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| 1 | Effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease显示文摘AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and 1H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs. | E Louise Thomas Audrey E Brynes Gavin Hamilton Nayna Patel Adam Spong Robert D Goldin Gary Frost Jimmy D Bell Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，36： | 13 |
| 2 | Hepatic steatosis and fibrosis: Non-invasive assessment显示文摘Chronic liver disease is a major cause of morbidity and mortality worldwide and usually develops over many years, as a result of chronic inflammation and scarring, resulting in end-stage liver disease and its complications. The progression of disease is characterised by ongoing inflammation and consequent fibrosis, although hepatic steatosis is increasingly being recognised as an important pathological feature of disease, rather than being simply an innocent bystander. However, the current gold standard method of quantifying and staging liver disease, histological analysis by liver biopsy, has several limitations and can have associated morbidity and even mortality. Therefore, there is a clear need for safe and noninvasive assessment modalities to determine hepatic steatosis, inflammation and fibrosis. This review covers key mechanisms and the importance of fibrosis and steatosis in the progression of liver disease. We address non-invasive imaging and blood biomarker assessments that can be used as an alternative to information gained on liver biopsy. | Rustam N Karanjia Mary ME Crossey I Jane Cox Haddy KS Fye Ramou Njie Robert D Goldin Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，45： | 6 |
| 3 | The epidemiology, pathogenesis and histopathology of fatty liver disease显示文摘 | Adam P Levene Robert D Goldin | 2012 | Histopathology2012，，2： | 2 |
| 4 | Blood flow volume changes in the maturing arteriovenous access for hemodi- alysis 显示文摘 | Shemesh D Goldin I Berelowitz D | 2007 | Ultrasound Med Bioi2007，33，： | 1 |
| 5 | Intra-craniaI volume change in childhood显示文摘 | SGOUROS S GOLDIN J H HOCKLEY A D | | 0，，02： | 1 |
| 6 | Stage does not predict survival after resection of hilar cholangiocarcinomas promoting an aggressive operative approach显示文摘 | Zervos EE Osborne D Goldin SB | 2005 | Am J Surg2005，190，： | 1 |
| 7 | Histological outcome during long term lamivudine therapy 显示文摘 | DIENSTAG J L GOLDIN R D HEATHCOTE E J | 2003 | Gastroenterology2003，124，1： | 1 |
| 8 | Surgical management of radiation-induced heart disease 显示文摘 | VEERAGANDBAM R S GOLDIN M D | 1998 | Ann Thorac Surg1998，65，4： | 1 |
| 9 | Natural radiation in the urban environment显示文摘 | YEATES D B GOLDIN A S MOELLER D W | 1972 | Nuclear Safety1972，13，4： | 1 |
| 10 | Inflammatory myofibroblastic tumor of the midesophagus 显示文摘 | Goldin SB Osborne D Paidas C | 2007 | Fetal Pediatr Pathol2007，26，5： | 1 |
| 11 | Equal Access VS Selective Access; A Cfitigque of Public Goods Theory 显示文摘 | Goldin Kenneth D | 1979 | Public Choice1979，，： | 1 |
| 12 | Management of chronic hepatitis C:clinical audit of biopsy based management algorithm 显示文摘 | FOSTER G R GOLDIN R D MAIN J | 1997 | BMJ1997，315，7106： | 1 |
| 13 | Mouse models in non-alcoholic fatty liver disease and steatohepatitis research显示文摘 | ANSTEE Q M GOLDIN R D | 2006 | Exp Pathol2006，87，： | 1 |
| 14 | Chronic hepatitis C virus infection causes a significant reduction in quality of life in the absence of cirrhosis显示文摘 | Foster G R Goldin R D Thomas H C | 1998 | Hepatology1998，27，1： | 1 |
| 15 | Imaging lung disease in systemic sclerosis 显示文摘 | Strollo D Goldin J | 2010 | Curr Rheumatol Rep2010，12，2： | 1 |
| 16 | Progression of coronary artery calcification in patients taking alendronate for osteoporosis显示文摘 | Hill J A Goldin J G Gjertson D | 2002 | Acad Radiol2002，9，10： | 1 |
| 17 | Histological outcome during long-term lamivudine therapy显示文摘 | DIENSTAG J L GOLDIN R D HEATHCOTE E J | 2003 | Gastroenterology2003，124，1： | 1 |
| 18 | Wheat grass juice in the treatment of active distal ulcerative colitis 显示文摘 | Arye E Goldin E Wengrower D | 2002 | A Randomized Double-blind Placebo-controlled Trial2002，37，4： | 1 |
| 19 | Extended lamivudine treatment in patients with HBeAg-negative chronic hepatitis B显示文摘 | RIZZETTO M TASSOPOULOS N C GOLDIN R D | 2005 | J Hepatol2005，42，2： | 1 |
| 20 | Imaging lung disease in systemic sclerosis 显示文摘 | Strollo D Goldin J | 2010 | Curt Rheumatol Rep2010，12，2： | 1 |
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