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| 1 | Irritable bowel syndrome: A microbiome-gut-brain axis disorder?显示文摘Irritable bowel syndrome(IBS) is an extremely prevalent but poorly understood gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help diagnose the disorder and treatment options are limited to management of the symptoms. The concept of a dysregulated gut-brain axis has been adopted as a suitable model for the disorder. The gut microbiome may play an important role in the onset and exacerbation of symptoms in the disorder and has been extensively studied in this context. Although a causal role cannot yet be inferred from the clinical studies which have attempted to characterise the gut microbiota in IBS, they do confirm alterations in both community stability and diversity. Moreover, it has been reliably demonstrated that manipulation of the microbiota can influence the key symptoms, including abdominal pain and bowel habit, and other prominent features of IBS. A variety of strategies have been taken to study these interactions, including probiotics, antibiotics, faecal transplantations and the use of germ-free animals. There are clear mechanisms through which the microbiota can produce these effects, both humoral and neural. Taken together, these findings firmly establish the microbiota as a critical node in the gut-brain axis and one which is amenable to therapeutic interventions. | Paul J Kennedy John F Cryan Timothy G Dinan Gerard Clarke | 2014 | World Journal of Gastroenterology2014，20，39： | 20 |
| 2 | Imaging of bone metastasis: An update显示文摘Early detection of skeletal metastasis is critical for accurate staging and optimal treatment. This paper briefly reviews our current understanding of the biological mechanisms through which tumours metastasise to bone and describes the available imaging methods to diagnose bone metastasis and monitor response to treatment. Among the various imaging modalities currently available for imaging skeletal metastasis, hybrid techniques whichfuse morphological and functional data are the most sensitive and specific, and positron emission tomography(PET)/computed tomography and PET/magnetic resonance imaging will almost certainly continue to evolve and become increasingly important in this regard. | Gerard J O'Sullivan Fiona L Carty Carmel G Cronin | 2015 | World Journal of Radiology2015，7，8： | 10 |
| 3 | Effect of donor–recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis显示文摘 | Mary Eapen John P Klein Guillermo F Sanz Stephen Spellman Annalisa Ruggeri Claudio Anasetti Maria Brown Richard E Champlin Joan Garcia-Lopez Gareth Hattersely Gesine Koegler Mary J Laughlin Gerard Michel Samir K Nabhan Franklin O Smith Mary M Horowitz Eli | 2011 | Lancet Oncology2011，，13： | 2 |
| 4 | Seismic waves in stratified anisotropic media显示文摘 | Gerard J F Frazer L N | 1984 | Geophysical Journal of the Royal Astronomical Society1984，78，： | 1 |
| 5 | Hox gene expression in limbs:colinearity by opposite regulatory controls显示文摘 | Hcrault Y Beckers J Gerard M | 1999 | Dev Biol1999，208，： | 1 |
| 6 | Competition for limiting amounts of oxygen between nitrosomanas europaea and nitrobacteria winogradskyi grown in mixed continuous cultures显示文摘 | Laanbroek H J Gerards S | 1993 | Arch Microbiology1993，，159： | 1 |
| 7 | Application of an electronic nose to correlate with descriptive sensory analysis of aged cheddar cheese显示文摘 | DRAKEA M A GERARD P D KLEINHENZ J P | 2003 | Lebensm Wiss U Technol2003，36，： | 1 |
| 8 | Nonlinear acoustic echo cancellation based on volterra filters 显示文摘 | G Alexandre F Gerard L B J Regine | 2003 | IEEE Transactions on Speech and Audio Processing2003，11，6： | 1 |
| 9 | Glibenclamide pharmacokinetics in acarbose-treated type 2 diabetics显示文摘 | Gerard J Lefebvre PJ Luyckx AS | 1984 | Eur J Clin Pharmacol1984，27，2： | 1 |
| 10 | Seismic waves in stratified anisotropic media显示文摘 | Gerard J F Frazer L N | 1987 | Geophysical Journal of the Royal Astronomieal Society1987，91，： | 1 |
| 11 | Improved quantitation of minimal redidual disease in multiple myeloma using real-time polymerase chain reaction and plasmid-DNA complementarity determining region Ⅲ standards 显示文摘 | Gerard C J Olsson K Ramanathan R | 1998 | Cancer Res1998，17，： | 1 |
| 12 | Threonine and crude protein responses in broiler chicks显示文摘 | Kidd M T Gerard P D Heger J | 2001 | Animal Feed Science and Technology2001，94，： | 1 |
| 13 | Competition for limiting amounts of oxygen between nitrosomanas European and nitmbacteria wingogradsbyi grown in mixed continuous cultures 显示文摘 | Lannbroek H J Gerards S | 1993 | Arch Microbiology1993，159，： | 1 |
| 14 | High dose methotrexate based chemotherapy with deferred radiation for treatment of newly diagnosed primary central nervous system lymphoma显示文摘 | Gerard LM Imrie KR Mangel J | 2011 | Leuk Lymphoma2011，52，88： | 1 |
| 15 | Molecular dynamics simulation of or- ganic-inorganic copolymers based on methacryl-POSS and methyl methacrylate 显示文摘 | Bizet S Galy J Gerard J-F | 2006 | Polymer2006，47，24： | 1 |
| 16 | Influence ofPOSS structure on the fire retardant properties of epoxy hybridnetworks 显示文摘 | FRANCHINI E GALY J GERARD J F | 2009 | Polymer Degradation and Stability2009，94，10： | 1 |
| 17 | Un-certainty in traffic forecasts: literature review andnew results for The Netherlands 显示文摘 | GERARD J ANDREW D MARITS P | 2007 | Transporta-tion2007，34，4： | 1 |
| 18 | Alginate hydrogels as synthetic extraeellular matrix materials 显示文摘 | Jon A R Gerard M Mooney D J | 1999 | Biomaterials1999，20，： | 1 |
| 19 | Mechanisms of reduced and compensatory growth 显示文摘 | HORNICK J L VAN EENAEME C GERARD O | 2000 | Domestic Animal Endocrinology2000，19，： | 1 |
| 20 | Dual-signal Receiver structures for simultaneous reception of two BPSK modulated co-channel signals using signal cancellation 显示文摘 | JANSSEN GERARD J M | 1994 | Wireless Personal Communications1994，1，1： | 1 |
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