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| 1 | 胃癌预防亚太地区共识指南显示文摘背景与目的:胃癌是亚太地区的主要健康负担之一,但对其预防策略尚缺乏共识。本共识会议旨在评价预防胃癌的策略。方法:多学科专家组应用德尔菲(Delphi)法制订共识条文,提呈相关数据,对证据等级、推荐强度以及共识水平予以分级。结果:幽门螺杆菌(H.pylori)感染是非贲门胃腺癌必要但非充分的致病因子。盐的高摄入与胃癌强烈相关。新鲜果蔬对胃癌具有预防作用,但维生素和其他饮食补充并不能预防胃癌。H.pylori感染中的宿主-细菌相互作用导致不同类型的胃炎和胃酸分泌,从而决定疾病结局。胃癌阳性家族史是一个重要的危险因素。低血清胃蛋白酶原反映胃萎缩程度,可作为检出胃癌高危人群的标志物。H.pylori筛查和治疗被推荐作为减少高危人群胃癌危险性的一种策略,该策略在萎缩性胃炎发生前实施最为有效,但并不排除对胃癌高危人群的内镜监测。对胃癌低危人群不推荐行H.pylori筛查。H.pylori感染的一线治疗应遵循国家治疗指南。结论:高危人群中H.pylori筛查和根除策略可能会减少胃癌的发生率,本共识根据现有证据予以推荐。 | Kwong Ming Fock Nick Talley Paul Moayyedi Richard Hunt Takeshi Azuma Kentaro Sugano Shu Dong Xiao Shiu Kum Lam Khean Lee Goh Tsutomu Chiba Naomi Uemura Jae G Kim Nayoung Kim Tiing Leong Ang Varocha Mahachai Hazel Mitchell Abdul Aziz Rani Jyh Ming Liou Ratha-korn Vilaichone Jose Sollanor 钱本余 | 2008 | 胃肠病学2008，13，4： | 37 |
| 2 | Hepatitis B-specific T helper cell responses in uninfected infants born to HBsAg^(+)/HBeAg^(-) mothers显示文摘Vertically transmitted hepatitis B virus(HBV)usually causes chronic infection.While combined active–passive immunoprophylaxis in neonates of hepatitis B surface antigen-positive(HBsAg1)mothers at birth prevents vertical transmission,it is not yet clear whether neonates encounter the virus or its products in the absence of hepatitis B e antigen(HBeAg).This study was undertaken to investigate HBV antigen-specific T-cell responses in vaccinated neonates of HBsAg1/HBeAg2 mothers.Blood was collected from 46 HBsAg1 mothers and their neonates(subjects)as well as 24 age-matched controls.All neonates of HBsAg1 mothers received appropriate immunoprophylaxis,and HBsAg and hepatitis B surface antibody(anti-HBs)antibody titers were determined after completion of the vaccination course.Peripheral blood mononuclear cells(PBMCs)from infants at birth,1 and 6 months of age were stimulated with recombinant HBsAg,hepatitis B core antigen(HBcAg)and mitogen,and interferon(IFN)-c concentrations were determined by ELISA.HBsAg-induced production of IL-2,IL-5,IL-6 and IL-10 was assessed using a cytometric bead array kit on cells from 6-month-old neonates post-vaccination.All neonates were HBsAg2 and responded to vaccination.Increased IFN-c production following HBcAg stimulation was seen in 30.4%of neonates born to HBsAg1/HBeAg2 mothers.Subjects demonstrated significantly higher IL-2 production post-HBsAg stimulation,whereas IL-5,IL-6 and IL-10 cytokine responses were not significantly different.Almost one-third of uninfected neonates developed viral antigen-induced IFN-c production,suggesting that they had been exposed to virions or viral derivatives.This encounter,however,did not impair their T-cell responses to vaccination. | Lemonica Koumbi Antonio Bertoletti Vassiliki Anastasiadou Maria Machaira Winnie Goh Nikolaos G Papadopoulos Dimitris A Kafetzis Vassiliki Papaevangelou | 2010 | Cellular & Molecular Immunology2010，7，6： | 4 |
| 3 | Donor-specific cell-free DNA as a biomarker in liver transplantation:A review显示文摘Due to advances in modern medicine,liver transplantation has revolutionised the prognosis of many previously incurable liver diseases.This progress has largely been due to advances in immunosuppressant therapy.However,despite the judicious use of immunosuppression,many liver transplant recipients still experience complications such as rejection,which necessitates diagnosis via invasive liver biopsy.There is a clear need for novel,minimally-invasive tests to optimise immunosuppression and improve patient outcomes.An emerging biomarker in this‘‘precision medicine’‘liver transplantation field is that of donorspecific cell free DNA.In this review,we detail the background and methods of detecting this biomarker,examine its utility in liver transplantation and discuss future research directions that may be most impactful. | Tess McClure Su Kah Goh Daniel Cox Vijayaragavan Muralidharan Alexander Dobrovic Adam G Testro | 2020 | World Journal of Transplantation2020，10，11： | 2 |
| 4 | Hydrothermal epitaxy of KTaO3 thin films显示文摘 | GOH G K L LEVI C G LANGE F F | 2002 | J Mater Res2002，17，11： | 1 |
| 5 | An analysis of fire sizes, fire growth rates and times between events using data from fire investigations 显示文摘 | Holbom P G Nolanpf Goh J | 2004 | Fire Safety Journal2004，39，6： | 1 |
| 6 | Whole-exome se- quencing characterizes the landscape of somatic mutations and copy number alterations in adrenocortical carcinoma显示文摘 | JUHLIN C C GOH G HEALY J M | 2015 | J Clin Endocrinol Metab2015，100，3： | 1 |
| 7 | Gold mineralization and Zonation in Kelantan显示文摘 | Goh S H Teh G H Wan F W H | 2006 | Geological Society of Malaysia Bulletin2006，52，： | 1 |
| 8 | Association be- tween BRCAI and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer 显示文摘 | Bohon KL Chenevix-Trench G Goh C | 2012 | JAMA2012，307，4： | 1 |
| 9 | Pineal yolk sac tumour with a solid pattern:a case report in a Chinese adult man with Down′s syndrome显示文摘 | Tan H W Ty A Goh S G N | 2004 | J Clin Pathol2004，57，： | 1 |
| 10 | Vector Network Equilibrium Problems and Nonlinear Scalarization Methods 显示文摘 | CHEN G Y GOH C J YANG X Q | 1999 | Mathematical Methods of Operations Research1999，49，： | 1 |
| 11 | Measurement of in vitro dissolution of aerosol particles for comparison to in vivo dissolution in the lower respiratory tract after inhalation显示文摘 | Kanapilly G M Raabe O G Goh C H T | 1973 | Health Physics1973，24，5： | 1 |
| 12 | Electroactive polymer-SiO2 nanocomposites for metal uptake显示文摘 | Tan K K Goh P L | 1999 | Polymer1999，40，： | 1 |
| 13 | CBSA:Content-based annotation for multimodal image retrieval using bayes point machines显示文摘 | Chang E Goh K Sychay G | 2002 | IEEE Transactions on Circuits and Systems for Video Technnlogy2002，13，1： | 1 |
| 14 | Patients' complaints in a hospital emergeney department in Singapore 显示文摘 | WONG L L 00I S B S GOH L G | 2007 | Singapore Med2007，48，11： | 1 |
| 15 | Istologic e valuation of intracordal autologous cartilage injection in the paralyzed canine vocal fold at two and three years显示文摘 | LEE B J WANG S G GOH E K | 2006 | Otolaryngol Head Neck Surg2006，134，： | 1 |
| 16 | Wireless sensor networks in agriculture: cattle monitoring for farming industries显示文摘 | Kwong K H Wu T T Goh H G | 2009 | PIERS Online2009，5，1： | 1 |
| 17 | The chromaticity of some families of complete tripartite graphs显示文摘 | Chia G L Goh B H Koh K M | 1988 | SCIENTIA Series A: Math Sci1988，2，： | 1 |
| 18 | Application of Aphidius colemaniViereck for Control of the Aphid in Greenhouse显示文摘 | Goh H G Kim J H Han M W | 2001 | Journal of A-sia-Pacific Entomology2001，4，2： | 1 |
| 19 | Characterization of oils and fats by^1H NMR and GC/MS fingerprinting: classifica- tion, prediction and detection of adulteration 显示文摘 | Fang G H Goh J Y Tay M | 2013 | Food Chemistry2013，138，： | 1 |
| 20 | Hybrid Bayesian back-propagation neural network approach to multivariate modeling显示文摘 | Chua C G Goh A T C | 2003 | International Journal for Numerical and Analytical Methods in Geomechanics2003，27，8： | 1 |
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