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| 1 | Indo-Western Pacific Ocean Capacitor and Coherent Climate Anomalies in Post-ENSO Summer: A Review显示文摘ENSO induces coherent climate anomalies over the Indo-western Pacific, but these anomalies outlast SST anomalies of the equatorial Pacific by a season, with major effects on the Asian summer monsoon. This review provides historical accounts of major milestones and synthesizes recent advances in the endeavor to understand summer variability over the Indo-Northwest Pacific region. Specifically, a large-scale anomalous anticyclone(AAC) is a recurrent pattern in post-El Ni ?no summers, spanning the tropical Northwest Pacific and North Indian oceans. Regarding the ocean memory that anchors the summer AAC, competing hypotheses emphasize either SST cooling in the easterly trade wind regime of the Northwest Pacific or SST warming in the westerly monsoon regime of the North Indian Ocean. Our synthesis reveals a coupled ocean–atmosphere mode that builds on both mechanisms in a two-stage evolution. In spring, when the northeast trades prevail, the AAC and Northwest Pacific cooling are coupled via wind–evaporation–SST feedback. The Northwest Pacific cooling persists to trigger a summer feedback that arises from the interaction of the AAC and North Indian Ocean warming, enabled by the westerly monsoon wind regime. This Indo-western Pacific ocean capacitor(IPOC) effect explains why El Ni ?no stages its last act over the monsoonal Indo-Northwest Pacific and casts the Indian Ocean warming and AAC in leading roles. The IPOC displays interdecadal modulations by the ENSO variance cycle, significantly correlated with ENSO at the turn of the 20 th century and after the 1970 s, but not in between. Outstanding issues, including future climate projections, are also discussed. | Shang-Ping XIE Yu KOSAKA Yan DU Kaiming HU Jasti S.CHOWDARY Gang HUANG | 2016 | Advances in Atmospheric Sciences2016，33，4： | 75 |
| 2 | Cold-chain food contamination as the possible origin of COVID-19 resurgence in Beijing显示文摘COVID-19,caused by SARS-CoV-2[1,2],has been contained in China through stringent non-pharmaceutical interventions.Border control and quarantine have effectively prevented the virus from being spread by infected travellers,but the risk of resurgence caused by other routes of introduction and transmission remains unclear,and current strategies to prevent resurgence could be flawed.Since July,SARS-CoV-2 RNA contaminations in frozen food imported from countries with ongoing epidemics have been reported in nine provinces in China[3,4].However,there is no robust evidence of COVID-19 outbreaks initiated by environmentto-human transmission.Here we add to evidence of such transmission by investigating the recent COVID-19 resurgence in Beijing. | Xinghuo Pang Lili Ren Shuangsheng Wu Wentai Ma Jian Yang Lin Di Jie Li Yan Xiao Lu Kang Shichang Du Jing Du Jing Wang Gang Li Shuguang Zhai Lijuan Chen Wenxiong Zhou Shengjie Lai Lei Gao Yang Pan Quanyi Wang Mingkun Li Jianbin Wang Yanyi Huang Jianwei Wang COVID-19 Field Response Group COVID-19 Laboratory Testing Group | 2020 | National Science Review2020，7，12： | 51 |
| 3 | The intracellular mechanism of alpha-fetoprotein promoting the proliferation of NIH 3T3 cells显示文摘AIM The existence and properties of alpha-fetoprotein (AFP) receptor on the surface of NIH 3T3 cells and the effects of AFP on cellular signal transduction pathway were investigated. METHODS The effect of AFP on the proliferation of NIH 3T3 cells was measured by incorporation of 3H-TdR. Receptor-binding assay of 125I-AFP was performed to detect the properties of AFP receptor in NIH 3T3 cells. The influences of AFP on the [cAMP]i and the activities of protein kinase A (PKA) were determined. Western blot was used to detect the change of K-ras P21 protein expression. RESULTS The proliferation of NIH 3T3 cells treated with 0-80 mg/L of AFP was significantly enhanced. The Scatchard analysis indicated that there were two classes of binding sites with KD of 2.722×10-9M (Bmax=12810 sites per cell) and 8.931× 10-SM (Bmax=l19700 sites per cell) respectively. In the presence of AFP (20 mg/L), the content of cAMP and activities of PKA were significantly elevated . The level of K-ras P21 protein was upregulated by AFP at the concentration of 20 mg/L. The monoclonal antibody against AFP could reverse the effects of AFP on the cAMP content, PKA activity and the expression of K-ras p21 gene. CONCLUSION The effect of AFP on the cell proliferation was achieved by binding its receptor to trigger the signal transduction pathway of cAMP-PKA and alter the expression of K- ras p21 gene. | MENG SEN LI, PING FENG LI, FBI YI YANG, SHI PENG HE, Guo GUANG DU, GANG LI1 Department of Biochemistry and Molecular Biology, 2 Department of Biophysics, Health Science Center, Peking University, Beijing 100083, China | 2002 | Cell Research2002，12，2： | 27 |
| 4 | Analysis of variabilities of serum proteomic spectra in patients with gastric cancer before and after operation显示文摘瞄准:为了在手术前后与胃的癌症在病人学习浆液 proteomic 系列的可变性以便检测特定的蛋白质标记,那能被用于胃的癌症的快诊断。方法:从有在操作前后的胃的癌症的病人的 46 件浆液样品的 Proteomic 系列并且 40 被 IMAC-Cu 蛋白质薄片和飞行团分光术的提高表面的激光 desorption/ 电离时间从正常个人产生。结果:十四差别在浆液表示了蛋白质被外科手术前的病人和正常个人的 proteomic 系列的分析屏蔽。我们获得了 4 蛋白质(热吃惊蛋白质 27,调整葡萄糖的蛋白质,禁止在,蛋白质二硫化物异构酶 A3 ) 完成对班有能力的标记模式耐心队、正常队。这些标记模式分别地产出 95.7% 敏感和 92.5% 特性。在外科手术前的病人的浆液过去表示的蛋白质显然是下面调整的。结论:胃的癌症的特定的蛋白质标记能被用于胃的癌症的快诊断和预后的判断。SELDI-TOF-MS 是为在浆液的新蛋白质标记的察觉和鉴定的一个有用工具。 | Hong Ren Ning Du Gang Liu Heng-Tong Hu Wei Tian Zhi-Ping Deng Jing-Sen Shi | 2006 | World Journal of Gastroenterology2006，12，17： | 25 |
| 5 | Fibroblast growth factor 21 as a possible endogenous factor inhibits apoptosis in cardiac endothelial cells显示文摘(FGF21 ) 背景成纤维细胞生长因素 21 是是为全身的葡萄糖和类脂化合物新陈代谢的一个重要内长的管理者的 FGF 超级家庭的一个新成员。这研究试图探索 FGF21 是否减少动脉粥样硬化患者损害并且作为独立保护 factor.Methods 阻止 endothelial 机能障碍现在的学习被设计调查氧化低的密度脂蛋白(ox-LDL ) 导致的 FGF21 层次的变化,并且 apoptosis 的变化由调整 FGF21 表示影响了。有教养的心脏的 microvascular endothelial 房间(CMEC ) 的 FGF21 mRNA 层次被真实 time-PCR 决定,在文化媒介的蛋白质集中被连接酶的 immunosorbent 试金检测。我们分析了与 ox-LDL 孵化的未经治疗的控制和 CMFC 的不同表示层次,并且 CMEC apoptosis 的变化由分泌物 FGF21 mRNA 铺平的 FGF21 levels.Results 的改进或抑制开始了,蛋白质是显著地,在 CMEC 的 upregulated 与 ox-LDL 孵化了。而且, 200 mol/L bezafibrate 增加的 FGF21 层次能减少 CMEC apoptosis ,并且由导致的 shRNA 禁止 FGF21 表示 apoptosis ( P 0.05 ) .Conclusions FGF21 可以是受伤目标织物的一个信号,并且可以在在动脉粥样硬化并且在停止冠的心疾病的开发的一个早阶段改进 endothelial 函数起生理的作用。 | Lv Yun LIU Jing-hua ZHANG Li-ke DU Jie ZENG Xiang-jun HAO Gang HUANG Ji ZHAO Dong-hui WANG Guo-zhong ZHANG Ying-chuan | 2010 | Chinese Medical Journal2010，，23： | 25 |
| 6 | Effect of local wound infiltration with ropivacaine on postoperative pain relief and stress response reduction after open hepatectomy显示文摘AIM To prospectively evaluate the effect of local wound infiltration with ropivacaine on postoperative pain relief and stress response reduction after open hepatectomy.METHODS A total of 56 patients undergoing open hepatectomy were randomly divided into two groups:a ropivacaine group(wound infiltration with ropivacaine solution)and a control group(infiltration with isotonic saline solution).A visual analog scale(VAS)at rest and on movement was used to measure postoperative pain for the first 48 h after surgery.Mean arterial pressure(MAP),heart rate(HR),time to bowel recovery,length of hospitalization after surgery,cumulative sufentanil consumption,and incidence of nausea and vomiting were compared between the two groups.Surgical stress hormones(epinephrine,norepinephrine,and cortisol)were detected using enzyme-linked immunosorbent assay,and the results were compared. RESULTS VAS scores both at rest and on movement at 24 h and48 h were similar between the two groups.Significantly lower VAS scores were detected at 0,6,and 12 h in the ropivacaine group compared with the control group(P<0.05 for all).MAP was significantly lower at 6,12,and 24 h(P<0.05 for all);HR was significantly lower at 0,6,12,and 24 h(P<0.05 for all);time to bowel recovery and length of hospitalization after surgery(P<0.05 for both)were significantly shortened;and cumulative sufentanil consumption was significantly lower at 6,12,24,and 36 h(P<0.05 for all)in the ropivacaine group than in the control group,although the incidence of nausea and vomiting showed no significant difference between the two groups.The levels of epinephrine,norepinephrine,and cortisol were significantly lower in the ropivacaine group than in the control group at 24 and 48 h(P<0.01 for all). CONCLUSION Local wound infiltration with ropivacaine after open hepatectomy can improve postoperative pain relief,reduce surgical stress response,and accelerate postoperative recovery. | Jing-Xian Sun Ke-Yun Bai Yan-Feng Liu Gang Du Zhi-Hao Fu Hao Zhang Jin-Huan Yang Ben Wang Xiu-Yu Wang Bin Jin | 2017 | World Journal of Gastroenterology2017，23，36： | 25 |
| 7 | Mechanism of action of gypenosides on type 2 diabetes and non-alcoholic fatty liver disease in rats显示文摘AIM:To explore the mechanism of action of gypenosides(GPs)on type 2 diabetes mellitus and non-alcoholic fatty liver disease(T2DM-NAFLD)in rats.METHODS:Sixty rats were randomly divided into a healthy group,an untreated disease model group andGP-treatment groups.The study involved the evaluation of biochemical parameters,including serum aspartate transaminase(AST),alanine transferase(ALT),blood glucose(BG),triglycerides(TG)and total cholesterol(TC).Additionally,the protective effect of the treatments were confirmed histopathologically and the expression of TNF-αand NF-κB in the rat liver was analyzed using immunohistochemistry.The expression of proliferatoractivated receptor gamma(PPARγ)and cytochrome P450(CYP450)1A1 m RNA was determined by quantitative RTPCR.RESULTS:GP treatments at oral doses of 200,400,and800 mg/kg per day significantly decreased the levels of serum AST and ALT(P<0.05,P<0.01),especially at the dose of 800 mg/kg per day.To a similar extent,GP at800 mg/kg per day reduced the levels of BG(4.19±0.47,P<0.01),TG(80.08±10.05,P<0.01),TC(134.38±16.39,P<0.01)and serum insulin(42.01±5.04,P<0.01).The expression of TNF-αand NF-κB measured by immunohistochemistry was significantly reduced by GPs in a dose-dependent manner,and the expression of PPARγand CYP4501A1 m RNA,as measured using quantitative real-time PCR,were significantly down-regulated by GPs.Moreover,GPs decreased the infiltration of liver fats and reversed the histopathological changes in a dosedependent manner.CONCLUSION:This study suggests that GPs have a protective effect against T2DM-NAFLD by down-regulating the expression of TNF-αand NF-κB proteins,and PPARγand CYP4501A1 m RNAs. | Qin He Jin-Ke Li Fang Li Ru-Gui Li Guo-Qing Zhan Gang Li Wei-Xing Du Hua-Bing Tan | 2015 | World Journal of Gastroenterology2015，21，7： | 22 |
| 8 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 9 | Anus-preserving rectectomy via telescopic colorectal mucosal anastomosis for low rectal cancer: Experience from a Chinese cohort显示文摘AIM: To investigate the safety and efficacy of anus-preserving rectectomy via telescopic colorectal mucosal anastomosis (TCMA) for low rectal cancer. METHODS: From August 1993 to October 2012, 420 patients including 253 males and 167 females with low rectal cancer underwent transabdominal and transanal anterior resection, followed by TCMA. The distance be-tween the anus and inferior margin of the tumor ranged from 5 to 7 cm, and was 5 cm in 6 patients, 6 cm in 127, and 7 cm in 287 patients. Tumor-node-metastasis staging showed that 136 patients had stage Ⅰ, 252 had stage Ⅱ and 32 had stage Ⅲ. Fifty-six patients with T3 or over received preoperative neoadjuvant chemoradio-therapy. RESULTS: The postoperative follow-up rate was 91.9% (386/420) with a median time of 6.4 years. All 420 pa-tients underwent radical resection. No postoperativedeath occurred. Postoperative complications included anastomotic leakage in 13 (3.1%) patients and anas-tomotic stenosis in 7 (1.6%). The local recurrence rate after surgery was 6.2%, the hepatic metastasis rate was 13.2% and the pulmonary metastasis rate was 2.3%. The 5-year survival rate was 74.0% and the disease-free survival rate was 71.0%. Kirwan classification showed that continence was good in 94.4% of patients with stage I when scored 12 mo after resection. CONCLUSION: TCMA for patients with low rectal cancer leads to better quality of life and satisfactory defecation function, and lowers anastomotic leakage occurrence, and might be one of the safe operative procedures in anus-preserving rectectomy. | Shi-Yong Li Gang Chen Xue Bai Fu-Yi Zuo Guang Chen Jun-Feng Du Xiao-Jun Wei Wei Cui | 2013 | World Journal of Gastroenterology2013，19，24： | 19 |
| 10 | Laparoscopic resection of lower rectal cancer with telescopic anastomosis without abdominal incisions显示文摘AIM:To assess laparoscopic radical resection of lower rectal cancer with telescopic anastomosis through transanal resection without abdominal incisions.METHODS:From March 2010 to June 2014, 30 patients(14 men and 16 women, aged 36-78 years, mean age 59.8 years) underwent laparoscopic radical resection of lower rectal cancer with telescopic anastomosis through anus-preserving transanal resection.The tumors were 5-7 cm away from the anal margin in 24 cases, and 4 cm in six cases.In preoperative assessment, there were 21 cases of T1N0M0 and nine of T2N0M0.Through the middle approach, the sigmoid mesentery was freed at the root with an ultrasonic scalpel and the roots of the inferior mesenteric artery and vein were dissected, clamped and cut.Following the total mesorectal excision principle, the rectum was separated until the anorectal ring reached 3-5 cm from the distal end of the tumor.For perineal surgery, a ring incision was made 2 cm above the dentate line, and sharp dissection was performed submucosally towards the superior direction, until the plane of the levator ani muscle, to transect the rectum.The rectum and distal sigmoid colon were removed together from the anus, followed by a telescopic anastomosis between the full thickness of the proximal colon and the mucosa and submucosal tissue of the rectum.RESULTS:For the present cohort of 30 cases,the mean operative time was 178 min,with an average of 13 positive lymph nodes detected.One case of postoperative anastomotic leak was observed,requiring temporary colostomy,which was closed and recovered3 mo later.The postoperative pathology showed T1-T2N0M0 in 19 cases and T2N1M0 in 11 cases.Twelve months after surgery,94.4%patients achieved anal function Kirwan grade 1,indicating that their analfunction returned to normal.The patients were followed up for 1-36 mo,with an average of 23 mo.There was no local recurrence,and 17 patients survived for>3years(with a survival rate of 100%).CONCLUSION:Laparoscopic radical resection of lower rectal cancer with telescopic anastomosis through transanal resection without abdominal incisions is safe and feasible. | Shi-Yong Li Gang Chen Jun-Feng Du Guang Chen Xiao-Jun Wei Wei Cui Fu-Yi Zuo Bo Yu Xing Dong Xi-Qing Ji Qiang Yuan | 2015 | World Journal of Gastroenterology2015，21，16： | 19 |
| 11 | Experimental investigation of the generation of large-amplitude internal solitary wave and its interaction with a submerged slender body显示文摘A principle of generating the nonlinear large-amplitude internal wave in a stratified fluid tank with large cross-section is proposed according to the‘jalousie’control mode.A new wave-maker based on the principle was manufactured and the experiments on the generation and evolution of internal solitary wave were conducted.Both the validity of the new device and applicability range of the KdV-type internal soliton theory were tested.Furthermore,a measurement technique of hydrodynamic load of internal waves was developed.By means of accurately measuring slight variations of internal wave forces exerted on a slender body in the tank,their interaction characteristics were determined.It is shown that through establishing the similarity between the model scale in the stratified fluid tank and the full scale in the numerical simulation the obtained measurement results of internal wave forces are confirmed to be correct. | WEI Gang DU Hui XU XiaoHui ZHANG YuanMing QU ZiYun HU TianQun YOU YunXiang | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，2： | 17 |
| 12 | Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein显示文摘Background:Abnormal aggregation of brainα-synuclein is a central step in the pathogenesis of Parkinson’s disease(PD),thus,it is reliable to promote the clearance ofα-synuclein to prevent and treat PD.Recent studies have revealed an essential role of glymphatic system and meningeal lymphatic vessels in the clearance of brain macromolecules,however,their pathophysiological aspects remain elusive.Method:Meningeal lymphatic drainage of 18-week-old A53T mice was blocked via ligating the deep cervical lymph nodes.Six weeks later,glymphatic functions and PD-like phenotypes were systemically analyzed.Results:Glymphatic influx of cerebrospinal fluid tracer was reduced in A53T mice,accompanied with perivascular aggregation ofα-synuclein and impaired polarization of aquaporin 4 expression in substantia nigra.Cervical lymphatic ligation aggravated glymphatic dysfunction of A53T mice,causing more severe accumulation ofα-synuclein,glial activation,inflammation,dopaminergic neuronal loss and motor deficits.Conclusion:The results suggest that brain lymphatic clearance dysfunction may be an aggravating factor in PD pathology. | Wenyan Zou Tinglin Pu Weixi Feng Ming Lu Ying Zheng Renhong Du Ming Xiao Gang Hu | 2019 | Translational Neurodegeneration2019，8，1： | 17 |
| 13 | An R2R3-type transcription factor gene AtMYB59 regulates root growth and cell cycle progression in Arabidopsis显示文摘MYB 蛋白质在真核细胞的有机体起重要作用。在植物, R1R2R3 类型 MYB 蛋白质在房间周期控制工作。然而, R2R3 类型 MYB 蛋白质是否也涉及房间部门过程,仍然保持未知。这里,我们报导那 R2R3 类型抄写因素基因, AtMYB59,涉及房间周期前进和根生长的规定。AtMYB59 蛋白质在洋葱的原子核是局部性的表皮的房间并且 transactivation 活动。在酵母房间的 AtMYB59 的表示压制房间增长,和 transformants 与更长的房间有更多的原子核和更高的 aneuploid DNA 内容。在 AtMYB59 的保存领域的变化在酵母细胞生长上废除它的效果。在同步 Arabidopsis 房间暂停, AtMYB59 基因明确地在房间周期前进期间在 S 阶段被表示。表示和 promoter-GUS 分析表明 AtMYB59 基因富有地在根被表示。转基因的植物 overexpressing AtMYB59 更短的根与野类型的植物(Arabidopsis 就职 Col-0 ) 相比,并且在在根尖端的有丝分裂的房间的一半附近在中期。相反地,空变异的 myb59-1 比关口在中期让更长的根和更少有丝分裂的房间,建议那 AtMYB59 可以由扩大有丝分裂的房间的中期禁止根生长。AtMYB59 调整许多下游的基因,包括 CYCB1; 1 基因,可能通过到 MYB 应答的元素的绑定。这些结果在细胞周期规定和植物根生长为 AtMYB59 支持一个角色。 | Rui-Ling Mu Yang-Rong Cao Yun-Feng Liu Gang Lei Hong-Feng Zou Yong Liao Hui-Wen Wang Wan-Ke Zhang Biao Ma Ji-Zhou Du Ming Yuan Jin-Song Zhang Shou-Yi Chen | 2009 | Cell Research2009，19，11： | 16 |
| 14 | Laboratory simulation on acoustic well-logging with phased array transmitter显示文摘Two small scale acoustic phased arrays with 4 elements have been designed and assembled in the laboratory. Experiments have been carried out with them. It is found that both directivity and radiation lobe width of the phased array can be regulated by changing the time delay between the input signals on neighboring elements. Results measured are in good agreement with those calculated. By using the phased array as an acoustic transmitter and hydrophone as a receiver, small scale acoustic well-logging simulations have been carried out both on an aluminum model well and on a concrete one. Experimental results show that, by increasing the time delay of the input signals on neighboring elements, the steered radiation angle of the phased array becomes larger and larger, and generation conditions of the refracted compressional wave and the refracted shear wave are reached successively, and the refracted compressional wave, the refracted shear wave and the Stoneley wave axe strengthened, respectively. Therefore, by choosing element spacing of a phased array and acoustic wave frequency appropriately, the main radiation lobe of the phased array can be widened to cover the first critical angle of all kinds of formations, which makes it possible to apply phased array acoustic well-logging in any formation continuously without regulating directivity of the phased array. | QIAO Wenxiao CHEN Xuelian DU Guangsheng FANG Jun LI Gang(Faculty of Natural Resources and Information Technology, University of Petroleum Beijing 102249) | 2003 | Chinese Journal of Acoustics2003，22，4： | 14 |
| 15 | A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population显示文摘Objective: To evaluate the efficacy and safety of salvianolate in elderly patients with unstable angina pectoris(UAP). Methods: A prospective double-blind randomized placebo-controlled multicenter trial in elderly patients with UAP from 13 third-grade class-A hospitals in China was performed. A total of 318 patients were randomly allocated in a 1:1 ratio to an experimental group(160 patients) and a control group(158 patients). The experimental group was treated with salvianolate for 14 days on the basis of conventional medicine, and the control group was given a placebo for 14 days with the same criteria. Follow-up was lasted 28 days in both groups. The primary endpoint was biweekly frequency of angina pectoris attacks. The secondary endpoints included biweekly dosage of nitroglycerin, the Seattle Angina Questionnaire, angina pectoris severity and duration, myocardial injury markers, high-sensitivity C-reactive protein(hs-CRP) and N-terminal pro-B-type natriuretic peptide(NT-proBNP), as well as major adverse cardiovascular events(MACEs). Safety was assessed according to adverse events and serious adverse events. Results: Baseline characteristics were similar between treatment groups. Compared with those in the control group, the frequency of biweekly angi na attacks(2.92 vs. 4.08, P =0.025), th e biweekly dosage of nitroglycerin, as well as the severity and duration of angina attacks(P <0.01) were reduced by salvianolate. The Seattle Angina Questionnaire score was also significantly improved in the experimental group than in the control group(P <0.05). No significant differences were observed between the two groups with respect to the incidence of MACEs. Salvianolate was well tolerated. Conclusions: Salvianolate appear to have efficacy and well tolerated for elderly patients with UAP. | CUI Hua LI Xiao-ying GAO Xue-wen LU Xiang WU Xiu-ping WANG Xiao-fei ZHENG Xiang-qing HUANG Kui LIU Feng LUO Zhi YUAN Hui-shu SUN Gang KONG Jian DU Xiao-hong ZHENG Jin LIU Hong-ying ZHANG Wen-ju | 2019 | Chinese Journal of Integrative Medicine2019，25，10： | 13 |
| 16 | Overlay of a sponge soaked with ropivacaine and multisite infiltration analgesia result in faster recovery after laparoscopic hepatectomy显示文摘BACKGROUND Compared with traditional open surgery,laparoscopic surgery is preferred due to the advantages of less trauma,less pain,and faster recovery.Nevertheless,many patients still suffer from postoperative pain resulting from the surgical incision and associated tissue injury.Many researchers have reported methods to improve postoperative pain control,but there is not a simple and effective method that can be clinically adopted in a widespread manner.We designed this study to prove the hypothesis that application of ropivacaine in the port site and operative site in patients is an effective and convenient method which can decrease postoperative pain and accelerate recovery.AIM To evaluate the effects of ropivacaine on pain control after laparoscopic hepatectomy and its contribution to patient recovery.METHODS From May 2017 to November 2018,146 patients undergoing laparoscopic hepatectomy were randomized to receive infiltration of either 7.5 mg/mL ropivacaine around the trocar insertions,incision,and cutting surface of the liver(with a gelatin sponge soaked with ropivacaine)at the end of surgery(ropivacaine group),or normal saline(5 mL)at the same sites at the end of surgery(control group).The degree of pain,nausea,vomiting,heart rate(HR),and blood pressure were collected.The length of postoperative hospitalization,complications,and the levels of stress hormones were also compared between the two groups.RESULTS Compared with the control group,the ropivacaine group showed reduced postoperative pain at rest within 12 h(P<0.05),and pain on movement was reduced within 48 h.The levels of epinephrine,norepinephrine,and cortisol at 24 and 48 h,HR,blood pressure,and cumulative sufentanil consumption in the ropivacaine group were significantly lower than those in the control group(P<0.05).In the ropivacaine group,hospitalization after operation was shorter,but the difference was not statistically significant.There were no significant differences in postoperative nausea,vomiting,or other complications,including hydrothorax,ascites,peritonitis,flatulence,and venous thrombus(P>0.05),although fewer patients in the ropivacaine group experienced these situations.CONCLUSION Infiltration with ropivacaine in the abdominal wound and covering the cutting surface of the liver with a gelatin sponge soaked with ropivacaine significantly reduce postoperative pain and the consumption of sufentanil. | Hao Zhang Gang Du Yan-Feng Liu Jin-Huan Yang Mu-Guo A-Niu Xiang-Yu Zhai Bin Jin | 2019 | World Journal of Gastroenterology2019，25，34： | 13 |
| 17 | PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins显示文摘Mutations in RNA-binding proteins (RBPs) localized in ribonucleoprotein (RNP) granules, such as hnRNP A1 and TDP-43, promote aberrant protein aggregation, which is a pathological hallmark of various neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Protein posttranslational modifications (PTMs) are known to 佗gulate RNP granules. In this study, we investigate the function of poly(ADP-ribosyl)ation (PARylation), an important PTM involved in DNA damage repair and cell death, in RNP granule-related neurodegeneration. We reveal that PARylation levels are a major regulator of the assembly-disassembly dynamics of RNP granules containing disease-related RBPs, hnRNP A1 and TDP-43. We find that hnRNP A1 can both be PARylated and bind to PARylated proteins or poly(ADP-ribose)(PAR). We further uncover that PARylation of hnRNP A1 at K298 controls its nucleocytoplasmic transport, whereas PAR-binding via the PAR-binding motif (PBM) of hnRNP Al regulates its association with stress granules. Moreover, we reveal that PAR not only dramatically enhances the liquid-liquid phase separation of hnRNP A1, but also promotes the co-phase separation of hnRNP A1 and TDP-43 in vitro and their interaction in vivo. Finally, both genetic and pharmacological inhibition of PARP mitigates hnRNP Al- and TDP-43-mediated neurotoxicity in cell and Drosophila models of ALS. Together, our findings suggest a novel and crucial role for PARylation in regulating the dynamics of RNP granules, and that dysregulation in PARylation and PAR levels may con tribute to ALS disease pathoge nesis by promoting protei n aggregation. | Yongjia Duan Aiying Du Jinge Gu Gang Duan Chen Wang Xinrui Gui Zhiwei Ma Beituo Qian Xue Deng Kai Zhang Le Sun Kuili Tian Yaoyang Zhang Hong Jiang Cong Liu Yanshan Fang | 2019 | Cell Research2019，29，3： | 13 |
| 18 | Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)显示文摘Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence.Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology.The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. | Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-Ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu | 2022 | Military Medical Research2022，9，4： | 13 |
| 19 | Re-Os dating of gold-bearing arsenopyrite of the Maoling gold deposit,Liaoning Province,Northeast China and its geological significance显示文摘The Maoling gold deposit, one of the large gold deposits in eastern Liaoning Province, NE China, is an ar- senopyrite-disseminated gold deposit with a resource of ap- proximately 25 t Au and an average Au grade of 3.2 g/t. Six arsenopyrites closely related to Au mineralization of the Maoling gold deposit are dated by Re-Os technique and de- fine a Re-Os isochron with an age of 2316±140 Ma, which suggests that the deposit was formed in the Paleoproterozoic era rather than in the Indosinian period as some early re- searchers suggested. High initial 187Os/188Os ratio of 1.32±0.48 indicates a crustal derivation of the ore-forming material of the deposit, which may be derived from rocks of the Gaixian formation of the Liaohe Group. Furthermore, the result also implies that the age of the Gaixian Formation in the Maoling district is older than 2316±140 Ma. | YU Gang YANG Gang CHEN Jiangfeng QU Wenjun DU Andao HE Wei | 2005 | Chinese Science Bulletin2005，50，14： | 12 |
| 20 | Optimum design of hierarchical stiffened shells for low imperfection sensitivity显示文摘A concept of hierarchical stiffened shell is proposed in this study,aiming at reducing the imperfection sensitivity without adding additional weight.Hierarchical stiffened shell is composed of major stiffeners and minor stiffeners,and the minor stiffeners are generally distributed between adjacent major stiffeners.For various types of geometric imperfections,e.g.,eigenmode-shape imperfections,hierarchical stiffened shell shows significantly low imperfection sensitivity compared to traditional stiffened shell.Furthermore,a surrogate-based optimization framework is proposed to search for the hierarchical optimum design.Then,two optimum designs based on two different optimization objectives(including the critical buckling load and the weighted sum of collapse loads of geometrically imperfect shells with small-and large-amplitude imperfections)are compared and discussed in detail.The illustrative example demonstrates the inherent superiority of hierarchical stiffened shells in resisting imperfections and the effectiveness of the proposed framework.Moreover,the decrease of imperfection sensitivity can finally be converted into a decrease of structural weight,which is particularly important in the development of large-diameter launch vehicles. | Bo Wang Peng Hao Gang Li Jia-Xin Zhang Kai-Fan Du Kuo Tian Xiao-Jun Wang Xiao-Han Tang | 2014 | Acta Mechanica Sinica2014，30，3： | 12 |
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