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| 1 | 膝关节前交叉韧带损伤及重建后肌肉力量变化的研究显示文摘对ACL陈旧性损伤、急性损伤、手术重建以及未损伤对象四个样本组 ,在等长条件下膝关节肌肉屈伸、旋内 ,旋外、内收和外展的力量情况进行了对比测试。共记录了 5 4个研究对象的 80组测试结果。结果表明各样本组肌肉力量比值在不同方向上存在显著性差异。该结果可能有助于解释ACL损伤及重建后神经肌肉系统的补偿机制 ,并提示通过选择性地训练某些肌肉可达到有效的康复效果。 | 王广志 张立群 Gordon W Nuber Mark K Bowen Jesse Butler | 2000 | 中国运动医学杂志2000，19，4： | 13 |
| 2 | 加兰他敏治疗轻至中度阿尔茨海默病人的有效性及安全性:多中心随机对照试验显示文摘 | Gordon K Wilcock Sean Lilienfeld Els Gaens 殷剑 | 2001 | 英国医学杂志中文版2001，4，4： | 5 |
| 3 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | The Lancet2001，，9286： | 4 |
| 4 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | The Lancet . 2001 (9286)2001，，9286： | 4 |
| 5 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | 2001 (9286)2001，，9286： | 4 |
| 6 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 7 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 8 | Label-retaining liver cancer cells are relatively resistant to sorafenib显示文摘 | Hong-Wu Xin Chenwi M Ambe Danielle M Hari Gordon W Wiegand Tyler C Miller Jin-Qiu Chen Andrew J Anderson Satyajit Ray John E Mullinax Tomotake Koizumi Russell C Langan Douglas Burka Michelle A Herrmann Paul K Goldsmith Alexander Stojadinovic Udo Rudloff S | 2013 | Gut2013，，12： | 2 |
| 9 | Fast Surface Tracking in 3D Binary Images显示文摘 | Gordon D Udupa J K | 1989 | Computer Vision Graphics and Image Processing1989，45，2： | 2 |
| 10 | The oscillation frequency of a quartz crystals immersed in organic liquids 显示文摘 | Kanazawa K K Gordon J G | 1985 | Anal Chim Acta1985，175，9： | 2 |
| 11 | WONCA研究论文摘要汇编——初级保健服务中慢性疼痛的自我管理障碍:一项基于专题小组讨论的定性研究显示文摘背景自我管理是被推崇的慢性疼痛干预方法。有效地自我管理可以减少疼痛对患者日常生活的影响。临床指南指出初级保健服务有助于慢性疼痛患者的自我管理。目的分析初级保健专业人员、慢性疼痛患者及其照顾者对慢性疼痛自我管理的意见,在此基础上探究不利于应用和开展慢性疼痛自我管理的因素。设计与场所此项定性研究在苏格兰开展,研究对象为数个专题小组。方法共有18个小组参与专题讨论,包括54名慢性疼痛患者、9名慢性疼痛患者的照顾者以及38名初级保健专业人员。结果通过分析各小组的观点,得出4类不利于慢性疼痛自我管理的因素:(1)不和谐的医患沟通:部分患者认为自我管理慢性疼痛已经为时过晚或者不重要。医生和患者很难沟通,难以构建良好的医患关系;(2)患者体验:由于没有设身处地地考虑慢性疼痛对患者情绪的影响,使得患者常觉得初级保健专业人员对他们的治疗不积极;(3)有限的治疗方案:一些研究对象感觉治疗有过度医疗化的倾向;(4)机构的组织管理缺点:医生用于诊疗患者的时间短,患者候诊时间长,以及英国国家医疗服务体系实行的分级诊疗带来的看病困难问题。结论此项研究分析了应用与开展慢性疼痛自我管理所面临的挑战。如果自我管理是治疗慢性疼痛的一种重要方法,初级保健专业人员需要找到解决不利因素的方法,以使其顺利应用与开展。 | GORDON K RICE H ALLCOCK N 本刊编辑部 | 2017 | 中国全科医学2017，20，12： | 2 |
| 12 | XIAP regulates akt activity and caspase-3-dependent cleavage during eisplatin-induced apoptosis in human ovarian epithelial cancer eells显示文摘 | Eric A Gordon B M Benjamin K T | 2001 | Cancer Res2001，61，5： | 1 |
| 13 | Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models显示文摘 | PATEL N V GORDON M N CONNOR K E | 2005 | Neurobiol Aging2005，26，： | 1 |
| 14 | Dimensinal stability and detail reproduction of irreversible hydrocolloid and elastomeric impressions disinfected by immersion显示文摘 | Johoson G H Chellis K D Gordon G E | 1998 | J Prosthet Dent1998，79，4： | 1 |
| 15 | Effects of advancing open face tunneling on an existing loaded pile显示文摘 | GORDON T K NG C W W | 2005 | Journal of Geotechnical and Geoenvironmental Engineering ASCE2005，131，2： | 1 |
| 16 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 17 | Using genetic algorithms for concept learning显示文摘 | DE JONG K A SPEARS W M GORDON F D | 1993 | Machine Learning1993，13，： | 1 |
| 18 | UVB light regulates expression ofantioxidants and inf]arl+rnatory mediators in human corneal epithelial cells显示文摘 | Black AT Gordon M K Heck DE el al | 2011 | Bioehem Pharmacol2011，81，： | 1 |
| 19 | Volatile organiccompounds in exhaled air from patients with lung cancer显示文摘 | Gordon S M Szidon J P Krotoszynski B K | 1985 | ClinChem1985，31，： | 1 |
| 20 | Literature-based discovery by lexical statistics 显示文摘 | LINDSAY R K GORDON M D | 1999 | Journal of American Society for Informa- tion Science1999，49，8： | 1 |
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