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	题名	作者	年代	出处	被引量
1	N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized,placebo-controlled pilot study显示文摘AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects.	Luis G Guijarro Jose Mate Javier P Gisbert Jose Luis Perez-Calle Ignacio Marín-Jimenez Encarna Arriaza Tomás Olleros Mario Delgado Maria S Castillejo David Prieto-Merino Venancio Gonzalez Lara Amado Salvador Pea	2008	World Journal of Gastroenterology2008，14，18：	2
2	Diffusion-weighted MR imaging of the brain显示文摘	Schaefer PW Grant PE Gonzalez RG	2000	Radiology2000，217，：	1
3	Diffusion-weighted MR imaging of the brain显示文摘	Schaefer PW Grant PE Gonzalez RG	2000	Radiology2000，217，2：	1
4	Diffusion-weighted MRimaging of the brain显示文摘	Schaefer PW Grant PE Gonzalez RG	2000	Radiology2000，217，3：	1
5	Diagnostic accura- cy of presepsin ( soluble CD14 subtype) for prediction of bacteremia in patients with systemic inflammatory response syndrome in the e- mergency department显示文摘	Romualdo LG Torrella PE Gonzalez MV	2014	Clin Biochem2014，47，78：	1
6	Diffusion-weighted MR imaging of the brain显示文摘	Schaefer PW Grant PE Gonzalez RG	2000	Radiology2000，217，2：	1
7	Diffusion-weighted MR imaging of the brain 显示文摘	Schaefer PW Grant PE Gonzalez RG	2000	Radiology2000，217，2：	1
8	Invitro antifungal activity of isavuconazole against 345 mucoralesisn-lates collected at study centers in eight countries 显示文摘	VERWEIJ PE GONZALEZ GM WIEDRHOLD NP	2009	J Chemoth-er2009，21，3：	1
9	Quantitative and qualitative effects of chemical peeling on photo-aged skin:an experimental study显示文摘	Butler PE Gonzalez S Randolph MA	2001	Plast Reconstr Surg2001，107，1：	1
10	Quantitative anti qualitative effects of chemical peeling on photo-aged skin: an experimental study 显示文摘	Butler PE Gonzalez S Randolph MA	2001	Plast Reconstr Surg2001，107，：	1
11	Diffusion-weighted MR imaging of the brain显示文摘	Schaefer PW Grant PE Gonzalez RG	2000	Radiology2000，217，2：	1
12	Diffusion-weighted MR imaging of the brain显示文摘	Schaefer PW Grant PE Gonzalez RG	2000	Radiology2000，217，2：	1
13	Clinical implications]显示文摘	Yebra PE Gonzalez JM Cervino A	2004	Arch Soc Esp Oftalmol2004，79，8：	1
14	Diffusion-weighted MR imaging of the brain 显示文摘	Schaefer PW Grant PE Gonzalez RG	2000	Radiology2000，217，2：	1
15	Diffusion-weighted MR imaging of the brain显示文摘	Schaefer PW Grant PE Gonzalez RG	2000	Radiology2000，217，2：	1
16	Diffusion-weighted MR imaging of the brain显示文摘	Grant PE Gonzalez RG	2000	Radiology2000，217，2：	1
17	Diffusion weighted MR imaging of the brain显示文摘	Schaefer PW Grant PE Gonzalez RG	2000	Radiology2000，217，2：	1
18	Diffusion-weighted MR imaging of the brain显示文摘	Schaefer PW Grant PE Gonzalez RG	2000	Radiology2000，217，2：	1
19	Diffusion-weighted MR imaging of the brain显示文摘	Schaefer PW Grant PE Gonzalez RG		0，，：	1
20	Diffusion-weighted MR imaging of the brain显示文摘	Schaefer PW Grant PE Gonzalez RG	2000	Radiology2000，217，2：	1

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