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| 1 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 2 | Retrospective analysis of old-age colitis in the Dutch inflammatory bowel disease population显示文摘AIM: To describe the characteristics of Dutch patients with chronic inflammatory bowel disease (IBD) first diagnosed above 60 years of age-a disease also known as old-age colitis (OAC) and to highlight a condition that has a similar appearance to IBD, namely segmen- tal colitis associated with diverticular disease (SCAD). METHODS: A retrospective longitudinal survey of patient demographic and clinical characteristics, disease characteristics, diagnostic methods, management and course of disease was performed. The median follow-up period was 10 years. RESULTS: Of a total of 1100 IBD patients attending the Department of Gastroenterology, 59 (5%) [median age 82 years (range 64-101); 25 male (42%)] were identified. These patients were diagnosed with ulcerative colitis (n = 37, 61%), Crohn’s disease (n = 14, 24%), and indeterminate colitis (n = 8, 15%). Remission was induced in 40 (68%) patients within a median interval of 6 mo (range 1-21) and immunosuppressive therapy was well tolerated. Histological evaluation based on many biopsy samples and the course of the disease led to other diagnosis, namely SCAD instead of IBD in five (8%) patients. CONCLUSION: OAC is not an infrequent problem for the gastroenterologist, and should be considered in the evaluation of older patients with clinical featuressuggestive of IBD. Extra awareness and extensive biopsy sampling are required in order to avoid an erroneous diagnosis purely based on histological mimicry of changes seen in SCAD, when diagnosing IBD in the presence of diverticulosis coli. | Muhammed Hadithi Marcel Cazemier Gerrit A Meijer Elisabeth Bloemena Richel J Felt-Bersma Chris J Mulder Stephan GM Meuwissen Amado Salvador Pea Adriaan A van Bodegraven | 2008 | World Journal of Gastroenterology2008，14，20： | 3 |
| 3 | Lack of microRNA‐101 causes E‐cadherin functional deregulation through EZH2 up‐regulation in intestinal gastric cancer显示文摘 | Joana Carvalho Nicole C van Grieken Patricia M Pereira Sónia Sousa Marianne Tijssen Tineke E Buffart Bego?a Diosdado Heike Grabsch Manuel AS Santos Gerrit Meijer Raquel Seruca Beatriz Carvalho Carla Oliveira | 2012 | J Pathol2012，，1： | 3 |
| 4 | Physiological increases in uncoupling protein 3 augment Fatty Acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells显示文摘 | Maclellan JD Gerrits MF Gowing A | 2005 | Diabetes2005，54，8： | 1 |
| 5 | Comparison of PriestleyTaylor and FAO56 PenmanMonthith for daily reference evapotranspiration estimation in Georgia 显示文摘 | Ayman A Suleiman Gerrit Hoogenboom | 2007 | Journal of Irrigation and Drainage Engineering2007，133，2： | 1 |
| 6 | A High-Tc 4-bit periodic threshold analog-to-digital converter显示文摘 | Gerrit J Gerritsma Martin A J | 1997 | IEEE Transaction on Applied Superconductivity1997，7，2： | 1 |
| 7 | Quantitation of bilobalide and ginkgolides A, B, C, and J by means of nuclear magnetic resonance spectroscopy 显示文摘 | Terise A Van Beek Gerrit P Lelyveld | 1998 | Phytochemical Analysis1998，4，： | 1 |
| 8 | Transformation of lily by Agrobacterium显示文摘 | Langeveld S A Gerrits M M Derked F L M | 1995 | Euphytica1995，85，： | 1 |
| 9 | Tectonic evolu- tion of the Eastern Mediterranean Basin and its significance for hydrocarbon prospectivity in the ultradeepwater of the Nile Delta 显示文摘 | Abdel aal A Barkooky A Gerrits M | 2000 | The Leading Edge2000，19，10： | 1 |
| 10 | Transformation of lily by grobacterium显示文摘 | LANGEVELD S A GERRITS M M DERKS F L M etal | 1995 | Euphytica1995，85，1： | 1 |
| 11 | Transformation of Lily by agrobacterium显示文摘 | Langeveld S A Gerrits M M Anton F L M | 1995 | Euphytica1995，85，： | 1 |
| 12 | Cyclic estradiol replacement attenuates stress-induced c-Fos expression in the PVN of ovariectomized rats显示文摘 | GERRITS M GROOT KARIJN A BEKKERING BF | 2005 | Brain Research Bulletin2005，67，： | 1 |
| 13 | Cheese flavour development by enzymatic conversions of peptides and amino acids显示文摘 | Gerrit S Annette V Eman A | 2000 | Food Research International2000，33，3： | 1 |
| 14 | Geneic transformation of lily 显示文摘 | LANGEVELD S A MARINOVA S GERRITS M M | 1997 | Acta Hort1997，430，： | 1 |
| 15 | Perspectives for Artificial Insemination and Genomics to Improve Global Swine Populations显示文摘 | Gerrits R J Lunney J K~lohnson L A | 2005 | Theriogenology2005，63，2： | 1 |
| 16 | Photochemical generation of highly destabilized vinyl cations : The effects of α- andβ-trifluoromethyl versus α- and β-methyl substituents 显示文摘 | Kaj V A Geerte B Gerrit L | 2005 | J Org Chem ( S0022 -3262 )2005，70，： | 1 |
| 17 | Methodolo- gies for simulating impacts of climate change on crop produc- tion显示文摘 | JEFFREY W W GERRIT H BRUCE A K | 2011 | Field Crops Research2011，124，： | 1 |
| 18 | Preparative isolation and separation procedure for Ginkgolides A,B,C,and J and Bilobalide显示文摘 | Teris A Vanbeek Gerrit P Lelyveld | 1997 | J Nat Prod1997，60，7： | 1 |
| 19 | Physio-logical increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells显示文摘 | MacLellan J D Gerrits M F Gowing A | 2005 | Diabetes2005，54，8： | 1 |
| 20 | Next steps for the grand cooperative driving challenge: ITS Events 显示文摘 | Lauer M Gerrits A | 2009 | IEEE Intelligent Transportation Sys- tems Magazine2009，1，4： | 1 |
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