
| 11 | A fuzzy multi-attribute model for risk evaluation in workplaces显示文摘 | Grassi A Gamberini R Mora C | 2009 | Safety Science2009，47，5： | 1 |
| 12 | Detection of slime production by means of an optimised Congo red agar plate test based on a colourimetric scale in Staphylococcus epidermidis clinical isolates genotyped for ica locus显示文摘 | Arciola CR Campocda D Gamberini S | 2002 | Biomaterials2002，23，： | 1 |
| 13 | Nitrophenyl derivatives as aldose reductase inhibitors显示文摘 | Costanfino L Ferrari AM Gamberini MC et ol | 2002 | Bioorg Med Chem2002，10，12： | 1 |
| 14 | Effi- cacy of low-close human chorionic gonadotropin alone to com- plete controlled ovarian stimulation显示文摘 | FILICORI M COGNIGNI G E GAMBERINI E | 2005 | Fertility and Sterility2005，84，2： | 1 |
| 15 | A fuzzy multi-attribute model for risk evaluation in workplaces显示文摘 | ANDREA GRASSI RITA GAMBERINI CRISTINA MORA | 2009 | Safety Science2009，47，5： | 1 |
| 16 | Detection of slime production by means of an optimized Congo red agar plate test based on a colourimetric scale in Staphylococcus epidermidis clinical isolates genotyped for ica locus显示文摘 | Arciola CR Campoccia D Gamberini S | 2002 | Biomaterials2002，4，23： | 1 |
| 17 | Modifiable and nonmodifiable risk factors for postoperative delirium after cardiac surgery with cardiopulmonary bypass 显示文摘 | Burkhart CS Del]-Kuster S Gamberini M etal | 2010 | J Cardiothorac Vasc Anesth2010，24，4： | 1 |
| 18 | A new multiobjective heuristic algorithm for solving the stochastic assembly line rebalancingproblem显示文摘 | Gamberini R Grassi A Riminia B | 2006 | International Journal of Production Economics2006，102，： | 1 |
| 19 | A fuzzy mult-i attributemodel for risk evaluation in workplaces显示文摘 | GRASSI A GAMBERINI R MORA C | 2009 | Safety Science2009，47，5： | 1 |
| 20 | Misoprostol for the treatment of chronic erosive gastritis:a double blind placebo control trial显示文摘 | Pazzi P Gamberini S Scagliarini R | 1994 | Am J Gastroenterol1994，89，7： | 1 |
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