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| 1 | Rubber band ligation for 750 cases of symptomatic hemorrhoids out of 2200 cases显示文摘AIM: To study the results for the treatment of symptomatic hemorrhoids using rubber band ligation (RBL) method. METHODS: A retrospective study for 750 patients who came to the colorectal unit from June, 1998 to September, 2006, data was retrieved from archived fi les. RBL was performed using the Mc Gown applicator on an outpatient basis. The patients were asked to return to out-patient clinic for follow up at 2 wk, 1 mo, 6 mo and through telephone call every 6 mo for 2 years). RESULTS: After RBL, 696 patients (92.8%) were cured with no difference in outcome for second or third degree hemorrhoids (P = 0.31). Symptomatic recurrence was detected in 11.04% after 2 years. A total of 52 patients (6.93%) had 77 complications from RBL which required no hospitalization. Complications were pain, rectal bleeding and vaso-vagal symptoms(4.13%, 4.13% and 1.33% of patients, respectively). At 1 mo there were a significant improvement in mean SF-36 scores over baseline in five items, while after 2 years there were improvement in all items over baseline, but not significant. No significant manometeric changes after band ligation. CONCLUSION: RBL is a simple, safe and effective method for treating symptomatic second and third degree hemorrhoids as an out patient procedure with signifi cant improvement in quality of life. RBL doesn't alter ano-rectal functions. | Ayman M El Nakeeb Amir A Fikry Waleed H Omar Elyamani M Fouda Tito A El Metwally Hosam E Ghazy Sabry A Badr Mohmed Y Abu Elkhar Salih M Elawady Hisham H Abd Elmoniam Waiel W Khafagy Mosaad M Morshed Ramadan E El Lithy Mohamed E Farid | 2008 | World Journal of Gastroenterology2008，14，42： | 24 |
| 2 | Updates in the pathophysiological mechanisms of Parkinson's disease: Emerging role of bone marrow mesenchymal stem cells显示文摘AIM: To explore the approaches exerted by mesenchymal stem cells(MSCs) to improve Parkinson's disease(PD) pathophysiology.METHODS: MSCs were harvested from bone marrowof femoral bones of male rats, grown and propagated in culture. Twenty four ovariectomized animals were classified into 3 groups: Group(1) was control, Groups(2) and(3) were subcutaneously administered with rotenone for 14 d after one month of ovariectomy for induction of PD. Then, Group(2) was left untreated, while Group(3) was treated with single intravenous dose of bone marrow derived MSCs(BM-MSCs). SRY gene was assessed by PCR in brain tissue of the female rats. Serum transforming growth factor beta-1(TGF-β1), monocyte chemoattractant protein-1(MCP-1) and brain derived neurotrophic factor(BDNF) levels were assayed by ELISA. Brain dopamine DA level was assayed fluorometrically, while brain tyrosine hydroxylase(TH) and nestin gene expression were detected by semi-quantitative real time PCR. Brain survivin expression was determined by immunohistochemical procedure. Histopathological investigation of brain tissues was also done.RESULTS: BM-MSCs were able to home at the injured brains and elicited significant decrease in serum TGF-β1(489.7 ± 13.0 vs 691.2 ± 8.0, P < 0.05) and MCP-1(89.6 ± 2.0 vs 112.1 ± 1.9, P < 0.05) levels associated with significant increase in serum BDNF(3663 ± 17.8 vs 2905 ± 72.9, P < 0.05) and brain DA(874 ± 15.0 vs 599 ± 9.8, P < 0.05) levels as well as brain TH(1.18 ± 0.004 vs 0.54 ± 0.009, P < 0.05) and nestin(1.29 ± 0.005 vs 0.67 ± 0.006, P < 0.05) genes expression levels. In addition to, producing insignificant increase in the number of positive cells for survivin(293.2 ± 15.9 vs 271.5 ± 15.9, P > 0.05) expression. Finally, the brain sections showed intact histological structure of the striatum as a result of treatment with BM-MSCs. CONCLUSION: The current study sheds light on the therapeutic potential of BM-MSCs against PD pathophysiology via multi-mechanistic actions. | Hanaa H Ahmed Ahmed M Salem Hazem M Atta Emad F Eskandar Abdel Razik H Farrag Mohamed A Ghazy Neveen A Salem Hadeer A Aglan | 2016 | World Journal of Stem Cells2016，8，3： | 9 |
| 3 | Efficacy and safety of botulinum toxin in treatment of anismus: A systematic review显示文摘AIM: To evaluate the efficacy and safety of botulinum toxin type A(BTX-A) in the management of patients with anismus. METHODS: An organized search of published literature was conducted using electronic databases including: Pub Med/MEDLINE, and Cochrane Central Register of Control ed Trials, also an internet-based search using 'Google Scholar' service was conducted. Both comparative and observational studies were included. We excluded irrelevant articles, editorials, case reports, reviews, and meta-analyses. The studies that followed the patients less than 6 mo were excluded. Variables collected were demographic data of the patients, technique of BTX-A injection and number of sessions, short-term and longterm clinical improvement, post-injection changes in electromyography(EMG), defecography, manometry, and balloon expulsion test, and complications recorded after BTX-A injection.RESULTS: Seven studies comprising 189 patients were included in the review. The median age of the patients was 41.2 years and female-to-male ratio was 1.3:1. The median dose of BTX-A injected per procedure was 100 IU(range, 20-100 IU). Lateral injection was done in five trails and combined lateral and posterior injections in two trials. Three studies used endorectal ultrasonographyguided technique, one study used EMG-guided technique,whereas the remaining three studies used manual palpation with the index finger. The median percentage of patients who reported initial improvement of symptoms was 77.4%(range 37.5%-86.7%), this percentage declined to a median of 46%(range 25%-100%) at 4 mo after injection of BTX-A. Rates of improvement evaluated by balloon expulsion test, EMG, and defecography ranged between(37.5%-80%),(54%-86.7%), and(25%-86.6%), respectively. Fourteen(7.4%) patients developed complications after injection of BTX-A. Complication rates across the studies ranged from 0% to 22.6%. CONCLUSION: Initial satisfactory improvement of symptoms after BTX-A injection remarkably deteriorated after 3 mo of the procedure. However, repeated injection may provide better sustained results with no additional morbidities. Further analysis of more patients is necessary to conclude the safety of BTX-A for the treatment of anismus. | Sameh Hany Emile Hossam Ayman Elfeki Hosam Ghazy Elbanna Mohamed Youssef Waleed Thabet Tito M Abd El-Hamed Basem Said Ahmed Lotfy | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，3： | 3 |
| 4 | Spontaneous complete regression of hepatic epithelioid haemangioendothelioma显示文摘 | Zaher K Otrock Aghiad Al-Kutoubi Mireille M Kattar Ghazi Zaatari Assaad Soweid | 2006 | Lancet Oncology2006，，5： | 2 |
| 5 | Computer vision-aided fabric inspection system for on-circular knitting machine 显示文摘 | Ghazi Saeidi R Latifi M Shaikhzadeh Najar S | 2005 | T R J2005，75，6： | 1 |
| 6 | Wheat response to phosphogypsum and mycorrhizal fungi in alkaline soil 显示文摘 | GHAZI N Al-KARAKI M | 2002 | Journal of Plant Nutrition2002，25，4： | 1 |
| 7 | Xanthanolides from Xanthium spinosum 显示文摘 | Omar A A Elrashidy E M Ghazy N A | 1984 | Phytochemistry1984，23，4： | 1 |
| 8 | Diagnosis of Helicbacter pylori infection by invasive and noninvasive tests显示文摘 | Pourakbari B Ghazi M Mahmoudi S | | 0，，03： | 1 |
| 9 | 显示文摘 | Shan A Y Ghazi T I M Rashid S A | 2010 | Appl Catal a Gen2010，389，12： | 1 |
| 10 | Kinetic study of jatropha biolubricant from transesterification of jatropha curcas oil with trimethylolpropane: Effects of temperature显示文摘 | Gunam Resul M F M Mohd Ghazi T I Idris A | 2012 | Industrial Crops andProduets2012，38，： | 1 |
| 11 | Pristine and Supported ZnO-based Catalysts for Phenazopyridine Degradation with Direct Solar Light显示文摘 | Hilal H S Ghazi Y M Ahed Z | | 0，，04： | 1 |
| 12 | Risk factors ofosteoporosis in healthy Moroccan men 显示文摘 | El Maghraoui A Ghazi M Gassim S | 2010 | BMC MusculoskeletDisord2010，，148： | 1 |
| 13 | Determination of rare earth elements in fluid inclusions by inductive coupled plasma-mass spectrometry显示文摘 | Ghazi A M Vanko D A Roedder E | 1993 | Geochem Cosmochim Acta1993，57，： | 1 |
| 14 | Thermal conductivity enhancement in a latent heat storage system显示文摘 | Eman-Bellah S Mettawee Ghazy M R Assassa | 2007 | Solar Energy2007，81，： | 1 |
| 15 | Immobilisation of titanium dioxide onto supporting materials in heterogeneous photocatalysis:a review显示文摘 | Shan A Y Ghazi T I M Rashid S A | 2010 | Applied Catalysis A:General2010，389，1： | 1 |
| 16 | Diabetic thermal hyperalgesia: role of TRPV1 and CB1 receptors of periaqueduetal gray 显示文摘 | Mohammadi-Farani A Sahebgbarani M Sepehrizadeh Z Jaberi E Ghazi Khansari M | 2010 | Brain Res2010，1328，： | 1 |
| 17 | The effect of dif- ferent levels of organic and inorganic chromium supplementa- tion on production performance, carcass traits and some blood parameters of broiler chicken under heat stress condition显示文摘 | Moeini M M Bahrami A Ghazi S | 2011 | Biological trace element research2011，144，13： | 1 |
| 18 | The effect of dif- ferent levels of organic and inorganic chromium supplementa- tion on immune function of broiler chicken under heat-stress conditions显示文摘 | Bahrami A Moeini M M Ghazi S H | 2012 | The Journal of Applied Poultry Research2012，21，2： | 1 |
| 19 | Trace element determination of single fluid inclusions in quartz by laser ablation ICP-MS显示文摘 | McCandless T E Lajack D J Ruiz J Ghazi A M | 1997 | Geostandard Newslett1997，21，2： | 1 |
| 20 | Prevalence of vertebral fractures in patients with rheumatoid arthritis revisiting the role of glucoeorticoids 显示文摘 | Ghazi M Koha S Briot K | 2012 | Osteoporos Int2012，23，2： | 1 |
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