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| 1 | 在嗜曙红的食道炎的管理的内视镜检查法的贡献显示文摘 Eosinophilic esophagitis (EoE) is a clinicopathological entity characterized by a set of symptoms similar to gastroesophageal reflux disease and eosinophilic infi ltration of the esophageal epithelium. EoE is an emerging worldwide disease as documented in many countries. Recent reports indicate that EoE is increasingly diagnosed in both pediatric and adult patients although the epidemiology of this new disease entity remains unclear. It is unclear whether EoE is a new disease or a new classification of an old esophageal disorder. Esophagogastroduodenoscopy (EGD) and biopsies with histological examination of esophageal mucosa are required to establish the diagnosis of EoE, verify response to therapy, assess disease remission, document and dilate strictures and evaluate symptom recurrence of EoE. Repeated endoscopies with biopsies are necessary for monitoring of disease progression and treatment effi cacy. EGD has a fundamental role in the diagnosis and management of EoE, forming an essential part of the investigation and follow-up of this condition. EoE is now considered a systemic disorder and not only a local condition with an important immunological back-ground. One of the aims of research in EoE is to study non-invasive markers, such as immune indicators found in plasma, that correlate with local presence of EoE in esophageal tissues. Studies over the next few years will provide new information about diagnosis, pathogenesis, endoscopic/histologic criteria, non-invasive markers, novel and more eff icacious treatments, as well as establishing natural history. Randomized clinical trials are urgently called for to inform non-invasive diagnostic tests, hallmarks of natural history and more eff icacious treatment approaches for patients with EoE. The collaboration between pediatric and adult clinical and experimental studies will be paramount in the understanding and management of this disease. | Cristina Targa Ferreira Helena AS Goldani | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，8： | 3 |
| 2 | Serum proinflammatory cytokines and nutritional status in pediatric chronic liver disease显示文摘AIM: To evaluate the nutritional status and its association with proinflammatory cytokines in children with chronic liver disease.METHODS: We performed a cross-sectional study with 43 children and adolescents, aged 0 to 17 years, diagnosed with chronic liver disease. All patients regularly attended the Pediatric Hepatology Unit and were under nutritional follow up. The exclusion criteria were fever from any etiology at the time of enrollment, inborn errors of the metabolism and any chronic illness. The severity of liver disease was assessed by Child-Pugh, Model for End-stage Liver Disease(MELD) and Pediatric End Stage Liver Disease(PELD) scores. Anthropometric parameters were height/age, body mass index/age and triceps skinfold/age according to World Health Organization standards. The cutoff points for nutritional status were risk of malnutrition(Z-score <-1.00) and malnutrition(Z-score <-2.00). Interleukin-1β(IL-1β), IL-6 and tumor necrosis factor-α levels were assessed by commercial ELISA kits. For multivariate analysis, linear regression was applied to assess the association between cytokine levels, disease severity and nutritional status. RESULTS: The median(25th-75 th centile) age of the study population was 60(17-116)-mo-old, and 53.5% were female. Biliary atresia was the main cause of chronic liver disease(72%). With respect to Child-Pugh score, cirrhotic patients were distributed as follows: 57.1% Child-Pugh A, a mild presentation of the disease, 34.3% Child-Pugh B, a moderate stage of cirrhosis and 8.6% Child-Pugh C, were considered severe cases. PELD and MELD scores were only above the cutoff point in 5 cases. IL-6 values were increased in patients at nutritional risk(34.9%) compared with those who were well-nourished [7.12(0.58-34.23) pg/m L vs 1.63(0.53-3.43) pg/m L; P = 0.02], correlating inversely with triceps skinfold-for-age z-score(rs =-0.61; P < 0.001). IL-6 levels were associated with liver disease severity assessed by Child-Pugh score(P = 0.001). This association remained significant after adjusting for nutritional status in a linear regression model. CONCLUSION: High IL-6 levels were found in children with chronic liver disease at nutritional risk. Inflammatory activity may be related to nutritional status deterioration in these patients. | Daniele Santetti Maria Inês de Albuquerque Wilasco Cristina Toscani Leal Dornelles Isabel Cristina Ribas Werlang Fernanda Urruth Fontella Carlos Oscar Kieling Jorge Luiz dos Santos Sandra Maria Goncalves Vieira Helena Ayako Sueno Goldani | 2015 | World Journal of Gastroenterology2015，21，29： | 2 |
| 3 | Pharmacokinetics of in?travenous polymyxin B in critically ill patients显示文摘 | Zavascki AP Goldani L2 Cao G et a1 | 2008 | Clin Infect Dis2008，47，10： | 1 |
| 4 | Developmental origins of health and disease (DOHaD) 显示文摘 | Silveira PP Portella AK Goldani MZ | 2007 | J Pediatr ( Rio J)2007，83，6： | 1 |
| 5 | Comparison of Shear Bond Strength of RMGI and Composite Resin for Orthodontic Bracket Bonding显示文摘 | Yassaei S Davari A Goldani Moghadam M | 2014 | J Dent(Tehran)2014，11，3： | 1 |
| 6 | Polymyxin B for the treatment of multidrug-resistant pathogens~a critical review显示文摘 | Zavascki AP Goldani LZ Li J | 2008 | J Antimierob Chemother2008，60，6： | 1 |
| 7 | Polymyxin B for the treat?ment of multidrug-resistant pathogens: a critical review显示文摘 | Zavascki AP Goldani L2 Li J | 2007 | J An?timicrob Chemother2007，60，6： | 1 |
| 8 | Polymyxin B for the treatment of multidrug-resistant pathogens:a critical review显示文摘 | ZAVASCKI AP GOLDANI LZ LI J | 2007 | Antimicrob Chemother2007，60，6： | 1 |
| 9 | Update on the contribution of galactomannan for the diagnosis of invasive aspergillosis显示文摘 | Aquino VR Goldani LZ Pasqualotto AC | 2007 | Mycopathologia2007，163，4： | 1 |
| 10 | Cesarean section and increased body mass index in school children:two cohort studies from distinct socioeconomic background areas in Brazil显示文摘 | Goldani MZ Barbieri MA da Silva AAM | 2013 | Nutr J2013，，12： | 1 |
| 11 | The role of food restriction on CC14-induced cirrhosis model in rats 显示文摘 | Goldani HA Matte US Ramos AR | 2007 | Exp Toxicol Pathol2007，58，5： | 1 |
| 12 | Biomarkers in autism 显示文摘 | Andre A Goldani S Downs SR | 2014 | Frontiers in psychiatry2014，5，110： | 1 |
| 13 | Experimental Rhodotorulosis infection in rats显示文摘 | Wirth F Goldani LZ | 2012 | Apmis2012，，： | 1 |
| 14 | Risk factors for imipenem resistant Pseudomonas aeruginosa 显示文摘 | Zavascki A P Cruz R P Goldani L Z | | Hospital Infect0，59，12： | 1 |
| 15 | Update on the contribu- tion of galactomannan for the diagnosis of invasive aspergillosis 显示文摘 | Aquino VR Goldani LZ Pasqualotto AC | 2007 | Mycopathologia2007，163，4： | 1 |
| 16 | Do early life fac- tors influence body mass index in adolescents? 显示文摘 | Goldani MZ Haeffner LSB Agranonik M | 2007 | Braz J Med Bi- ol Res2007，40，： | 1 |
| 17 | Low birth weight in Silo Luis, northeastern Brazil, trends and associated factors 显示文摘 | Helma Jane Ferreira Veloso Ant6nio Augusto Moura da Silva Helolsa Bettiol Marcelo Zubarin Goldani Fernando Lamy Filho Vanda Maria Ferreira Sim6es Rosgmgela Fernandes Lucena Batista Marco Ant6nio Barbieri | 2014 | BMC Pre Child2014，14，1： | 1 |
| 18 | Pharmacokinetics of intravenous polymyxin B in critically ill patients显示文摘 | Zavascki AP Goldani LZ Cao G | 2008 | Clin Infect Dis2008，47，10： | 1 |
| 19 | Polymycin B for the treatment of multidrug-resistant pathogen: a critical review显示文摘 | Zavascki A P Goldani L Z Li J | 2007 | Antimicrob Chemother2007，60，6： | 1 |
| 20 | Update on the contribution of galactomannan for the diagnosis of invasive aspergillosis 显示文摘 | Aquino VR Goldani LZ Pasqualotto AC | 2007 | Mycopathologia2007，163，4： | 1 |
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