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| 1 | Randomized trial in malignant biliary obstruction:Plastic vs partially covered metal stents显示文摘AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent(pcSEMS)to plastic stent(PS)in patients treated for malignant,infrahilar biliary obstruction.METHODS:Multicenter prospective randomized clinical trial with treatment allocation to a pcWallstent(SEMS)or a 10 French PS.Palliative patients aged≥18,for infrahilar malignant biliary obstruction and a Karnofsky performance scale index>60%from 6 participating North American university centers.Primary endpoint was time to stent failure,with secondary outcomes of death,adverse events,Karnofsky performance score and short-form-36 scale administered on a three-monthly basis for up to 2 years.Survival analyses were performed for stent failure and death,with Cox proportional hazards regression models to determine significant predictive characteristics.RESULTS:Eighty-five patients were accrued over 37mo,42 were randomized to the SEMS group and 83patients were available for analyses.Time to stent failure was 385.3±52.5 d in the SEMS and 153.3±19.8 d in the PS group,P=0.006.Time to death did not differ between groups(192.3±23.4 d for SEMS vs211.5±28.0 d for PS,P=0.70).The only significant predictor was treatment allocation,relating to the time to stent failure(P=0.01).Amongst other measured outcomes,only cholangitis differed,being more common in the PS group(4.9%vs 24.5%,P=0.029).The small number of patients in follow-up limits longitudinal assessments of performance and quality of life.From an initially planned 120 patients,only 85 patients were recruited.CONCLUSION:Partially covered SEMS result in a longer duration till stent failure without increased complication rates,yet without accompanying measurable benefits in survival,performance,or quality of life. | Peter L Moses Khalid M AlNaamani Alan N Barkun Stuart R Gordon Roger D Mitty M Stanley Branch Thomas E Kowalski Myriam Martel Viviane Adam | 2013 | World Journal of Gastroenterology2013，19，46： | 6 |
| 2 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 3 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 4 | Literature-based discovery by lexical statistics 显示文摘 | LINDSAY R K GORDON M D | 1999 | Journal of American Society for Informa- tion Science1999，49，8： | 1 |
| 5 | A simple, moderately accurate, atmospheric correction algorithm for SeaWiFS显示文摘 | Wang M Gordon H R | 1994 | Remote Sensing of Environment1994，50，3： | 1 |
| 6 | Iron deficiency limits phytoplankton growth in Antarctic waters显示文摘 | Martin J H Fitzwater S E Gordon R M | | 0，，： | 1 |
| 7 | Iron in north-east Pacific waters显示文摘 | Gordon R M Martin J H Knauer G A | 1982 | Nature1982，299，： | 1 |
| 8 | Seasonal patterns of soil respiration and CO2 evolution following harvesting in the white spruce forests of interior Alaska显示文摘 | Gordon A M Schlentner R E Cleve K V | 1987 | Canadian Journal of Forest Research1987，17，4： | 1 |
| 9 | A Theory of Labor Market Segmentation显示文摘 | Gordon D Edwards R Reich M | | 0，，02： | 1 |
| 10 | Prolonged reduction of leukocyte membrane-associated dectin-1 levels following β-glucan administration显示文摘 | Ozment-Skelton T R Goldman M P Gordon S | 2006 | J Pharmacol Exp Ther2006，318，2： | 1 |
| 11 | Protocol for resolving protein mixtures in CZE显示文摘 | Gordon M J Lee K J Zare R N | 1991 | Anal Chem1991，63，： | 1 |
| 12 | Geographic iso- lation of Diplodia scrobiculata and its association with native Pinus radiata 显示文摘 | Burgess T I Gordon T R Wingfield M J | 2004 | Mycological Research2004，108，： | 1 |
| 13 | A study of the application of particle filters to single target tracking problem 显示文摘 | MORELANDE M R CHALLA S GORDON N | 2003 | Signal and Data Processing of Small Target2003，，5204： | 1 |
| 14 | Primary aldosteronism-careful investigation is essential and rewarding显示文摘 | Stowasser M Gordon R D | 2004 | Molecular and Cellular Endocrinology2004，217，12： | 1 |
| 15 | The case for iron显示文摘 | Martin J H Gordon R M Fitzwater S E | | 0，，： | 1 |
| 16 | Characterization of the phytochemicals and antioxidant properties of extracts from Teaw (Cratoxylum formosum Dyer)显示文摘 | Maisuthisakul P Pongsawatmanit R Gordon M H | 2007 | Food Chemistry2007，100，4： | 1 |
| 17 | Iron deficiency limits phytoplankton growth in Antarctic waters显示文摘 | MARTIN J H FITZWATER S E GORDON R M | 1990 | Global Biogeochemical Cycles1990，4，： | 1 |
| 18 | The Characterization of Technological Zinc Cycles显示文摘 | Gordon R B Graedel T E Bertram M | 2003 | Resources Conservation & Recycling2003，39，： | 1 |
| 19 | Persistent anomalies of the extratropieal northern hemisphere wintertime eireulation: Geographieal distribution and regional persistenee eharaeteristies 显示文摘 | Dole R M N D Gordon | 1983 | Mon Wea Rev1983，111，： | 1 |
| 20 | Drying and rewetting effects on soil microbial community composition and nutrient leaching显示文摘 | Gordon H Philip M H Bardgett R D | 2008 | Soil Biology & Biochemistry2008，40，： | 1 |
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