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| 1 | 短期针刺足三里对脂多糖诱导的大鼠急性肺损伤的预防作用(英文)显示文摘目的:研究短期手法针刺足三里治疗对脂多糖诱导的实验性大鼠急性肺损伤的预防作用。方法:根据是否进行脂多糖刺激及采用的针刺方法的不同,将32只 Wistar 大鼠随机分为4组,即正常对照组、模型组、假针刺组和针刺组,每组8只。假针刺组和针刺组大鼠行手法针刺治疗,连续治疗4 d,每次 5 min。第4天针刺后采用脂多糖刺激诱导大鼠急性肺损伤。第5天,收集外周血、支气管肺泡灌洗液和骨髓等进行白细胞计数。结果:血细胞计数和支气管肺泡灌洗液细胞计数提示,针刺可减轻急性肺损伤大鼠的炎性反应,假针刺也有轻微的效果。正常对照组和模型组大鼠无明显的炎性反应。与正常对照组比较,模型组肺泡灌洗液中细胞计数增加;与假针刺组比较,针刺组肺泡灌选液中细胞计数减少,但差异没有统计学意义。结论:预防性手法针刺足三里可减轻脂多糖诱导的大鼠急性肺损伤,但其相关免疫机制仍待进一步的研究。 | Arthur de Sá FERREIRA Januário Gomes Mourāo e LIMA Tatiana Pereira Teixeira FERREIRA Camila Madeira Tavares LOPES Rubens MEYER | 2009 | 中西医结合学报2009，7，10： | 21 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Declining NAD + Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging显示文摘 | Ana P. Gomes Nathan L. Price Alvin J.Y. Ling Javid J. Moslehi Magdalene K. Montgomery Luis Rajman James P. White Jo?o S. Teodoro Christiane D. Wrann Basil P. Hubbard Evi M. Mercken Carlos M. Palmeira Rafael de Cabo Anabela P. Rolo Nigel Turner Eric L. Bel | 2013 | Cell2013，，7： | 2 |
| 4 | 体外评估自酸蚀粘结剂的釉质封闭能力显示文摘目的:尽管有报道自酸蚀釉质粘合剂存在粘结不足的缺陷.自酸蚀粘结剂的应用在不断扩大.有些临床医师选择单独酸蚀釉质以弥补其缺陷。本研究目的是评估3种自酸蚀粘结剂在热疲劳后,酸蚀对釉质封闭的影响。材料与方法:取30颗牛切牙,在每颗牙上预备两个箱状洞型,分别用Adper Prompt L-Pop(3MESPE)、Clearfil SE Bond(Kuraray America)和iBond(Heraeus Kulzer)这三种自酸蚀粘结剂中的一种处理窝洞。其中部分先用磷酸酸蚀釉质,另一部分直接涂布自酸蚀粘结剂,然后用FiltekZ250(3MESPE)充填洞型。然后取一半的充填体置于1500个热循环中使之疲劳,再用50%硝酸氨银来检验材料的边缘封闭能力。银离子渗透按O~4分级.材料界面通过黑点探测器在发散区域扫描电镜(FESEM)下分析。用非参数统计计算出一个95%的可信区间。结果:Clearfil SE Bond的釉质微渗漏显著低于另两个自酸蚀粘结剂。对置于热循环后的标本,酸蚀能显著降低所有自酸蚀粘结剂的银离子渗透。对没有经过热循环的标本,酸蚀只能减少iBond的银离子渗透。在FESEM下.银离子沉淀可被发现位于Adper Prompt L-Pop和iBond的粘结层中.而Clearfil SE Bond处理后的10个标本中只有2个表现出银离子沿釉质粘结界面渗透。结论:标本在热循环疲劳状态.磷酸酸蚀能提高3种自酸蚀粘结剂的釉质边缘封闭能力。 | Jorge Perdigǎo Paulo Monteiro George Gomes 李珍(译) | 2009 | 中国口腔医学继续教育杂志2009，，4： | 2 |
| 5 | 2004年加拿大预防血透病人医院血流感染的成本-效益分析显示文摘目的:血液透析相关的血流感染是一个严重的公共健康问题,因为加拿大的血液透析病人从1996年到2005翻了一番。本研究目的在于确定加拿大医院血流感染的成本,估算在综合性医院中建立感染控制项目的成本,并进行成本-效益分析。材料与方法:用加拿大医院感染监测项目的数据来估算医院血流感染的发生率。用加拿大健康信息所数据来估算2004年加拿大平均一次血流感染住院的额外成本。建立和维护一个感染控制项目的成本用美国疾病预防与控制中心1985年的成本换算为2004年的加拿大成本来估算。假设感染控制项目能降低医院血流感染病例的20%~30%。结果:2004年的加拿大15278名血液透析病人中估计共有2524人发生血流感染。全年用于治疗血流感染的成本估计为4901万加元。医院血流感染预防和人力资源的总投资成本为815万加元。建立医院感染控制项目后能带来1452万加元的医疗成本节约。效益成本比在1.0:1到1.8:1之间。结论:本研究提供的证据表明,如果医院感染控制项目能降低20%~30%的感染,该项目的经济效益将远超过增加的成本。医院感染控制项目将带来双重效益:节约货币成本的同时改善医疗质量。 | Zhiyong Hong MD DrPH Jun Wu PhD Crystal O'Leary BHSc Clem Tisdell James Gomes Shi-Wu Wen Howard Njoo 李洪超 | 2010 | 中国药物经济学2010，，1： | 2 |
| 6 | Anti- Helicobacter pylori activity of Terminalia macroptera root显示文摘 | Olga Silva Sílvia Viegas Cristina de Mello-Sampayo Maria Jo?o P. Costa Rita Serrano José Cabrita Elsa T. Gomes | 2012 | Fitoterapia2012，，5： | 2 |
| 7 | Growth of rainbow trout fed a diet supplemented with earthworms, after chemical treatment显示文摘 | Pereira J O Gomes E F | 1995 | Aquaculture International1995，3，： | 1 |
| 8 | Reconciling Distance Functions and Level Sets显示文摘 | Gomes J Faugeras O | 2000 | Journal of Visional Communication and Image Representation2000，，： | 1 |
| 9 | Medley GF (2004) The reinfection threshold promotes variability in tuberculosis epidemiology and vaccine efficacy显示文摘 | Gomes M G Franco A O Gomes M C | 2004 | Proceedings of the Royal Society B Biological Sciences2004，271，： | 1 |
| 10 | Lending relationships in the interbank market显示文摘 | Jo?o F. Cocco Francisco J. Gomes Nuno C. Martins | 2008 | Journal of Financial Intermediation2008，，1： | 1 |
| 11 | Role of plant lipid transfer proteins in plant cell physiology-A concise review显示文摘 | Oliveira Carvalho A O Gomes V M | 2007 | Peptides2007，28，： | 1 |
| 12 | Numerical modeling of an industrial aluminum melting furnace显示文摘 | Nieckele A O Naccache M F Gomes M S P | 2004 | Journal of Energy Resources Technology2004，126，1： | 1 |
| 13 | Reproductive quality of male Penaeus mondon 显示文摘 | Gomes L A O Honculada - Primavera J | 1993 | Aquaculture1993，112，： | 1 |
| 14 | The bootstrap methodology in statistics of extremes-choice of the optimal sample fraction显示文摘 | OLIVEIRA O | 2001 | Extremes2001，4，4： | 1 |
| 15 | Investigation of springback in high strength anisotropic steels 显示文摘 | Gomes C Onipede O Lovell M | 2005 | Journal of Material Processing Technology2005，159，1： | 1 |
| 16 | Third-order nonlinear optical properties of bismuth-borate glasses measured by conventional and thermally managed eclipse Z scan 显示文摘 | Gomes A S L Falc o Filho E L de Araujo Cid B etal | 2007 | J Appl Phys2007，101，03： | 1 |
| 17 | Mode-locked ytterbium fiber laser tunable in the 980-1070 nm spectral range 显示文摘 | Okhotnikov O G Gomes L Xiang N | 2003 | OptLett2003，28，17： | 1 |
| 18 | Application of high performance liquid chromatography coupled with ultraviolet spectroscopy and electrospray mass spectrometry to the characterization of ellagitannins from Terminalia macropera roots 显示文摘 | Silva O Gomes ET Wolfender JL | 2000 | Pharm Res2000，17，11： | 1 |
| 19 | Bacterial community composition in Brazilian anthrosols and adjacentsoils characterized using culturing and molecular identify- cation显示文摘 | O'Neill B Grossman J Tsai MT Gomes JE Lehmann J Peterson J Neves E Theis JE | 2009 | Microbial Ecology2009，58，： | 1 |
| 20 | Determination of sugars, and some other compounds in infant formulae, follow-up milks and human milk by HPLC-UV/RI显示文摘 | Ferreira I M P L V O Gomes A M P Ferreira M A | 1998 | Carbohydrate Polymers1998，37，： | 1 |
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