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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Integratedpowertrain control of gearshifts on twin clutchtransmissions显示文摘 | Goetz M Levesley M C Crolla D A | 2004 | Transmission and DrivelineSymposium2004，，1： | 1 |
| 3 | Association with prior fluoroquinolone therapy of widespread ciprofloxacin resistance among gram-negative isolates in a veterans affairs medical center显示文摘 | MUDER R R BRENNEN C GOETZ M A | 1999 | Antimicrob Agents Chemother1999，35，： | 1 |
| 4 | Induction of male sterility in plants by metabolic engineering of the carbohydrate supply显示文摘 | Goetz M Godt D Gvivarch A | 2001 | Proc Natl Acad Sci USA2001，98，11： | 1 |
| 5 | Theory of Mind and Psychoses 显示文摘 | Doody G A Goetz M Johnstone E C | 1998 | Psychological Medicine1998，28，： | 1 |
| 6 | Acute myocardial hypoxia increases BNP gene expression显示文摘 | Goetze JP Gore A Mφller CH | 2004 | FASEB J2004，18，15： | 1 |
| 7 | The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition显示文摘 | Goetz D H Holmes M A Borregaard N | 2002 | Mol Cell2002，10，5： | 1 |
| 8 | Low-Loaded Pd/α-Al2O3 Catalysts : Influence of Metal Particle Morphology on Hydrogena- tion of Buta-1,3-diene and Hydrogenation and Isomerization of But-l-erie 显示文摘 | Goetz J Voipe M A Touroude R | 1996 | J Catal1996，164，2： | 1 |
| 9 | Quality control of embryo devel- opment 显示文摘 | Ajduk A Zernicka- Goetz M | 2013 | Mol Aspects Med2013，34，5： | 1 |
| 10 | Low-Loaded Pd-Pb/α- Al2O3 Catalysts: Effect of Alloying in the Hydrogenation of Buta-1,3-diene and Hydrogenation and Isomerization of Butenes显示文摘 | Goetz J Voipe M A Gigola C E | 2001 | J Catal2001，199，2： | 1 |
| 11 | Theory of Mind and Psychoses 显示文摘 | Doody G A Goetz M Johnstone E C | 1998 | Psychological Medicine1998，28，： | 1 |
| 12 | Integrated powertrain control of gearshifts on twin clutch transmissions 显示文摘 | Goetz M Levesley M C Crolla D A | 2004 | SAE Paper2004，，： | 1 |
| 13 | Dynamics and control of gearshift on twin-clutch transmissions显示文摘 | GOETZ M LEVESLEY M C CROLLA D A | 2005 | Journal of Automobile Engineering2005，219，8： | 1 |
| 14 | A method for a more complete in vitro Parkinson's model:slice culture bioassay for modeling maintenance and repair of the nigrostriatal circuit 显示文摘 | Keams S M Schemer B Goetz A K | 2006 | J Neurosci Methods2006，157，1： | 1 |
| 15 | Low-loaded palladium on or-alumina catalysts-characterization by chemisorption, electron-microscopy, and photoelectron-spectroscopy 显示文摘 | Goetz J Volpe M A Sica A M | 1995 | Journal of Catalysis1995，153，： | 1 |
| 16 | The impacts and implications of an intensifying fire regime on Alaskan boreal forest composition and albedo显示文摘 | BECK P S A GOETZ S J MACK M C | 2011 | Global Change Biology2011，17，9： | 1 |
| 17 | Dynamics and control of gearshifts on twin-clutch transmissions 显示文摘 | Goetz M Levesley M C Crolla D A | 2005 | Proceedings of the Institution of Mechanical Engineers Part D: Journal of Automobile Engineering2005，219，8： | 1 |
| 18 | Auxin response factor 8 is a negative regulator of fruit initiation in Arabidopsis显示文摘 | Goetz M Vivian S A Johnson S D | 2006 | The Plant Cell2006，18，8： | 1 |
| 19 | Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease显示文摘 | R Kiesslich C A Duckworth D Moussata A Gloeckner L G Lim M Goetz D M Pritchard P R Galle M F Neurath A J M Watson | 2012 | Gut2012，，8： | 1 |
| 20 | N-terminal glutamate to pyroglutamate conversion in vivo for human Ig G2 antibodies显示文摘 | LIU Y D GOETZE A M BASS R B | 2011 | J Biol Chem2011，286，11： | 1 |
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