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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Role of extracellular matrix components in facial nerve regeneration: an experimental study 显示文摘 | Donzelli R Maiuri F Piscopo GA | 2006 | Neurol Res2006，28，8： | 1 |
| 3 | Blood pressure and the progression of car - otid atherosclerosis in middle aged men 显示文摘 | Lakka TA Salonen R Kaplan GA | 1999 | Hypertension1999，34，1： | 1 |
| 4 | Epidemiology, presentation, and management of retroperitoneal leiomyomata: systematic literature review and case report显示文摘 | Poliquin V Victory R Vilos GA | 2008 | J Minim Invasive Gynecol2008，15，2： | 1 |
| 5 | Claudin-3 and claudin-4 expression in serous papillary,clear-cell,and endometrioid endometrial cancer显示文摘 | Konecny GE Agarwal R Keeney GA | 2008 | Gynecol Oncol2008，109，2： | 1 |
| 6 | Glucose induce beta-cell apoptosis via upregulation of the Fas receptor in human islets显示文摘 | Maedler K Spinas GA Lehmann R Sergeev P Weber M Fontana A | 2001 | Diabetes2001，50，8： | 1 |
| 7 | Patient self-management of acute asthma:adherence to national guidelines a decade later显示文摘 | Scarfone R J Zocr J J Capraro GA | 2001 | Pediatrics2001，108，6： | 1 |
| 8 | In vitro evaluation of cellular inhibitory potential of various antineoplastic drugs and dexamethasone 显示文摘 | Fiscella R Peyman GA Elvart J | 1985 | Ophthalmic Surg1985，16，4： | 1 |
| 9 | A network meta-analysis ofrandomized controlled trials of biologies for rheumatoid arthritis: aCochrane overview显示文摘 | Singh JA Christensen R Wells GA^ | 2009 | CMAJ2009，181，11： | 1 |
| 10 | Inflammation and diet- ary protein intake exert competing effects on serum albumin and creati- nine in hemodialysis patients 显示文摘 | Kaysen GA Chertow GM Adhikarla R | 2001 | Kidney Int2001，60，1： | 1 |
| 11 | Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1β via p38 mitogen-activated protein kinase显示文摘 | Tong L Prieto GA Kramár EA | | 0，，49： | 1 |
| 12 | Ultrasonography of the hip and lower extremity显示文摘 | Malanga GA Dentico R Halperin JS | | 0，，03： | 1 |
| 13 | Role of the inter- leukin 10 family of cytokines in patients with immune reconstitution inflammatory syndrome associated with HIV infection and tubercu- losis 显示文摘 | Tadokera R Wilkinson KA Meintjes GA | 2013 | J Infect Dis2013，207，7： | 1 |
| 14 | Use of anticitrullianted peptide and-PA33 antibodies in distinguish erosive arthritis in patients with systemic lupus erythematosus and rheumatoid arthritis显示文摘 | Mediwake R Isenberg DA Scbellekens GA | 2001 | Ann Rheum Dis2001，60，1： | 1 |
| 15 | Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS) 显示文摘 | Gbadegesin R Hinkes B G Hoskins B E Vlangos C N Heerin ga S F Liu J | 2008 | Nephrol Dial Transplant2008，23，： | 1 |
| 16 | MicroRNAs in cancer显示文摘 | Garzon R Calin GA Croce CM | 2009 | Annual Rew Med2009，60，： | 1 |
| 17 | Human cytomegalovirus-encoded chemokine receptor US28 promotes tumorigenesis显示文摘 | Maussang D Verzijl D van Walsum M Leurs R Holl J Pleskoff O Michel D van Dongen GA Smit MJ | 2006 | Proc Natl Acad Sci USA2006，103，13： | 1 |
| 18 | Triamicinolone acetonide as an aid to visualization of the vitreous and posterior hyaloid during pars plana vitrectomy显示文摘 | Peyman GA Cheema R Conmay MD | 2000 | Retina2000，20，： | 1 |
| 19 | The late complications of acute pancre- atitis: pancreatic swelling, cyst and abscess显示文摘 | KUNE GA KING R | 2001 | Med J Aust2001，28，1： | 1 |
| 20 | Involvement of DNA methylation in memory processing in the honey bee 显示文摘 | Lockett GA Helliwell P Maleszka R | 2010 | Neuroreport2010，21，12： | 1 |
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